Patents by Inventor Alex B. Callahan

Alex B. Callahan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8906110
    Abstract: The invention is directed toward a cartilage repair assembly comprising a shaped allograft two piece construct with a demineralized cancellous cap and a mineralized cylindrical base member defining a blind bore with a through-going transverse bore intersecting the blind bore. The demineralized cancellous cap has a cylindrical top portion and a smaller diameter cylindrical stem extending away from the top portion which fits into the blind bore of the mineralized base member. The cap stem defines a transverse through-going bore which is aligned with the through-going bore of the base member to receive a cylindrical cortical pin holding the cap within the base member. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that the assembly engages the side wall of the drilled bore in an interference fit.
    Type: Grant
    Filed: September 14, 2010
    Date of Patent: December 9, 2014
    Assignee: Musculoskeletal Transplant Foundation
    Inventors: Eric J. Semler, Katherine G. Truncale, Alex B. Callahan, Judith I. Yannariello-Brown
  • Patent number: 8435551
    Abstract: The invention is directed toward an osteochondral repair assembly comprising a shaped allograft construct comprising an unbalanced barbell-shaped cylindrical cancellous bone primary member formed with a mineralized cylindrical base section having a smaller diameter cylindrical stem leading to a second cylindrical section which is demineralized. A mineralized ring-shaped support member is forced over the compressed demineralized second demineralized the aperture of the ring-shaped member to fit around the stem with one ring surface being adjacent the bottom surface to the second cylindrical section and the opposite ring surface being adjacent the upper surface of the mineralized cylindrical base section.
    Type: Grant
    Filed: July 24, 2009
    Date of Patent: May 7, 2013
    Assignee: Musculoskeletal Transplant Foundation
    Inventors: Eric J. Semler, Roman Shikhanovich, Alex B. Callahan, Katherine Gomes Truncale, Judith I. Yannariello-Brown, Yen-Chen Huang
  • Publication number: 20110224797
    Abstract: The invention is directed toward a cartilage repair assembly comprising a shaped allograft two piece construct with a demineralized cancellous cap and a mineralized cylindrical base member defining a blind bore with a through-going transverse bore intersecting the blind bore. The demineralized cancellous cap has a cylindrical top portion and a smaller diameter cylindrical stem extending away from the top portion which fits into the blind bore of the mineralized base member. The cap stem defines a transverse through-going bore which is aligned with the through-going bore of the base member to receive a cylindrical cortical pin holding the cap within the base member. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that the assembly engages the side wall of the drilled bore in an interference fit.
    Type: Application
    Filed: September 14, 2010
    Publication date: September 15, 2011
    Inventors: Eric J. Semler, Katherine G. Truncale, Alex B. Callahan, Judith I. Yannariello-Brown
  • Patent number: 7837740
    Abstract: The invention is directed toward a cartilage repair assembly comprising a shaped allograft two piece construct with a demineralized cancellous cap and a mineralized cylindrical base member defining a blind bore with a through going transverse bore intersecting the blind bore. The demineralized cancellous cap has a cylindrical top portion and a smaller diameter cylindrical stem extending away from the top portion which fits into the blind bore of the mineralized base member. The cap stem defines a transverse through going bore which is aligned with the through going bore of the base member to receive a cylindrical cortical pin holding the cap within the base member. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that the assembly engages the side wall of the drilled bore in an interference fit.
    Type: Grant
    Filed: January 24, 2007
    Date of Patent: November 23, 2010
    Assignee: Musculoskeletal Transplant Foundation
    Inventors: Eric J. Semler, Katherine G. Truncale, Alex B. Callahan, Judith I. Yannariello-Brown
  • Publication number: 20100274362
    Abstract: Mixtures, such as gels or pastes, comprising freeze-milled cartilage particles and exogenous growth factors are used for repairing chondral defects. Such mixtures may be applied to constructs comprising cancellous bone for implantation at the defect site. Suitable growth factors include variants of FGF-2, particularly variants that include a sole amino acid substitution for asparagine at amino acid 111 of the ?8-?9 loop of the FGF-2 peptide. Such FGF-2 variants are released slowly and continuously at a constant rate from cartilage pastes. In other embodiments, the amino acid substituted for asparigine is glycine. Other variants that may be used include FGF-9 variants having truncated chains and a sole amino acid substitution in the ?8-?9 loop of the FGF-9 peptide either for tryptophan at amino acid 144 or for asparagine at amino acid 143.
    Type: Application
    Filed: January 14, 2010
    Publication date: October 28, 2010
    Inventors: Avner Yayon, Katherine G. Truncale, Hilla Barkay-Olami, Alex B. Callahan, Arthur A. Gertzman, Yen-Chen Huang, Morris L. Jacobs, John C. Munson, Eric J. Semler, Roman Shikhanovich, Baruch Stern, Moon Hae Sunwoo, William W. Tomford, Judith I. Yannariello-Brown
  • Publication number: 20100015202
    Abstract: The invention is directed toward an osteochondral repair assembly comprising a shaped allograft construct comprising an unbalanced barbell-shaped cylindrical cancellous bone primary member formed with a mineralized cylindrical base section having a smaller diameter cylindrical stem leading to a second cylindrical section which is demineralized. A mineralized ring-shaped support member is forced over the compressed demineralized second demineralized the aperture of the ring-shaped member to fit around the stem with one ring surface being adjacent the bottom surface to the second cylindrical section and the opposite ring surface being adjacent the upper surface of the mineralized cylindrical base section.
    Type: Application
    Filed: July 24, 2009
    Publication date: January 21, 2010
    Inventors: Eric J. Semler, Roman Shikhanovich, Alex B. Callahan, Katherine Gomes Truncale, Judith I. Yannariello-Brown, Yen-Chen Huang
  • Publication number: 20090319045
    Abstract: Constructs that are at least partially constructed of allograft cancellous bone are disclosed, along with cartilage particles that may be used with the constructs for repairing articular cartilage defects. A multi-piece construct includes a base member, a cap member and at least one pin that secures the cap member to the base member. The base member may be constructed of mineralized cancellous bone, and is used to replace the subchondral bone removed when a surgeon cuts a bore in the area of an adjacent cartilage defect. The base member includes a blind bore and first and second through-going transverse bores in opposite sides of a wall of the base member. The cap member includes an upper section that has a thickness that is similar to that of a patient's surrounding articular cartilage layer and a stem depending from the upper section that is dimensioned to be received in and by the blind bore of the base member.
    Type: Application
    Filed: March 5, 2009
    Publication date: December 24, 2009
    Inventors: Katherine G. Truncale, Eric J. Semler, Arthur A. Gertzman, Moon Hae Sunwoo, William W. Tomford, Roman Shikhanovich, Alex B. Callahan, Judith I. Yannariello-Brown, Morris L. Jacobs, John C. Munson, Yen-Chen Huang
  • Publication number: 20090149893
    Abstract: The invention is directed toward a cartilage repair assembly comprising a shaped allograft construct comprising a cylindrical mineralized cancellous bone base member and a demineralized cancellous bone cap member having a cylindrical top portion and a stem extending from the top portion mounted to the bone base member. The base member has a central bore and a transverse bore which intersect the central bore and the cap member stem has a through going bore which is aligned with the base member transverse bore when the stem is mounted in the central bore to receive a pin member. Milled cartilage particles having a size ranging from 10 to 212 microns are mixed with a biocompatible carrier and a cartilage growth factor, with the mixture being infused in the cap member to generate cartilage growth.
    Type: Application
    Filed: December 4, 2008
    Publication date: June 11, 2009
    Inventors: Eric J. Semler, Alex B. Callahan, Katherine G. Truncale, Roman Shikhanovich
  • Publication number: 20080255676
    Abstract: The invention is directed toward a cartilage repair assembly comprising a shaped allograft two piece construct with a demineralized cancellous cap and a mineralized cylindrical base member defining a blind bore with a through going transverse bore intersecting the blind bore. The demineralized cancellous cap has a cylindrical top portion and a smaller diameter cylindrical stem extending away from the top portion which fits into the blind bore of the mineralized base member. The cap stem defines a transverse through going bore which is aligned with the through going bore of the base member to receive a cylindrical cortical pin holding the cap within the base member. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that the assembly engages the side wall of the drilled bore in an interference fit.
    Type: Application
    Filed: January 24, 2007
    Publication date: October 16, 2008
    Inventors: Eric J. Semler, Katherine G. Truncale, Alex B. Callahan, Judith I. Yannariello-Brown
  • Publication number: 20080220044
    Abstract: The invention is directed toward an osteochondral repair assembly comprising a shaped allograft construct comprising an unbalanced barbell-shaped cylindrical cancellous bone primary member formed with a mineralized cylindrical base section having a smaller diameter cylindrical stem leading to a second cylindrical section which is demineralized. A mineralized ring-shaped support member is forced over the compressed demineralized second demineralized the aperture of the ring-shaped member to fit around the stem with one ring surface being adjacent the bottom surface to the second cylindrical section and the opposite ring surface being adjacent the upper surface of the mineralized cylindrical base section.
    Type: Application
    Filed: March 5, 2008
    Publication date: September 11, 2008
    Inventors: Eric J. Semler, Roman Shikhanovich, Alex B. Callahan, Katherine G. Truncale, Judith I. Yannariello-Brown