Abstract: Provided herein are novel anti-CD28×anti-ENPP3 antibodies and methods of using such antibodies for the treatment of ENPP3-associated cancers. Subject anti-CD28×anti-ENPP3 antibodies are capable of agonistically binding to CD28 costimulatory molecules on T cells and ENPP3 on tumor cells. Thus, such antibodies selectively enhance anti-tumor activity at tumor sites while minimizing peripheral toxicity. The subject antibodies provided herein are particularly useful in combination with other anti-cancer therapies, including, for example, bispecific antibodies for the treatment of ENPP3-associated cancers.

Abstract: A portable playground system including a cylindrical base member having four openings therethrough disposed at ninety degree intervals therearound intermediate upper and lower ends thereof. The base member has a floor disposed interiorly thereof disposed at lower ends of the four openings. A top member is dimensioned for removable coupling with the upper end of the cylindrical base member. Stairs, ladders and slides are adapted for removably coupling with the four openings.