Patents by Inventor Alex David Corwin
Alex David Corwin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20160170197Abstract: Approaches are disclosed for calibrating a plurality of imaging devices, such as microscopes. In certain implementations, a calibration plate is employed that includes a variety of calibration features. The calibration features comprise a geometric calibration, an illumination calibration, and an optical calibration. Imaging devices calibrated in accordance with the present approaches may be used to generate images having consistent attributes, such as brightness, regardless of which imaging device is employed.Type: ApplicationFiled: November 6, 2015Publication date: June 16, 2016Inventors: Kevin Bernard Kenny, Alex David Corwin, David Andrew Shoudy, Christine Lynne Surrette
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Publication number: 20160153868Abstract: A system for extracting material from a region of interest includes a fluid delivery base comprising an inlet channel and an outlet channel formed within the fluid delivery base; a gasket affixed to the fluid delivery base, wherein the gasket comprises at least one opening exposing an open end of the inlet channel and an open end of the outlet channel; a support comprising a sample-supporting surface facing the gasket and an opposing surface; and an alignment member coupled to the opposing surface in a fixed position and such that the support is positioned between the fluid delivery base and the alignment member, wherein one or both of the alignment member or the fluid delivery base are biased towards one another by a force (e.g., a magnet or spring force) and wherein the fluid delivery base is separable from the support and configured to move along a plane of the sample-supporting surface to align with the alignment member.Type: ApplicationFiled: December 1, 2014Publication date: June 2, 2016Inventors: John Richard Nelson, Wei Gao, Christopher Michael Puleo, Todd Frederick Miller, Christine Lynne Pitner, David Andrew Shoudy, Alex David Corwin
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Publication number: 20160147056Abstract: The invention provides a slide holder that utilizes edge detection algorithms to determine the location of various edges of a slide. From these edges, and integrating characteristic slide dimension, both linear offset of the edge of the slide in the holder and any rotation of the slide relative to the microscope stage axis are determined. The process of using the slide holder of the invention ensures precise and accurate placement of a slide during a first round of imaging and for reload in subsequent rounds.Type: ApplicationFiled: November 21, 2014Publication date: May 26, 2016Inventors: Alex David Corwin, Kevin Bernard Kenny, Christine Lynne Pitner
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Publication number: 20160061654Abstract: Approaches are disclosed for calibrating a plurality of imaging devices, such as microscopes. In certain implementations, a calibration plate is employed that include a variety of calibration features. Imaging devices calibrated in accordance with the present approaches may be used to generate images having consistent attributes, such as brightness, regardless of which imaging device is employed.Type: ApplicationFiled: August 26, 2014Publication date: March 3, 2016Inventors: Alex David Corwin, Christine Lynne Pitner, David Andrew Shoudy, Kevin Bernard Kenny
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Patent number: 9164015Abstract: A method for processing and imaging a first and second plurality of samples, comprising processing at least one sample from the first plurality of samples, imaging the at least one sample from the first plurality of samples, while being capable of simultaneously processing at least one sample from the second plurality of samples; and imaging the at least one processed sample from the second plurality of samples.Type: GrantFiled: June 29, 2012Date of Patent: October 20, 2015Assignee: General Electric CompanyInventors: Alex David Corwin, Robert John Filkins, Jun Xie, Nannan Chen, Kashan Ali Shaikh
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Publication number: 20150226743Abstract: A method of analyzing a biological sample suspected of having classic Hodgkin lymphoma, comprising (1) detecting, in a single sample, for the expression of at least two biomarkers selected from CD30, CD15, CD20, CD45, CD3, Pax-5, CD79A, BOB1 and OCT-2; and (b) analyzing the sample based on the presence, absence and/or expression level of the at least two biomarkers. Also provided is a method wherein all the nine biomarkers are analyzed on a single sample. Further provided are method for diagnosing classical Hodgkin lymphoma, as well as system and kit that comprise the means for executing the novel methods.Type: ApplicationFiled: May 30, 2013Publication date: August 13, 2015Applicant: CLARIENT DIAGNOSTICS SERVICES, INC.Inventors: Lawrence M. Weiss, Rodney A. Beck, Lakshmi Sireesha Kaanumalle, Antti E. Seppo, David Lavan Henderson, Alex David Corwin, Kevin Bernard Kenny, Colin Craig Mcculloch, Fiona Ginty, Alexanderr G. Bordwell, Michael S. Lazare, Denise A. Hollman-Hewgley
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Publication number: 20150198580Abstract: The invention provides a coverslip for automated decoverslipping of a tissue bearing slide comprising a horizontal base portion having a length, width, and height, at least two side wall portions extending downward from opposite sides of the base portion each having a length and width and h; and wherein the total wall volume to base volume ratio is greater than or equal to approximately 0.025.Type: ApplicationFiled: January 13, 2014Publication date: July 16, 2015Applicant: GENERAL ELECTRIC COMPANYInventors: Brian James Grimmond, Brian Christopher Bales, Alex David Corwin, Adriana Ines Larriera Moreno, Christine Lynne Pitner
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Publication number: 20150185453Abstract: A method for processing and imaging a first and second plurality of samples, comprising processing at least one sample from the first plurality of samples, imaging the at least one sample from the first plurality of samples, while being capable of simultaneously processing at least one sample from the second plurality of samples; and imaging the at least one processed sample from the second plurality of samples.Type: ApplicationFiled: June 26, 2013Publication date: July 2, 2015Inventors: Alex David Corwin, Robert John Filkins, Jun Xie, Nannan Chen, Kashan Ali Shaikh
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Publication number: 20150105283Abstract: A method for providing a composite image of a single biological sample from a patient suspected of having classical Hodgkin lymphoma, comprising the steps of generating a first image of the biological sample including the presence, absence and/or expression level of a first biomarker, generating a second image of the biological sample including the presence, absence and/or expression level of a second biomarker, and generating a composite image that provides the relative location or expression of both biomarkers. Also provided is a method of analyzing a biological sample, comprising providing a composite image of the biological sample according to the method for providing a composite image, and analyzing the expression of the biomarkers of interest from the composite image. Further provided are method for diagnosing classical Hodgkin lymphoma, as well as system and kit that comprise the means for executing the novel methods.Type: ApplicationFiled: May 30, 2013Publication date: April 16, 2015Applicant: CLARIENT DIAGNOSTICS SERVICES, INC.Inventors: Lawrence M. Weiss, Rodney A. Beck, Lakshmi Sireesha Kaanumalle, Antti E. Seppo, David Lavan Henderson, Alex David Corwin, Kevin Bernard Kenny, Colin Craig McCulloch, Fiona Ginty, Alexanderr G. Bordwell, Michael S. Lazare, Denise A. Hollman-Hewgley
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Patent number: 8900529Abstract: A microfluidic flow cell subassembly, which may be assembled into a flow cell having fluidic connections outside of the main substrate, is described for encapsulating a sample to allow for subsequent controlled delivery of reagents to the sample, such as multiplexed in situ biomarker staining and analysis. Methods for fabricating the subassembly and assembled flow cell are also provided. The method includes the steps of adhering a gasket layer to a substrate layer, wherein the gasket layer may contain enclosed features and adhering an adherent layer to the gasket layer. The subassembly may be sealed against a solid support to form a flow cell.Type: GrantFiled: April 27, 2012Date of Patent: December 2, 2014Assignee: General Electric CompanyInventors: Kashan Ali Shaikh, Jessica Marie Godin, Alex David Corwin, Robert John Filkins
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Publication number: 20140267671Abstract: Referencing of image acquired in multiple rounds of imaging is disclosed. In certain implementations, a baseline round of images are acquired and registered to one another to establish a global transformation matrix. In a subsequent round of image acquisition, a limited number of field of view images are initially acquired and registered to the corresponding baseline images to solve for translation, rotation, and scale. The full set of baseline images is then acquired for the subsequent round and each image is pre-rotated and pre-scaled based on the transform determined for the subset of images. The pre-rotated, pre-scaled images are then registered using a translation-only transform.Type: ApplicationFiled: March 18, 2013Publication date: September 18, 2014Applicant: GENERAL ELECTRIC COMPANYInventors: Kevin Bernard Kenny, Alex David Corwin
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Patent number: 8673643Abstract: A closed loop automated method for staining of a biological sample is provided. The method comprises providing a biological sample, staining at least a portion of the biological sample by flowing in a reagent, monitoring one or more optical characteristics of the biological sample, and calculating a figure of merit based on at least one of the optical characteristics. An automated device for iterative staining of a biological sample is also provided.Type: GrantFiled: November 30, 2010Date of Patent: March 18, 2014Assignee: General Electric CompanyInventors: Alex David Corwin, Robert John Filkins, Jun Xie, Christopher James Sevinsky, Kashan Ali Shaikh
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Publication number: 20140055853Abstract: An open top microfluidic device comprising a microfluidic slide carrier and one or more multiplexing stations is provided which allows sequential staining and imaging without the need for using or removing a coverslip on a mounted biological sample.Type: ApplicationFiled: August 27, 2012Publication date: February 27, 2014Applicant: GENERAL ELECTRIC COMPANYInventors: Alex David Corwin, Robert John Filkins, Kashan Ali Shaikh, Adriana Ines Larriera Moreno
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Publication number: 20140001337Abstract: A method for processing and imaging a first and second plurality of samples, comprising processing at least one sample from the first plurality of samples, imaging the at least one sample from the first plurality of samples, while being capable of simultaneously processing at least one sample from the second plurality of samples; and imaging the at least one processed sample from the second plurality of samples.Type: ApplicationFiled: June 29, 2012Publication date: January 2, 2014Applicant: GENERAL ELECTRIC COMPANYInventors: Alex David Corwin, Robert John Filkins, Jun Xie, Nannan Chen, Kashan Ali Shaikh
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Publication number: 20130287645Abstract: A microfluidic flow cell subassembly, which may be assembled into a flow cell having fluidic connections outside of the main substrate, is described for encapsulating a sample to allow for subsequent controlled delivery of reagents to the sample, such as multiplexed in situ biomarker staining and analysis. Methods for fabricating the subassembly and assembled flow cell are also provided. The method includes the steps of adhering a gasket layer to a substrate layer, wherein the gasket layer may contain enclosed features and adhering an adherent layer to the gasket layer. The subassembly may be sealed against a solid support to form a flow cell.Type: ApplicationFiled: April 27, 2012Publication date: October 31, 2013Applicant: General Electric CompanyInventors: Kashan Ali Shaikh, Jessica Marie Godin, Alex David Corwin, Robert John Filkins
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Patent number: 8354899Abstract: Provided is a device, such as a switch structure, that includes a contact and a conductive element that is configured to be deformable between a first position in which the conductive element is separated from the contact and a second position in which the conductive element contacts the contact. The conductive element can be formed substantially of metallic material configured to inhibit time-dependent deformation. For example, the metallic material may be configured to exhibit a maximum steady-state plastic strain rate of less than 10?12 s?1 when subject to a stress of at least about 25 percent of a yield strength of the metallic material and a temperature less than or equal to about half of a melting temperature of the metallic material. The contact and the conductive element may be part of a microelectromechanical device or a nanoelectromechanical device. Associated methods are also provided.Type: GrantFiled: September 23, 2009Date of Patent: January 15, 2013Assignee: General Electric CompanyInventors: Christopher Fred Keimel, Marco Francesco Aimi, Shubhra Bansal, Reed Roeder Corderman, Kuna Venkat Satya Rama Kishore, Eddula Sudhakar Reddy, Atanu Saha, Kanakasabapathi Subramanian, Parag Thakre, Alex David Corwin
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Publication number: 20120135458Abstract: A closed loop automated method for staining of a biological sample is provided. The method comprises providing a biological sample, staining at least a portion of the biological sample by flowing in a reagent, monitoring one or more optical characteristics of the biological sample, and calculating a figure of merit based on at least one of the optical characteristics. An automated device for iterative staining of a biological sample is also provided.Type: ApplicationFiled: November 30, 2010Publication date: May 31, 2012Applicant: GENERAL ELECTRIC COMPANYInventors: Alex David Corwin, Robert John Filkins, Jun Xie, Christopher James Sevinsky, Kashan Ali Shaikh
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Patent number: 8093971Abstract: A micro electromechanical system switch having an electrical pathway is presented. The switch includes a first portion and a second portion. The second portion is offset to a zero overlap position with respect to the first portion when the switch is in open position (or in the closed position depending on the switch architecture). The switch further includes an actuator for moving the first portion and the second portion into contact.Type: GrantFiled: December 22, 2008Date of Patent: January 10, 2012Assignee: General Electric CompanyInventors: Xuefeng Wang, Alex David Corwin, Bo Li, Kanakasabapathi Subramanian, Kuna Venkat Satya Rama Kishore
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Publication number: 20110067983Abstract: Provided is a device, such as a switch structure, that includes a contact and a conductive element that is configured to be deformable between a first position in which the conductive element is separated from the contact and a second position in which the conductive element contacts the contact. The conductive element can be formed substantially of metallic material configured to inhibit time-dependent deformation. For example, the metallic material may be configured to exhibit a maximum steady-state plastic strain rate of less than 10?12 s?1 when subject to a stress of at least about 25 percent of a yield strength of the metallic material and a temperature less than or equal to about half of a melting temperature of the metallic material. The contact and the conductive element may be part of a microelectromechanical device or a nanoelectromechanical device. Associated methods are also provided.Type: ApplicationFiled: September 23, 2009Publication date: March 24, 2011Applicant: GENERAL ELECTRIC COMPANYInventors: Christopher Fred Keimel, Marco Francesco Aimi, Shubhra Bansal, Reed Roeder Corderman, Kuna Venkat Satya Rama Kishore, Eddula Sudhakar Reddy, Atanu Saha, Kanakasabapathi Subramanian, Parag Thakre, Alex David Corwin
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Publication number: 20100155203Abstract: A micro electromechanical system switch having an electrical pathway is presented. The switch includes a first portion and a second portion. The second portion is offset to a zero overlap position with respect to the first portion when the switch is in open position (or in the closed position depending on the switch architecture). The switch further includes an actuator for moving the first portion and the second portion into contact.Type: ApplicationFiled: December 22, 2008Publication date: June 24, 2010Applicant: GENERAL ELECTRIC COMPANYInventors: Xuefeng Wang, Alex David Corwin, Bo Li, Kanakasabapathi Subramanian, Kuna Venkat Satya Rama Kishore