Abstract: A device and method for fluorescent imaging may include an imaging unit including a fluorescent camera with an optical detector that is configured to acquire a fluorescent image of a fluorescing sample, the image including raw pixel values. A user interface may display an image formed from display image pixels derived from the raw image pixels. A distance sensor may measure a distance to the fluorescing sample. A distance between the optical detector and fluorescing sample may be determined from the measured distance. A processing unit may obtain a gain value, match the determined distance to a distance value associated a respective gain range, and impose limits of the gain values range onto the gain value, to determine a limited gain value. The limited gain value may be applied to the raw image pixels, thereby deriving display image pixels.

Abstract: A novel dual-path-endoscope where a multi-function light source produces a first-light and a second-light toward an object. The first-light exhibits first-light-characteristics. The second-light exhibits second-light-characteristics different from the first-light-characteristics. The endoscope includes two light-paths, the disparity there between is larger than zero. Each light-path includes a respective pupil and a respective light-separator coupled with the pupil, transmitting there through one of the first-light and the second-light, associating the first-light and the second-light with a respective light-path. The dual-channel-imager includes two imager sensors, each associated with a respective light-path and optically coupled with a respective light-separator. Each imaging-sensor exhibits sensitivity to the characteristics of the respective one of the first-light and the second-light.

Abstract: A novel dual-path-endoscope where a multi-function light source produces a first-light and a second-light toward an object. The first-light exhibits first-light-characteristics. The second-light exhibits second-light-characteristics different from the first-light-characteristics. The endoscope includes two light-paths, the disparity there between is larger than zero. Each light-path includes a respective pupil and a respective light-separator coupled with the pupil, transmitting there through one of the first-light and the second-light, associating the first-light and the second-light with a respective light-path. The dual-channel-imager includes two imager sensors, each associated with a respective light-path and optically coupled with a respective light-separator. Each imaging-sensor exhibits sensitivity to the characteristics of the respective one of the first-light and the second-light.

Abstract: A novel dual-path-endoscope where a multi-function light source produces a first-light and a second-light toward an object. The first-light exhibits first-light-characteristics. The second-light exhibits second-light-characteristics different from the first-light-characteristics. The endoscope includes two light-paths, the disparity there between is larger than zero. Each light-path includes a respective pupil and a respective light-separator coupled with the pupil, transmitting there through one of the first-light and the second-light, associating the first-light and the second-light with a respective light-path. The dual-channel-imager includes two imaging sensors, each associated with a respective light-path and optically coupled with a respective light-separator. Each imaging-sensor exhibits sensitivity to the characteristics of the respective one of the first-light and the second-light.

Abstract: A device and method for fluorescent imaging may include an imaging unit including a fluorescent camera with an optical detector that is configured to acquire a fluorescent image of a fluorescing sample, the image including raw pixel values. A user interface may display an image formed from display image pixels derived from the raw image pixels. A distance sensor may measure a distance to the fluorescing sample. A distance between the optical detector and fluorescing sample may be determined from the measured distance. A processing unit may obtain a gain value, match the determined distance to a distance value associated a respective gain range, and impose limits of the gain values range onto the gain value, to determine a limited gain value. The limited gain value may be applied to the raw image pixels, thereby deriving display image pixels.

Abstract: A fluorescence imaging system including a light source, an optical system, camera and an excitation light filter, the optical system produces a non-uniform fluence excitation illumination beam for illuminating an object and promoting fluorescence emissions, the optical system is positioned between the light source and the object, the optical system modifies the non-uniform fluence illumination beam into a uniform fluence illumination beam and changes the divergence of the uniform fluence illumination beam, the camera has an array of pixels, the camera detects the fluorescence emissions and performs pixel intensity measurements for each of the pixels, the excitation light filter is positioned between the object and the camera and filters out the excitation illumination beam, such that the excitation illumination beam does not reach the camera.

Abstract: Fluorescence imaging illumination fiber including a first fiber, a second fiber, and a diffuser, the second fiber concentrically enfolding the first fiber, the diffuser is coupled at the end of the first fiber and the second fiber, the first fiber having a first angular output, the second fiber having a second angular output, the diffuser increasing the first angular output by a first value and increasing the second angular output by a second value, the first value exceeding the second value.

Abstract: A novel dual-path-endoscope where a multi-function light source produces a first-light and a second-light toward an object. The first-light exhibits first-light-characteristics. The second-light exhibits second-light-characteristics different from the first-light-characteristics. The endoscope includes two light-paths, the disparity there between is larger than zero. Each light-path includes a respective pupil and a respective light-separator coupled with the pupil, transmitting there through one of the first-light and the second-light, associating the first-light and the second-light with a respective light-path. The dual-channel-imager includes two imaging sensors, each associated with a respective light-path and optically coupled with a respective light-separator. Each imaging-sensor exhibits sensitivity to the characteristics of the respective one of the first-light and the second-light.

Abstract: A fluorescence imaging system including a light source, an optical system, camera and an excitation light filter, the optical system produces a non-uniform fluence excitation illumination beam for illuminating an object and promoting fluorescence emissions, the optical system is positioned between the light source and the object, the optical system modifies the non-uniform fluence illumination beam into a uniform fluence illumination beam and changes the divergence of the uniform fluence illumination beam, the camera has an array of pixels, the camera detects the fluorescence emissions and performs pixel intensity measurements for each of the pixels, the excitation light filter is positioned between the object and the camera and filters out the excitation illumination beam, such that the excitation illumination beam does not reach the camera.

Abstract: Fluorescence imaging illumination fiber including a first fiber, a second fiber, and a diffuser, the second fiber concentrically enfolding the first fiber, the diffuser is coupled at the end of the first fiber and the second fiber, the first fiber having a first angular output, the second fiber having a second angular output, the diffuser increasing the first angular output by a first value and increasing the second angular output by a second value, the first value exceeding the second value.