Patents by Inventor Alex Hartov
Alex Hartov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9456200Abstract: A system for, and method of, extracting a surface profile from a stereo pair of images obtained at an arbitrary setting S of an optical system, includes determining surface profile reconstruction parameters for images obtained with the optical system at a reference setting So of the optical system; determining warping parameters for a digital image processor for warping images obtained with the optical system at the arbitrary setting S into images corresponding to the reference setting So; obtaining the stereo pair of images from at least one camera of the optical system; warping the stereo pair of images into images corresponding to the reference setting So, and using the surface profile reconstruction parameters to determine the surface profile. In a particular embodiment, the surface profile is passed to a computer model of tissue deformation and used to determine an intra-surgery location of a tumor or other anatomic feature of tissue.Type: GrantFiled: January 4, 2013Date of Patent: September 27, 2016Assignee: THE TRUSTEES OF DARTMOUTH COLLEGEInventors: Songbai Ji, Xiaoyao Fan, Keith D. Paulsen, David W. Roberts, Alex Hartov
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Patent number: 9336592Abstract: A system and method for determining intraoperative locations of a lesion in tissue from lesion locations determined in preoperative imaging includes determining three dimensional locations of surface features of the organ in the preoperative images. A preoperative surface map is extracted from stereo images annotated with surface features from preoperative images. An intraoperative surface map of the organ is extracted from stereo images, and surface features are identified in the stereo images corresponding to surface features annotated into the preoperative surface map. Three dimensional displacements of the surface features are determined and used to constrain a computer model of deformation of the organ. In embodiments, the model of deformation is adapted or constrained to model locations and dimensions of surgical cavities using an optical flow method and/or locations of surgical instruments in the organ. The model of deformation is used to determine intraoperative locations for the lesion.Type: GrantFiled: February 1, 2013Date of Patent: May 10, 2016Assignee: THE TRUSTEES OF DARTMOUTH COLLEGEInventors: Xiaoyao Fan, David W. Roberts, Keith D. Paulsen, Songbai Ji, Alex Hartov
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Patent number: 9179888Abstract: A method for providing patient registration without fiducials comprises the steps of: spatially placing an ultrasound image of a patient randomly at different starting positions relative to a preoperative image; creating an independent registration corresponding to each different starting positions, by optimizing a spatial transformation between the preoperative image and the ultrasound image to provide a first batch of registrations; executing a second registration to fine-tune the alignment between the preoperative image and the ultrasound image; and concatenating the spatial transformation to obtain spatial transformation between the patient in an operating room and a corresponding preoperative image.Type: GrantFiled: August 27, 2010Date of Patent: November 10, 2015Assignee: Dartmouth CollegeInventors: Songbai Ji, David W. Roberts, Alex Hartov, Keith D. Paulsen
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Patent number: 9098904Abstract: A system and methods are presented for emulating the appearance of prominent features captured in ultrasound through directional dilation of a magnetic resonance gradient image along a direction determined by the relative ultrasound scan-head location with respect to the magnetic resonance gradient image in order to improve the robustness and reliability of registration.Type: GrantFiled: November 15, 2011Date of Patent: August 4, 2015Assignee: Dartmouth CollegeInventors: Songbai Ji, David W. Roberts, Alex Hartov, Keith D. Paulsen
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Patent number: 8948851Abstract: A tomographic fluorescent imaging device for imaging fluorophores in biological tissues has a scanned laser for scanning the tissue and a camera for receiving light from the biological tissue at an angle to the beam at a second wavelength ten or more nanometers greater in wavelength than the wavelength of the laser. Use of both intrinsic and extrinsic fluorophores is described. Images are obtained at each of several positions of the beam. An image processing system receives the series of images, models a path of the beam through the tissue, and determines depth of fluorophore in tissue from intersections of the modeled path of the beam and the path of the received light. The laser is of 600 nm or longer wavelength, to provide penetration of tissue. The imaging device is used during surgery to visualize lesions of various types to ensure complete removal of malignant tumors.Type: GrantFiled: December 4, 2009Date of Patent: February 3, 2015Assignee: The Trustees of Dartmouth CollegeInventors: Frederic Leblond, David W. Roberts, Brian W. Pogue, Keith D. Paulsen, Alex Hartov, Scott C. Davis, Dax Kepshire
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Publication number: 20140369584Abstract: A system and method for determining intraoperative locations of a lesion in tissue from lesion locations determined in preoperative imaging includes determining three dimensional locations of surface features of the organ in the preoperative images. A preoperative surface map is extracted from stereo images annotated with surface features from preoperative images. An intraoperative surface map of the organ is extracted from stereo images, and surface features are identified in the stereo images corresponding to surface features annotated into the preoperative surface map. Three dimensional displacements of the surface features are determined and used to constrain a computer model of deformation of the organ. In embodiments, the model of deformation is adapted or constrained to model locations and dimensions of surgical cavities using an optical flow method and/or locations of surgical instruments in the organ. The model of deformation is used to determine intraoperative locations for the lesion.Type: ApplicationFiled: February 1, 2013Publication date: December 18, 2014Inventors: Xiaoyao Fan, David W. Roberts, Keith D. Paulsen, Songbai Ji, Alex Hartov
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Publication number: 20140362186Abstract: A system for, and method of, extracting a surface profile from a stereo pair of images obtained at an arbitrary setting S of an optical system, includes determining surface profile reconstruction parameters for images obtained with the optical system at a reference setting So of the optical system; determining warping parameters for a digital image processor for warping images obtained with the optical system at the arbitrary setting S into images corresponding to the reference setting So; obtaining the stereo pair of images from at least one camera of the optical system; warping the stereo pair of images into images corresponding to the reference setting So, and using the surface profile reconstruction parameters to determine the surface profile. In a particular embodiment, the surface profile is passed to a computer model of tissue deformation and used to determine an intra-surgery location of a tumor or other anatomic feature of tissue.Type: ApplicationFiled: January 4, 2013Publication date: December 11, 2014Applicant: THE TRUSTEES OF DARTMOUTH COLLEGEInventors: Songbai Ji, Xiaoyao Fan, Keith D. Paulsen, David W. Roberts, Alex Hartov
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Patent number: 8886291Abstract: A dual imaging probe 300 for obtaining both ultrasound and electrical impedance data is disclosed along with methods of using the dual imaging probe 300 to interrogate tissue. An electrical impedance imaging overlay 330 is adapted to be positioned on a transducer window 304 of an ultrasound probe 320, and may be integrally formed as part of the ultrasound probe 320 or as a modular adapter for coupling with, and optionally uncoupling from, an ultrasound probe 320 to form the dual imaging probe 300. A method (FIG. 6) of reconstructing composite images using both ultrasound and electrical impedance data is described. Applications for medical diagnosis are described. A particular use for prostate imaging is described.Type: GrantFiled: January 7, 2009Date of Patent: November 11, 2014Assignee: The Trustees of Dartmouth CollegeInventors: Alex Hartov, Keith D. Paulsen
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Publication number: 20140056498Abstract: A system and methods are presented for emulating the appearance of prominent features captured in ultrasound through directional dilation of a magnetic resonance gradient image along a direction determined by the relative ultrasound scan-head location with respect to the magnetic resonance gradient image in order to improve the robustness and reliability of registration.Type: ApplicationFiled: November 15, 2011Publication date: February 27, 2014Applicant: Dartmouth CollegeInventors: Songbai Ji, David W. Roberts, Alex Hartov, Keith D. Paulsen
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Publication number: 20120215093Abstract: A method for providing patient registration without fiducials comprises the steps of: spatially placing an ultrasound image of a patient randomly at different starting positions relative to a preoperative image; creating an independent registration corresponding to each different starting positions, by optimizing a spatial transformation between the preoperative image and the ultrasound image to provide a first batch of registrations; executing a second registration to fine-tune the alignment between the preoperative image and the ultrasound image; and concatenating the spatial transformation to obtain spatial transformation between the patient in an operating room and a corresponding preoperative image.Type: ApplicationFiled: August 27, 2010Publication date: August 23, 2012Applicant: Dartmouth CollegeInventors: Songbai Ji, David W. Roberts, Alex Hartov, Keith D. Paulsen
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Publication number: 20110275932Abstract: A tomographic fluorescent imaging device for imaging fluorophores in biological tissues has a scanned laser for scanning the tissue and a camera for receiving light from the biological tissue at an angle to the beam at a second wavelength ten or more nanometers greater in wavelength than the wavelength of the laser. Use of both intrinsic and extrinsic fluorophores is described. Images are obtained at each of several positions of the beam. An image processing system receives the series of images, models a path of the beam through the tissue, and determines depth of fluorophore in tissue from intersections of the modeled path of the beam and the path of the received light. The laser is of 600 nm or longer wavelength, to provide penetration of tissue. The imaging device is used during surgery to visualize lesions of various types to ensure complete removal of malignant tumors.Type: ApplicationFiled: December 4, 2009Publication date: November 10, 2011Inventors: Frederic Leblond, David W. Roberts, Brian W. Pogue, Keith D. Paulsen, Alex Hartov, Scott C. Davis, Dax Kepshire
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Publication number: 20110034806Abstract: A dual imaging probe 300 for obtaining both ultrasound and electrical impedance data is disclosed along with methods of using the dual imaging probe 300 to interrogate tissue. An electrical impedance imaging overlay 330 is adapted to be positioned on a transducer window 304 of an ultrasound probe 320, and may be integrally formed as part of the ultrasound probe 320 or as a modular adapter for coupling with, and optionally uncoupling from, an ultrasound probe 320 to form the dual imaging probe 300. A method (FIG. 6) of reconstructing composite images using both ultrasound and electrical impedance data is described. Applications for medical diagnosis are described. A particular use for prostate imaging is described.Type: ApplicationFiled: January 7, 2009Publication date: February 10, 2011Applicant: THE TRUSTEES OF DARTMOUTH COLLEGEInventors: Alex Hartov, Keith D. Paulsen