Abstract: The present invention provides 2-pyrimidinyl pyrazolopyridine compounds, compositions containing the same, as well as processes for the preparation and their use as pharmaceutical agents.

Abstract: The present invention provides imidazopyridine compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.

Abstract: The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.

Abstract: The present invention provides 2-pyrimidinyl pyrazolopyridine compounds, compositions containing the same, as well as processes for the preparation and their use as pharmaceutical agents.

Abstract: The present invention provides imidazopyridine compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.

Abstract: An adjustable string tree provides selectable adjustment for tension on a stringed musical instrument. A back plate is fixed to a base plate, which in turn is fixed to the musical instrument. A top plate adjustably and slidably engages the back plate in order to exert tension on a string. Adjustment may be provided by an adjustment bolt in opposition to a compression spring. In a preferred embodiment, an indentation is provided in the top plate in alignment with the string to better hold the string in association with the top plate.

Abstract: An adjustable string tree provides selectable adjustment for tension on a stringed musical instrument. A back plate is fixed to a base plate, which in turn is fixed to the musical instrument. A top plate adjustably and slidably engages the back plate in order to exert tension on a string. Adjustment may be provided by an adjustment bolt in opposition to a compression spring. In a preferred embodiment, an indentation is provided in the top plate in alignment with the string to better hold the string in association with the top plate.

Abstract: A musical system for stringed instruments based on tuning in fifths in conjunction with component control reduces dissonance and discord while increasing harmony and consonance. In a stringed instrument, the main music-making portion of the string serves to drive the other non-music-making portions or supporting portions of the string. This is particularly true at the end of the string past the stop point toward the fixed end and upward past the nut towards the turnable post controlled by a key. By appropriately selecting and providing adjustment for the stop point, as well as the length of the strings past the bridge, less dissonance arises from the individual string as it is played. A string retainer or the like, as well as a compound head, may serve to provide adjustable or selectable means by which tension on a plurality of strings may be adjusted to provide uniform tension between individual strings. Tuning in fifths provides inter-string harmony.

Abstract: A multi-plane headstock provides different planes to which strings of a stringed musical instrument may be attached to control the tension on the string and the angle at which the string breaks from the plane of the strings over the fingerboard. Advantageous musical characteristics are provided to such stringed musical instruments by implementation of the multi-planed headstock of the present invention in greater selectability and adjustability of stringed musical instrument characteristics, as well as increased internal harmony of the instrument.

Abstract: A multi-plane headstock provides different planes to which strings of a stringed musical instrument may be attached to control the tension on the string and the angle at which the string breaks from the plane of the strings over the fingerboard. Advantageous musical characteristics are provided to such stringed musical instruments by implementation of the multi-planed headstock of the present invention in greater selectability and adjustability of stringed musical instrument characteristics, as well as increased internal harmony of the instrument.

Abstract: An adjustable string tree provides selectable adjustment for tension on a stringed musical instrument. A back plate is fixed to a base plate, which in turn is fixed to the musical instrument. A top plate adjustably and slidably engages the back plate in order to exert tension on a string. Adjustment may be provided by an adjustment bolt in opposition to a compression spring. In a preferred embodiment, an indentation is provided in the top plate in alignment with the string to better hold the string in association with the top plate.

Abstract: A musical system for stringed instruments based on tuning in fifths in conjunction with component control reduces dissonance and discord while increasing harmony and consonance. In a stringed instrument, the main music-making portion of the string serves to drive the other non-music-making portions or supporting portions of the string. This is particularly true at the end of the string past the stop point toward the fixed end and upward past the nut towards the turnable post controlled by a key. By appropriately selecting and providing adjustment for the stop point, as well as the length of the strings past the bridge, less dissonance arises from the individual string as it is played. A string retainer or the like, as well as a compound head, may serve to provide adjustable or selectable means by which tension on a plurality of strings may be adjusted to provide uniform tension between individual strings. Tuning in fifths provides inter-string harmony.

Abstract: A five-string guitar is tuned in fifths to provide better sound. A five-string guitar is tuned in fifths to provide better sound by providing better harmonic separation of the notes played and by reducing “muddiness” or lack of clarity in the heard note. A number of realized embodiments enable the five-string guitar to accommodate a wide variety of stringed-instrument musical needs and preferences.

Abstract: A compound headstock for use with a guitar-like instrument. The headstock has a major surface to which posts of a majority of the headmachines mounted on the headstock project. The headstock also preferably incudes first and second surfaces disposed at elevations different than the elevation of the major surface. Through the first and second surfaces are disposed the posts of headmachines associated with the lowest and highest tuned strings used on the guitar-like instrument. As such, the string associated with the lowest tuned note makes an angle with respect to the plane in which the strings set between a nut on the guitar-like instrument and a bridge on a guitar-like instrument which is much greater than the angles made for the majority of the strings. Similarly, the string associated with the highest tuned note makes an angle with respect to said plane which is much less than the angles associated with the stings associated with the majority of the headmachines.

Abstract: A stringed instrument comprising a body and a neck, the neck having a fingerboard and a headstock and being mounted on the body and also including relatively high frets on the fingerboard. Tuning machines are mounted on the headstock and a vibrato bridge unit is mounted on the body. Strings urge the vibrato bridge unit into a quiescent, non-vibrato position. Strings are mounted between the tuning machines and the vibrato bridge unit. Strings are mounted between the tuning machines in the vibrato bridge unit, the neck having approximately a fourteen inch scale length and the strings being tuned like a violin to the notes G, D, A and E. A pick-up arrangement is mounted on the body, preferably having pole pieces which confront the strings.