Abstract: A pressurised refill canister containing a reservoir of composition including a propellant and a nicotine or a pharmaceutically acceptable derivative or salt thereof. The reservoir is at a pressure of greater than 400 kPa at 20° C. A refill outlet valve comprises a stem with an axial bore open at the axial end furthest from the reservoir to provide an outlet which discharges the composition in an axial direction. The stem is displaceable from a closed position to which it is biased by a first resilient member with a spring force of greater than 10N when no external force is applied to a dispensing position against the action of the first resilient member to open a flow path from the reservoir to the outlet.

Abstract: An inhaler comprising a reservoir of an inhalable composition with an outlet at one end through which the inhalable composition is discharged. A non-metered breath-activated valve is provided between the one end and the reservoir, the breath-activated valve comprising a flow path extending from the reservoir to the outlet end. At least a portion of the flow path is a deformable tube. A clamping member pinches the deformable tube closed when no suction force is applied to the device and releases the tube to open the flow path when suction is applied at the outlet, to provide uninterrupted flow from the reservoir to the outlet.

Abstract: A simulated cigarette having a generally cylindrical cigarette like housing with a main axis, the housing containing a reservoir of a pressurised inhalable composition. The reservoir has a reservoir outlet at one end which is selectively closed by an outlet valve. The simulated cigarette further comprises a tube with a through bore extending along a substantial portion of the reservoir from the vicinity of the reservoir outlet such that composition flows into a tube bore inlet and along the tube bore to the reservoir outlet. The tube inlet end is retained such that the axis passes through the inlet end and so that the tube bore inlet is positioned in the axial sense in the central 50% of the volume of the reservoir.

Abstract: A simulated smoking device comprising a simulated cigarette having a cigarette-like shape and a refill device. A drawer is provided in the side of the refill device with a recess for the simulated cigarette. A resilient member biases the drawer open to allow access to the simulated cigarette. A latch is releasable by an inward movement of the drawer whereupon the drawer is unlatched and urged by the resilient member to the open position. The latch is automatically engageable upon closure of the drawer to hold the drawer in a closed position against the action of the resilient member.

Abstract: A simulated cigarette comprising a housing having a generally cigarette-like shape and size; a reservoir within the housing configured to receive and contain a dose of inhalable formulation; a means for controlling the flow from the reservoir; an outlet passage from the means for controlling the flow from the reservoir to an outlet in the housing from which outlet a user inhales the formulation, wherein a deliverable daily dose of inhalable formulation is delivered by pulmonary administration using one or more of said simulated cigarette, wherein said deliverable daily dose comprises less than 60 mg of nicotine or a pharmaceutically acceptable salt thereof.

Abstract: A simulated cigarette includes a housing having a generally cigarette-like shape and size; a reservoir of inhalable composition within the housing; an actuator controlling the flow from the reservoir; and an outlet passage from the actuator to an outlet in the housing from which outlet a user inhales the composition, wherein the housing adjacent to the outlet end has a deformable material at its outer periphery.

Abstract: A simulated cigarette includes a housing having a generally cigarette-like shape and size; a reservoir of inhalable composition within the housing; an actuator controlling the flow of the inhalable composition from the reservoir; an outlet passage from the actuator to an outlet in the housing from which outlet a user inhales the composition; and a chemical heater provided adjacent to the outlet passage and arranged to be activated to undergo an exothermic reaction to heat the inhalable composition as it travels along the outlet passage.

Abstract: An inhaler comprising a reservoir of inhalable composition, an outlet valve to control the flow of composition from the reservoir, the valve outlet orifice having a maximum dimension h, measured in the direction of opening when fully opened; an expansion chamber downstream of the valve having a length L and diameter D measured half way along the expansion chamber; and an exit orifice at the downstream end of the expansion chamber, the orifice having a length l and a diameter d; wherein 0.1<h/d<1.0; 0.05<h/D<0.25; 1<D/d<10; 5<L/D<15; 0.1<l/d<5.

Abstract: A pressurised refill canister containing a composition including a propellant. The canister has an outlet valve having a stem biased to a closed position by a first resilient member. The stem has a maximum outer diameter of greater than 3 mm. At the outlet end of the stem, at least part of the wall of the stem extends inwardly from the outside diameter for at least 50% of the radius.

Abstract: A method of assembling a tubular simulated cigarette, the method comprising providing an elongate hollow housing having an inhaling end and a refill end; inserting an outlet valve tube, a dip tube and a support from the refill end so that the support supports the proximal end of the dip tube in the housing; inserting a refill valve into the refill end and fixing it in place to form a composition reservoir with the dip tube placing the reservoir in fluid communication with an outlet orifice when the outlet valve tube is open; inserting a valve element into a recess in the side of the housing so that the valve element is positioned to selectively close the outlet valve tube; inserting a breath operated valve actuation mechanism laterally into the recess; and applying a cover to the recess.

Abstract: A pressurised refill canister containing a reservoir of composition including a propellant, and a non-metered refill outlet valve comprising a stem displaceable from a first position to a dispensing position against the action of a resilient member. The stem comprises a blind bore open at an outlet end and closed at the opposite end and a lateral bore in the side wall of the stem leading to the blind bore. The refill outlet valve further comprises an annular seal which surrounds the stem whereby, in the first position, the lateral bore is not in communication with the inside of the canister, and in the dispensing position, the lateral bore is arranged to move inside the canister with respect to the seal to open a flow path from the inside of the canister via the lateral bore and along the blind bore to the outlet end.

Abstract: The invention relates to dosage regimens for an inhalable formulation comprising nicotine, and to devices for delivering said dosage regimens.

Abstract: A simulated smoking device (1) comprising a simulated cigarette having a substantially cylindrical cigarette-like shape and a refill device (2, 50) having a substantially cuboid housing with a cigarette pack-like shape containing refill gas (32, 59) for the simulated cigarette and having means for selectively retaining the simulated cigarette. The simulated cigarette may be retained wholly within the housing. It may be retained at a location different from the refill location. A dose counter may be provided to give a visual indication of the doses in the refill device.

Abstract: An inhalable composition comprising: nicotine or a pharmaceutically acceptable derivative or salt thereof; a propellant; a monohydric alcohol; and a glycol and/or glycol ether, characterised in that the ratio of monohydric alcohol:glycol or glycol ether by weight is from 6:1 to 1:1.

Abstract: An inhaler comprising a source of inhalable composition. An outlet flow path is provided for the composition from the source to a composition outlet at an outlet end of the inhaler. Means are provided to generate a flow of composition from the source along the outlet flow path and out of the composition outlet when suction is applied to the outlet end. A pair of air outlets at the outlet end are arranged on opposite sides of the composition outlet through which air is drawn in respective air jets when suction is applied to the outlet end. The composition and air outlets are arranged such that, in use, the pair of air jets impinge on the composition plume.

Abstract: The present invention provides a cannabinoid inhaler, compositions, and methods for delivering a cannabinoid composition to a subject. The cannabinoid composition is delivered in the form of inhaled droplets of respirable size via pulmonary administration. The invention may be used in the treatment of a condition or disorder selected from the group consisting of neuropathic pain, cannabis addiction, nausea, motion sickness, arthritis, and neurodegenerative disease.

Abstract: The present invention relates to processes for deriving components or products from tobacco biomass. In particular the invention relates to a process for deriving two or more components or products from a single tobacco biomass stock, wherein during the process, at least one component or product, for example nicotine, is extracted from a liquid phase and at least one component or product, for example an organic molecule such as an alcohol, is produced from a solid phase. The invention also relates to products, particularly plastics, synthesised from the organic molecules derived from the biomass stock.