Abstract: A system for treatment of intracranial stenosis can include a catheter having a lumen, and an elongate member extending through the lumen. A distal pressure sensor is coupled to a distal end portion of the elongate member and is configured to obtain blood pressure parameters to characterize blood flow at a treatment site before and after treatment. A stent is disposed within the catheter lumen in a radially constrained configuration. The stent surrounds the elongate member such that the distal end portion of the elongate member is disposed distal to a distal end of the stent. The stent is configured to radially expand into apposition with the blood vessel to increase blood flow at the treatment site when released from the catheter.