Abstract: A video streaming service may include a segmentation component that provides segment metadata that indicates starting locations for a plurality of segments of video content that are produced during transcoding of the video content. The segment metadata may be sent to a first transcode server and a second transcode server to allow alignment of segmentations between the first transcode server and the second transcode server. This may allow transcoding of the video content to be seamlessly switched from the first transcode server to the second transcode server, during transmission of the video content, without causing interruption of playback. The first transcode server and the second transcode server may also operate in parallel to produce different versions of the video content, such as versions encoded using different codecs. A video player may seamlessly switch between these different codec versions without causing interruption of playback.

Abstract: A dual chamber applicator includes an elongated tube having a sealed end and an open end, a first ampoule disposed in the elongated tube and containing a first composition including a pharmaceutically active agent and optionally a first volatile solvent, water, or a combination thereof, a second ampoule disposed in the elongated tube and containing a second composition including a resin based tincture, a second volatile solvent and water, and an applicator device provided at the open end of the elongated tube. The first composition is configured to combine with the second composition within the elongated tube to form a medicine to be delivered to a mucosal site or a skin site. The applicator device is configured to control flow of the medicine out of the open end of the elongated tube and deliver the medicine via topical, transdermal or transmucosal delivery.

Abstract: Described are pharmacological compositions comprising a gum resin; a pharmacologically active agent and a topically acceptable volatile solvent for the gum resin and active agent. Also described are methods for the transdermal or transmucosal delivery of a pharmacologically active agent using such compositions.

Abstract: The invention provides a biological dressing for treatment of a condition of the skin, mucosa, teeth or other tissue within or proximate to the oral cavity of a subject, the biological dressing comprised of a gum resin, a topically acceptable volatile solvent, and an oral care agent. The gum resin is present in a suitable amount that the composition, when the solvent evaporates, will dry to form a solid coating that sticks to the tissue to which the composition is applied and maintain the oral care agent over a sustained period of time in contact with sites on the tissue exhibiting symptoms of the condition. Methods are provided for treating symptoms of oral condition with such a oral care composition.

Abstract: A dual chamber applicator includes an elongated tube having a sealed end and an open end, a first ampoule disposed in the elongated tube and containing a first composition including a pharmaceutically active agent and optionally a first volatile solvent, water, or a combination thereof, a second ampoule disposed in the elongated tube and containing a second composition including a resin based tincture, a second volatile solvent and water, and an applicator device provided at the open end of the elongated tube. The first composition is configured to combine with the second composition within the elongated tube to form a medicine to be delivered to a mucosal site or a skin site. The applicator device is configured to control flow of the medicine out of the open end of the elongated tube and deliver the medicine via topical, transdermal or transmucosal delivery.

Abstract: Described herein are methods for making a pharmaceutical composition for topical, transdermal or transmucosal delivery of a pharmaceutically active agent comprising combining (i) a first composition comprising or consisting of a pharmaceutically active agent and, optionally, a first volatile solvent and/or water, and (ii) a second composition comprising a resin, a second volatile solvent and 10-40% v/v water. Compositions made by these methods also are described, as are compositions comprising a pharmaceutically active agent, a volatile solvent, a resin and 10-40% (w/v) water, and containers containing such compositions or components thereof.

Abstract: Described are pharmacological compositions comprising a gum resin; a pharmacologically active agent and a topically acceptable volatile solvent for the gum resin and active agent. Also described are methods for the transdermal or transmucosal delivery of a pharmacologically active agent using such compositions.

Abstract: A method of rapid transbuccal delivery of an active agent into the bloodstream is provided. The method can include providing a pharmaceutical composition comprising the active agent, resin and a volatile solvent and, optionally, water. In some embodiments, the method achieves a Tmax 60 minutes or less, an onset of therapeutic effect of 60 minutes or less, and/or achieves therapeutic serum levels of the active agent within 60 minutes or less. Related compositions also are provided.

Abstract: Described are pharmacological compositions comprising a gum resin; a pharmacologically active agent and a topically acceptable volatile solvent for the gum resin and active agent. Also described are methods for the transdermal or transmucosal delivery of a pharmacologically active agent using such compositions.

Abstract: The invention provides a biological dressing for treatment of a dermatological disease comprised of one or more resins or other film-forming agents, a topically acceptable volatile solvent, and a pharmacologically active agent. The combined one or more resins are present in a suitable amount such that the composition, when the solvent evaporates, will dry to form a solid coating that sticks to the skin, nail or mucosal membrane to which the composition is applied, and maintain the pharmacologically active agent over a sustained period of time in contact with sites on the skin or mucosal membranes exhibiting symptoms of the disease. Methods are provided for treating symptoms of dermatological diseases with such a pharmacological composition.

Abstract: The invention provides a biological dressing for treatment of a dermatological disease comprised of a gum resin, a topically acceptable volatile solvent, and a pharmacologically active agent. The gum resin is present in a suitable amount that the composition, when the solvent evaporates, will dry to form a solid coating that sticks to the skin or mucosal membrane to which the composition is applied and maintain the pharmacologically active agent over a sustained period of time in contact with sites on the skin or mucosal membranes exhibiting symptoms of the disease. Methods are provided for treating symptoms of dermatological diseases with such a pharmacological composition. Biological dressings including tincture of benzoin and clotrimazole are shown to be efficacious for the long-term amelioration of symptoms of athlete's foot.

Abstract: Described are pharmacological compositions comprising a gum resin; a pharmacologically active agent and a topically acceptable volatile solvent for the gum resin and active agent. Also described are methods for the transdermal or transmucosal delivery of a pharmacologically active agent using such compositions.

Abstract: A solar electric generator is disclosed that includes a sealed cylindrical casing having a depression in the cylindrical wall, the casing being made of a material that allows the energy of sunlight therethrough, a magnetic wire coiled in the depression, a strut positioned within the casing along a center axis, and a plurality of magnetized vanes configured to rotate (with low friction) on the strut proximate the depression, the vanes having a black side and a white side, an outer portion of the vane being shaped to correspond to the depression in the casing. Other embodiments and methods of generating an alternating current are also disclosed.

Abstract: The invention provides a biological dressing for treatment of a dermatological disease comprised of one or more resins or other film-forming agents, a topically acceptable volatile solvent, and a pharmacologically active agent. The combined one or more resins are present in a suitable amount such that the composition, when the solvent evaporates, will dry to form a solid coating that sticks to the skin, nail or mucosal membrane to which the composition is applied, and maintain the pharmacologically active agent over a sustained period of time in contact with sites on the skin or mucosal membranes exhibiting symptoms of the disease. Methods are provided for treating symptoms of dermatological diseases with such a pharmacological composition.

Abstract: The invention provides a biological dressing for treatment of a dermatological disease comprised of one or more resins or other film-forming agents, a topically acceptable volatile solvent, and a pharmacologically active agent. The combined one or more resins are present in a suitable amount such that the composition, when the solvent evaporates, will dry to form a solid coating that sticks to the skin, nail or mucosal membrane to which the composition is applied, and maintain the pharmacologically active agent over a sustained period of time in contact with sites on the skin or mucosal membranes exhibiting symptoms of the disease. Methods are provided for treating symptoms of dermatological diseases with such a pharmacological composition.

Abstract: The invention provides a biological dressing for treatment of a dermatological disease comprised of a gum resin, a topically acceptable volatile solvent, and a pharmacologically active agent. The gum resin is present in a suitable amount that the composition, when the solvent evaporates, will dry to form a solid coating that sticks to the skin or mucosal membrane to which the composition is applied and maintain the pharmacologically active agent over a sustained period of time in contact with sites on the skin or mucosal membranes exhibiting symptoms of the disease. Methods are provided for treating symptoms of dermatological diseases with such a pharmacological composition. Biological dressings including tincture of benzoin and clotrimazole are shown to be efficacious for the long-term amelioration of symptoms of athlete's foot.

Abstract: The invention provides a biological dressing for treatment of a condition of the skin, mucosa, teeth or other tissue within or proximate to the oral cavity of a subject, the biological dressing comprised of a gum resin, a topically acceptable volatile solvent, and an oral care agent. The gum resin is present in a suitable amount that the composition, when the solvent evaporates, will dry to form a solid coating that sticks to the tissue to which the composition is applied and maintain the oral care agent over a sustained period of time in contact with sites on the tissue exhibiting symptoms of the condition. Methods are provided for treating symptoms of oral condition with such a oral care composition.

Abstract: The invention provides a biological dressing for treatment of a dermatological disease comprised of a gum resin, a topically acceptable volatile solvent, and a pharmacologically active agent. The gum resin is present in a suitable amount that the composition, when the solvent evaporates, will dry to form a solid coating that sticks to the skin or mucosal membrane to which the composition is applied and maintain the pharmacologically active agent over a sustained period of time in contact with sites on the skin or mucosal membranes exhibiting symptoms of the disease. Methods are provided for treating symptoms of dermatological diseases with such a pharmacological composition. Biological dressings including tincture of benzoin and clotrimazole are shown to be efficacious for the long-term amelioration of symptoms of athlete's foot.

Abstract: The invention provides a biological dressing for treatment of a dermatological disease comprised of a gum resin, a topically acceptable volatile solvent, and a pharmacologically active agent. The gum resin is present in a suitable amount that the composition, when the solvent evaporates, will dry to form a solid coating that sticks to the skin or mucosal membrane to which the composition is applied and maintain the pharmacologically active agent over a sustained period of time in contact with sites on the skin or mucosal membranes exhibiting symptoms of the disease. Methods are provided for treating symptoms of dermatological diseases with such a pharmacological composition. Biological dressings including tincture of benzoin and clotrimazole are shown to be efficacious for the long-term amelioration of symptoms of athlete's foot.