Patents by Inventor Alex Cherkasskiy
Alex Cherkasskiy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8697450Abstract: Described herein are methods for determining an amount of an analyte in a test sample. The methods involve preparing a calibration curve using standard samples containing an isotopically-labeled standard in a biological matrix.Type: GrantFiled: March 5, 2013Date of Patent: April 15, 2014Assignee: PerkinElmer Health Sciences, Inc.Inventors: Blas Cerda, Alex Cherkasskiy
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Publication number: 20130244269Abstract: Described herein are methods for determining an amount of an analyte in a test sample. The methods involve preparing a calibration curve using standard samples containing an isotopically-labeled standard in a biological matrix.Type: ApplicationFiled: March 5, 2013Publication date: September 19, 2013Applicant: PERKINELMER HEALTH SCIENCES, INC.Inventors: Blas Cerda, Alex Cherkasskiy
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Patent number: 8513025Abstract: This invention relates, inter alia, to detecting and/or measuring succinylacetone and one or more additional biological analytes using mass spectrometry, e.g., tandem mass spectrometry, by derivatizing succinylacetone in a sample by contacting the sample with an extraction solution comprising a C1-3 linear or branched chain monoalcohol and a strong base selected from the group consisting of hydrazine, a modified hydrazine, and hydroxylamine.Type: GrantFiled: August 9, 2012Date of Patent: August 20, 2013Assignee: PerkinElmer Health Sciences, Inc.Inventors: Blas Cerda, Alex Cherkasskiy, Yijun Li
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Patent number: 8415162Abstract: Described herein are methods for determining an amount of an analyte in a test sample. The methods involve preparing a calibration curve using standard samples containing an isotopically-labeled standard in a biological matrix.Type: GrantFiled: August 3, 2012Date of Patent: April 9, 2013Assignee: PerkinElmer Health Sciences, Inc.Inventors: Blas Cerda, Alex Cherkasskiy
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Publication number: 20120309096Abstract: This invention relates, inter alia, to detecting and/or measuring succinylacetone and one or more additional biological analytes using mass spectrometry.Type: ApplicationFiled: August 9, 2012Publication date: December 6, 2012Applicant: PerkinElmer Health Sciences, Inc.Inventors: Blas Cerda, Alex Cherkasskiy, Yijun Li
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Publication number: 20120295361Abstract: Described herein are methods for determining an amount of an analyte in a test sample. The methods involve preparing a calibration curve using standard samples containing an isotopically-labeled standard in a biological matrix.Type: ApplicationFiled: August 3, 2012Publication date: November 22, 2012Inventors: Blas Cerda, Alex Cherkasskiy
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Publication number: 20120295295Abstract: Methods of evaluating molecular isomers of branched-chain amino acids are featured. The methods can include: derivatizing one or more molecular isomers of branched-chain amino acids in a sample comprising a branched-chain amino acid labeled with one or more heavy atoms as a first standard; adding, to the sample, after derivatization, a nonderivatized or derivatized branched chain amino acid that is labeled with one or more heavy atoms, as a second standard; evaluating the sample using tandem mass spectrometry; and detecting peaks indicative of derivatized and nonderivatized forms of one or more branched-chain amino acids in the sample.Type: ApplicationFiled: July 16, 2012Publication date: November 22, 2012Applicant: PERKINELMER LAS, INC.Inventors: Blas Cerda, Alex Cherkasskiy, Yijun Li
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Patent number: 8278116Abstract: This invention relates, inter alia, to detecting and/or measuring succinylacetone and one or more additional biological analytes using mass spectrometry.Type: GrantFiled: April 22, 2011Date of Patent: October 2, 2012Assignee: PerkinElmer Health Sciences, Inc.Inventors: Blas Cerda, Alex Cherkasskiy, Yijun Li
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Patent number: 8257977Abstract: Described herein are methods for determining an amount of an analyte in a test sample. The methods involve preparing a calibration curve using standard samples containing an isotopically-labeled standard in a biological matrix.Type: GrantFiled: July 26, 2010Date of Patent: September 4, 2012Assignee: PerkinElmer Health Sciences, Inc.Inventors: Blas Cerda, Alex Cherkasskiy
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Patent number: 8247236Abstract: Methods of evaluating molecular isomers of branched-chain amino acids are featured. The methods can include: derivatizing one or more molecular isomers of branched-chain amino acids in a sample comprising a branched-chain amino acid labeled with one or more heavy atoms as a first standard; adding, to the sample, after derivatization, a nonderivatized or derivatized branched chain amino acid that is labeled with one or more heavy atoms, as a second standard; evaluating the sample using tandem mass spectrometry; and detecting peaks indicative of derivatized and nonderivatized forms of one or more branched-chain amino acids in the sample.Type: GrantFiled: April 11, 2011Date of Patent: August 21, 2012Assignee: PerkinElmer Health Sciences, Inc.Inventors: Blas Cerda, Alex Cherkasskiy, Yijun Li
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Publication number: 20110201539Abstract: This invention relates, inter alia, to detecting and/or measuring succinylacetone and one or more additional biological analytes using mass spectrometry.Type: ApplicationFiled: April 22, 2011Publication date: August 18, 2011Applicant: PERKINELMER HEALTH SCIENCES, INC.Inventors: Blas Cerda, Alex Cherkasskiy, Yijun Li
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Publication number: 20110189780Abstract: Methods of evaluating molecular isomers of branched-chain amino acids are featured. The methods can include: derivatizing one or more molecular isomers of branched-chain amino acids in a sample comprising a branched-chain amino acid labeled with one or more heavy atoms as a first standard; adding, to the sample, after derivatization, a nonderivatized or derivatized branched chain amino acid that is labeled with one or more heavy atoms, as a second standard; evaluating the sample using tandem mass spectrometry; and detecting peaks indicative of derivatized and nonderivatized forms of one or more branched-chain amino acids in the sample.Type: ApplicationFiled: April 11, 2011Publication date: August 4, 2011Applicant: PERKINELMER HEALTH SCIENCES, INC.Inventors: Blas Cerda, Alex Cherkasskiy, Yijun Li
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Patent number: 7951608Abstract: This invention relates, inter alia, to detecting and/or measuring succinylacetone and one or more additional biological analytes using mass spectrometry.Type: GrantFiled: May 4, 2007Date of Patent: May 31, 2011Assignee: PerkinElmer Health Sciences, Inc.Inventors: Blas Cerda, Alex Cherkasskiy, Yijun Li
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Patent number: 7923257Abstract: Methods of evaluating molecular isomers of branched-chain amino acids are featured. The methods can include: derivatizing one or more molecular isomers of branched-chain amino acids in a sample comprising a branched-chain amino acid labeled with one or more heavy atoms as a first standard; adding, to the sample, after derivatization, a nonderivatized or derivatized branched chain amino acid that is labeled with one or more heavy atoms, as a second standard; evaluating the sample using tandem mass spectrometry; and detecting peaks indicative of derivatized and nonderivatized forms of one or more branched-chain amino acids in the sample.Type: GrantFiled: May 4, 2007Date of Patent: April 12, 2011Assignee: PerkinElmer Health Sciences, Inc.Inventors: Blas Cerda, Alex Cherkasskiy, Yijun Li
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Publication number: 20110020942Abstract: Described herein are methods for determining an amount of an analyte in a test sample. The methods involve preparing a calibration curve using standard samples containing an isotopically-labeled standard in a biological matrix.Type: ApplicationFiled: July 26, 2010Publication date: January 27, 2011Inventors: Blas Cerda, Alex Cherkasskiy
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Publication number: 20080274563Abstract: This invention relates, inter alia, to detecting and/or measuring succinylacetone and one or more additional biological analytes using mass spectrometry.Type: ApplicationFiled: May 4, 2007Publication date: November 6, 2008Applicant: PerkinElmer LAS, Inc.Inventors: Blas Cerda, Alex Cherkasskiy, Yijun Li
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Publication number: 20080274556Abstract: Methods of evaluating molecular isomers of branched-chain amino acids are featured. The methods can include: derivatizing one or more molecular isomers of branched-chain amino acids in a sample comprising a branched-chain amino acid labeled with one or more heavy atoms as a first standard; adding, to the sample, after derivatization, a nonderivatized or derivatized branched chain amino acid that is labeled with one or more heavy atoms, as a second standard; evaluating the sample using tandem mass spectrometry; and detecting peaks indicative of derivatized and nonderivatized forms of one or more branched-chain amino acids in the sample.Type: ApplicationFiled: May 4, 2007Publication date: November 6, 2008Applicant: PerkinElmer LAS, Inc.Inventors: Blas Cerda, Alex Cherkasskiy, Yijun Li