Patents by Inventor Alex Franzusoff

Alex Franzusoff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Primary cell gene editing
    Patent number: 10711283
    Abstract: Methods and compositions are provided for nuclease-mediated gene editing of primary cells without the use of viral mediated delivery. Methods of treatments using edited primary cells are also provided.
    Type: Grant
    Filed: February 5, 2020
    Date of Patent: July 14, 2020
    Assignee: PACT PHARMA, INC.
    Inventors: Kyle Jacoby, Alex Franzusoff
  • PRIMARY CELL GENE EDITING
    Publication number: 20200181650
    Abstract: Methods and compositions are provided for nuclease-mediated gene editing of primary cells without the use of viral mediated delivery. Methods of treatments using edited primary cells are also provided.
    Type: Application
    Filed: February 5, 2020
    Publication date: June 11, 2020
    Applicant: PACT PHARMA, INC.
    Inventors: Kyle Jacoby, Alex Franzusoff
  • Primary cell gene editing
    Patent number: 10676758
    Abstract: Methods and compositions are provided for nuclease-mediated gene editing of primary cells without the use of viral mediated delivery. Methods of treatments using edited primary cells are also provided.
    Type: Grant
    Filed: February 5, 2020
    Date of Patent: June 9, 2020
    Assignee: PACT PHARMA, INC.
    Inventors: Kyle Jacoby, Alex Franzusoff
  • PRIMARY CELL GENE EDITING
    Publication number: 20200165634
    Abstract: Methods and compositions are provided for nuclease-mediated gene editing of primary cells without the use of viral mediated delivery. Methods of treatments using edited primary cells are also provided.
    Type: Application
    Filed: February 5, 2020
    Publication date: May 28, 2020
    Applicant: PACT PHARMA, INC.
    Inventors: Kyle Jacoby, Alex Franzusoff
  • Primary cell gene editing
    Patent number: 10584357
    Abstract: Methods and compositions are provided for nuclease-mediated gene editing of primary cells without the use of viral mediated delivery. Methods of treatments using edited primary cells are also provided.
    Type: Grant
    Filed: August 27, 2019
    Date of Patent: March 10, 2020
    Assignee: PACT PHARMA, INC.
    Inventors: Kyle Jacoby, Alex Franzusoff
  • Combination Immunotherapy Compositions Against Cancer and Methods
    Publication number: 20200069784
    Abstract: Disclosed are immunotherapeutic compositions and the concurrent use of combinations of such compositions for the improved induction of therapeutic immune responses and/or for the prevention, amelioration and/or treatment of disease, including, but not limited to, cancer and infectious disease.
    Type: Application
    Filed: July 1, 2019
    Publication date: March 5, 2020
    Inventors: James Hodge, Jeffrey Schlom, Alex Franzusoff
  • Primary cell gene editing
    Patent number: 10550406
    Abstract: Methods and compositions are provided for nuclease-mediated gene editing of primary cells without the use of viral mediated delivery. Methods of treatments using edited primary cells are also provided.
    Type: Grant
    Filed: August 27, 2019
    Date of Patent: February 4, 2020
    Assignee: PACT PHARMA, INC.
    Inventors: Kyle Jacoby, Alex Franzusoff
  • PRIMARY CELL GENE EDITING
    Publication number: 20190376086
    Abstract: Methods and compositions are provided for nuclease-mediated gene editing of primary cells without the use of viral mediated delivery. Methods of treatments using edited primary cells are also provided.
    Type: Application
    Filed: August 27, 2019
    Publication date: December 12, 2019
    Applicant: PACT PHARMA, INC.
    Inventors: KYLE JACOBY, ALEX FRANZUSOFF
  • PRIMARY CELL GENE EDITING
    Publication number: 20190376091
    Abstract: Methods and compositions are provided for nuclease-mediated gene editing of primary cells without the use of viral mediated delivery. Methods of treatments using edited primary cells are also provided.
    Type: Application
    Filed: August 27, 2019
    Publication date: December 12, 2019
    Applicant: PACT PHARMA, INC.
    Inventors: Kyle Jacoby, Alex Franzusoff
  • Combination immunotherapy compositions against cancer and methods
    Patent number: 10383924
    Abstract: Disclosed are immunotherapeutic compositions and the concurrent use of combinations of such compositions for the improved induction of therapeutic immune responses and/or for the prevention, amelioration and/or treatment of disease, including, but not limited to, cancer and infectious disease.
    Type: Grant
    Filed: April 16, 2010
    Date of Patent: August 20, 2019
    Assignees: GlobeImmune, Inc., The USA, as represented by the Secretary, Dept. of Health and Human Services
    Inventors: James Hodge, Jeffrey Schlom, Alex Franzusoff
  • YEAST-MUC1 IMMUNOTHERAPEUTIC COMPOSITIONS AND USES THEREOF
    Publication number: 20190231859
    Abstract: Disclosed are yeast-based immunotherapeutic compositions comprising mucin-1 (MUC1), as well as methods for the prevention and/or treatment of cancers characterized by the expression or overexpression of mucin-1 (MUC1).
    Type: Application
    Filed: December 6, 2018
    Publication date: August 1, 2019
    Inventors: Alex Franzusoff, Zhimin Guo, Jeffrey Schlom, Kwong-Yok Tsang
  • Yeast-MUC1 immunotherapeutic compositions and uses thereof
    Patent number: 10188714
    Abstract: Disclosed are yeast-based immunotherapeutic compositions comprising mucin-1 (MUC1), as well as methods for the prevention and/or treatment of cancers characterized by the expression or overexpression of mucin-1 (MUC1).
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: January 29, 2019
    Assignees: GlobeImmune, Inc., The United States of America, as represented by the Secretary, Dept. of Health and Human Services
    Inventors: Alex Franzusoff, Zhimin Guo, Jeffrey Schlom, Kwong-Yok Tsang
  • Methods for delivering cromolyn
    Patent number: 9861608
    Abstract: Methods of delivering cromolyn to a patient in need thereof, methods of treating amyloid-associated conditions and inflammatory or allergic lung diseases, and blister packs and kits comprising cromolyn are described.
    Type: Grant
    Filed: May 22, 2014
    Date of Patent: January 9, 2018
    Assignee: AZTHERAPIES, INC
    Inventors: David R. Elmaleh, Alex Franzusoff
  • Combination Therapy for Treating Cancer with a Poxvirus Expressing a Tumor Antigen and an Antagonist and/or Agonist of an Immune Checkpoint Inhibitor
    Publication number: 20170266270
    Abstract: The invention relates to compositions, kits, and methods for cancer therapy using recombinant poxviruses encoding a tumor-associated antigen in combination with antagonists or agonists of immune checkpoint inhibitors.
    Type: Application
    Filed: May 8, 2015
    Publication date: September 21, 2017
    Applicant: Bavarian Nordic A/S
    Inventors: SUSAN FOY, STEFANIE MANDL, RYAN ROUNTREE, ALEX FRANZUSOFF
  • YEAST-MUC1 IMMUNOTHERAPEUTIC COMPOSITIONS AND USES THEREOF
    Publication number: 20170224794
    Abstract: Disclosed are yeast-based immunotherapeutic compositions comprising mucin-1 (MUC1), as well as methods for the prevention and/or treatment of cancers characterized by the expression or overexpression of mucin-1 (MUC1).
    Type: Application
    Filed: November 22, 2016
    Publication date: August 10, 2017
    Inventors: Alex Franzusoff, Zhimin Guo, Jeffrey Schlom, Kwong-Yok Tsang
  • Methods for producing yeast-based vaccines
    Patent number: 9549970
    Abstract: The invention provides methods for culturing yeast at a neutral pH level. Yeast cultured under neutral pH conditions exhibit desirable characteristics useful for biological purposes, such as the development of vaccines, prophylactics and therapeutics. The invention also provides for compositions and kits comprising yeast grown using the methodologies disclosed herein.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: January 24, 2017
    Assignee: GlobeImmune, Inc.
    Inventors: Alex Franzusoff, Deborah Quick
  • Yeast-MUC1 immunotherapeutic compositions and uses thereof
    Patent number: 9533031
    Abstract: Disclosed are yeast-based immunotherapeutic compositions comprising mucin-1 (MUC1), as well as methods for the prevention and/or treatment of cancers characterized by the expression or overexpression of mucin-1 (MUC1).
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: January 3, 2017
    Assignees: GlobeImmune, Inc., The United States of America, as represented by the Secretary, Dept. of Health and Human Services
    Inventors: Alex Franzusoff, Zhimin Guo, Jeffrey Schlom, Kwong-Yok Tsang
  • METHODS FOR DELIVERING CROMOLYN
    Publication number: 20160106704
    Abstract: Methods of delivering cromolyn to a patient in need thereof, methods of treating amyloid-associated conditions and inflammatory or allergic lung diseases, and blister packs and kits comprising cromolyn are described.
    Type: Application
    Filed: May 22, 2014
    Publication date: April 21, 2016
    Applicant: AZTHERAPIES, INC
    Inventors: DAVID R. ELMALEH, ALEX FRANZUSOFF
  • CELL PENETRATING COMPOSITIONS FOR DELIVERY OF INTRACELLULAR ANTIBODIES AND ANTIBODY-LIKE MOIETIES AND METHODS OF USE
    Publication number: 20150266939
    Abstract: The disclosure relates to a complex comprising a Surf+ Penetrating Polypeptide and an AAM moiety for intracellular delivery, and methods of use.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 24, 2015
    Inventors: Erik M. Vogan, Alex Franzusoff, John Edwards, Ann DeWitt
  • Yeast-based vaccines
    Patent number: 9066893
    Abstract: The invention provides methods for culturing yeast at a neutral pH level. Yeast cultured under neutral pH conditions exhibit desirable characteristics useful for biological purposes, such as the development of vaccines, prophylactics and therapeutics. The invention also provides for compositions and kits comprising yeast grown using the methodologies disclosed herein.
    Type: Grant
    Filed: February 1, 2008
    Date of Patent: June 30, 2015
    Assignee: GlobelImmune, Inc.
    Inventors: Alex Franzusoff, Deborah Quick