Abstract: The present disclosure relates to systems and methods for assessing severity of involuntary movement associated with tardive dyskinesia (TD). The method includes receiving video data of the patient. The video data may include facial movements of the patient. The method includes processing the video data to identify facial landmark data of the patient, which may include applying an image processing technique to the video data to identify facial landmarks on one or more frames of the video data to produce labeled frames. The method may include applying a plurality of trained machine learning models to the facial landmark data to determine one or more movement severity scores based on changes in the facial landmark data of the patient, where each movement severity score is representative of a category of facial movement, and a total severity score may be generated based on multiple movement severity scores.