Patents by Inventor Alex Aronov

Alex Aronov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Indazolinone compositions useful as kinase inhibitors
    Patent number: 7262200
    Abstract: The present invention provides compounds of formula I: These compounds, and pharmaceutically acceptable compositions thereof, are useful generally as kinase inhibitors, particularly as inhibitors of PRAK, GSK3, ERK2, CDK2, MK2, SRC, SYK, and Aurora-2. Accordingly, compounds and compositions of the invention are useful for treating or lessening the severity of a variety of disorders, including, but not limited to, heart disease, diabetes, Alzheimer's disease, immunodeficiency disorders, inflammatory diseases, allergic diseases, autoimmune diseases, destructive bone disorders such as osteoporosis, proliferative disorders, infectious diseases and viral diseases.
    Type: Grant
    Filed: October 27, 2003
    Date of Patent: August 28, 2007
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Alex Aronov, David J. Lauffer, Huan Qui Li, Ronald Charles Tomlinson, Pan Li
  • Heterocyclic inhibitors of ERK2 and uses thereof
    Patent number: 7253187
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formula: wherein Z1 and Z2 are each independently nitrogen or CH and Ring A, TmR1, QR2, UnR3, and Sp are as described in the specification. The compounds are especially useful as inhibitors of ERK2 and for treating diseases in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, diabetes, and cardiovascular disease.
    Type: Grant
    Filed: February 3, 2004
    Date of Patent: August 7, 2007
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Jingrong Cao, Jeremy Green, Michael Hale, Francois Maltais, Judy Straub, Qing Tang, Alex Aronov
  • Heterocyclic protein kinase inhibitors and uses thereof
    Patent number: 7244735
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors of formula I: or a pharmaceutically acceptable salt thereof, wherein Ring B, Z1, Z2, U, p, Q, R1, R2, R3, and R3 are as defined herein. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including stroke, inflammatory disorders, autoimmune diseases such as SLE lupus and psoriasis, proliferative disorders such as cancer, and conditions associated with organ transplantation.
    Type: Grant
    Filed: December 2, 2004
    Date of Patent: July 17, 2007
    Assignee: Vertex Pharmaceuticals Inc.
    Inventors: Judith Straub, Michael Hale, Francois Maltais, Gabriel Martinez-Botella, Alex Aronov, Guy Bemis
  • Azaindoles useful as inhibitors of JAK and other protein kinases
    Publication number: 20070043063
    Abstract: The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: March 30, 2005
    Publication date: February 22, 2007
    Inventors: Francesco Salituro, Luc Farmer, Randy Bethiel, Edmund Harrington, Jeremy Green, John Court, Jon Come, David Lauffer, Alex Aronov, Hayley Binch, Dean Boyall, Jean-Damien Charrier, Simon Everitt, Damien Fraysse, Michael Mortimore, Francoise Pierard, Daniel Robinson, Jian Wang, Joanne Pinder, Tiansheng Wang
  • Imidazole compositions useful as inhibitors of protein kinases
    Patent number: 7169800
    Abstract: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides processes for preparing the compounds of this invention, pharmaceutically acceptable compositions comprising the compounds of the invention, and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: September 24, 2004
    Date of Patent: January 30, 2007
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Alex Aronov, David J. Lauffer, Pan Li, Ronald C. Tomlinson
  • Pyrrole compounds useful as kinase inhibitors
    Publication number: 20060173055
    Abstract: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds, processes for making the compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Application
    Filed: March 22, 2006
    Publication date: August 3, 2006
    Inventors: Alex Aronov, Upul Bandarage, David Lauffer, Pan Li, Ronald Tomlinson
  • Inhibitors of ERK protein kinase and uses thereof
    Publication number: 20060142572
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors of formula I: or a pharmaceutically acceptable salt thereof, wherein Ring A, Z1, Z2, U, Q, R1, R2, and L are as defined herein. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including proliferative disorders such as cancer.
    Type: Application
    Filed: December 13, 2005
    Publication date: June 29, 2006
    Inventors: Gabriel Martinez-Botella, Alex Aronov, Michael Hale, Francois Maltais, Judith Straub, Qing Tang
  • Pyrazolo[1,5-a]pyrimidines useful as inhibitors of protein kinases
    Publication number: 20060135537
    Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing the compounds of the invention.
    Type: Application
    Filed: November 4, 2005
    Publication date: June 22, 2006
    Inventors: Ronald Knegtel, Juan-Miguel Jimenez, Jean-Damien Charrier, Dean Stamos, Pan Li, Jon Come, Alex Aronov
  • Heterocyclic protein kinase inhibitors and uses thereof
    Publication number: 20050245499
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors of formula I: or a pharmaceutically acceptable salt thereof, wherein Ring B, Z1, Z2, U, p, Q, R1, R2, R3, and R3 are as defined herein. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including stroke, inflammatory disorders, autoimmune diseases such as SLE lupus and psoriasis, proliferative disorders such as cancer, and conditions associated with organ transplantation.
    Type: Application
    Filed: December 2, 2004
    Publication date: November 3, 2005
    Inventors: Judith Straub, Michael Hale, Francois Maltais, Gabriel Martinez-Botella, Alex Aronov, Guy Bemis
  • Imidazole compositions useful as inhibitors of protein kinases
    Publication number: 20050148574
    Abstract: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides processes for preparing the compounds of this invention, pharmaceutically acceptable compositions comprising the compounds of the invention, and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: September 24, 2004
    Publication date: July 7, 2005
    Inventors: Alex Aronov, David Lauffer, Pan Li, Ronald Tomlinson
  • Compositions useful as inhibitors of protein kinases
    Publication number: 20050137201
    Abstract: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Application
    Filed: September 7, 2004
    Publication date: June 23, 2005
    Inventors: Alex Aronov, David Lauffer, Pan Li, Ronald Tomlinson
  • Pyrrole compositions useful as inhibitors of c-Met
    Publication number: 20050101650
    Abstract: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds, processes for making the compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Application
    Filed: August 16, 2004
    Publication date: May 12, 2005
    Inventors: Alex Aronov, Upul Bandarage, David Lauffer, Pan Li, Ronald Tomlinson
  • Heterocyclic inhibitors of ERK2 and uses thereof
    Publication number: 20040229875
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formula: 1
    Type: Application
    Filed: February 3, 2004
    Publication date: November 18, 2004
    Inventors: Jingrong Cao, Jeremy Green, Michael Hale, Francois Maltais, Judy Straub, Qing Tang, Alex Aronov
  • Compositions useful as protein kinase inhibitors
    Publication number: 20040220200
    Abstract: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Application
    Filed: March 11, 2004
    Publication date: November 4, 2004
    Inventors: Francois Maltais, Alex Aronov, Michael R. Hale, Young-Choon Moon
  • Heteroaryl compounds useful as inhibitors of protein kinases
    Publication number: 20040214928
    Abstract: The present invention provides compounds that are inhibitors of protein kinase, particularly inhibitors of ERK2, GSK3, PKA, CDK2 protein kinases, mammalian protein kinases involved in proliferative and neurodegenerative disorders. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of utilizing those compositions in the treatment of various disorders.
    Type: Application
    Filed: February 3, 2004
    Publication date: October 28, 2004
    Inventors: Alex Aronov, Michael R. Hale, Francois Maltais, Qing Tang
  • Compositions useful as inhibitors of protein kinases
    Publication number: 20040198750
    Abstract: The present invention relates to compounds useful as inhibitors of protein kinasas. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Application
    Filed: March 25, 2004
    Publication date: October 7, 2004
    Inventors: Jeremy Green, Alex Aronov, Albert C. Pierce
  • Indazolinone compositions useful as kinase inhibitors
    Publication number: 20040167121
    Abstract: The present invention provides compounds of formula I: 1
    Type: Application
    Filed: October 27, 2003
    Publication date: August 26, 2004
    Inventors: Alex Aronov, David J. Lauffer, Huan Qui Li, Ronald Charles Tomlinson, Pan Li
  • Heterocyclic inhibitors of ERK2 and uses thereof
    Patent number: 6743791
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formula: wherein Z1 and Z2 are each independently nitrogen or CH and Ring A, TmR1, QR2, UnR3, and Sp are as described in the specification. The compounds are especially useful as inhibitors of ERK2 and for treating diseases in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, diabetes, and cardiovascular disease.
    Type: Grant
    Filed: February 8, 2002
    Date of Patent: June 1, 2004
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Jingrong Cao, Jeremy Green, Michael Hale, Francois Maltais, Judy Straub, Qing Tang, Alex Aronov
  • Heterocyclic inhibitors of ERK2 and uses thereof
    Publication number: 20030092714
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formula: 1
    Type: Application
    Filed: February 8, 2002
    Publication date: May 15, 2003
    Inventors: Jingrong Cao, Jeremy Green, Michael Hale, Francois Maltais, Judy Straub, Qing Tang, Alex Aronov