Patents by Inventor Alex Herman

Alex Herman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SALT OF 4-[[4-[[4-(2-CYANOETHENYL)-2,6-DIMETHYLPHENYL]AMINO]-2-PYRIMIDINYL]AMINO]BENZONITRILE
    Publication number: 20180116964
    Abstract: The present invention relates to the fumarate salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile, pharmaceutical compositions comprising as active ingredient said salt and to processes for their preparation.
    Type: Application
    Filed: December 22, 2017
    Publication date: May 3, 2018
    Inventors: Paul Theodoor Agnes Stevens, Jozef Peeters, Roger Petrus Gerebern Vandecruys, Alfred Elisabeth Stappers, Alex Herman Copmans
  • 2-((4-AMINO-3-(3-FLUORO-5-HYDROXYPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-1 -YL)METHYL)-3-(2-(TRIFLUORO-MET HYL)BENZYL)QUINAZOLIN-4(3H)-ONE DERIVATIVES AND THEIR USE AS PHOSPHOINOSITIDE 3-KINASE INHIBITORS
    Publication number: 20170334919
    Abstract: The present invention relates inter alia to a compound of formula (I) and to compositions comprising the same and to the use of the compounds and to compositions of the compounds in treatment, for example in the treatment of inflammatory diseases, in particular respiratory inflammatory disease. The invention also extends to methods of making the said compounds.
    Type: Application
    Filed: July 27, 2017
    Publication date: November 23, 2017
    Applicant: RESPIVERT LTD.
    Inventors: Rudy Laurent Maria Broeckx, Alex Herman Copmans, Alun John Smith, David Michel Adrien Taddei, Stuart Thomas Onions
  • 2-((4-amino-3-(3-fluoro-5-hydroxyphenyl)-1H-pyrazolo[3,4-D]pyrimidin-1-yl)methyl)-3-(2-(trifluoromethyl)benzyl) quinazolin-4(3H)-one derivatives and their use as phosphoinositide 3-kinase inhibitors
    Patent number: 9745306
    Abstract: The present invention relates inter alia to a compound of formula (I) and to compositions comprising the same and to the use of the compounds and to compositions of the compounds in treatment, for example in the treatment of inflammatory diseases, in particular respiratory inflammatory disease. The invention also extends to methods of making the said compounds.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: August 29, 2017
    Assignee: Respivert Limited
    Inventors: Rudy Laurent Maria Broeckx, Alex Herman Copmans, Alun John Smith, David Michel Adrien Taddei, Stuart Thomas Onions
  • CRYSTALLINE Pl3 KINASE INHIBITORS
    Publication number: 20170239256
    Abstract: There is provided inter alia 6-(2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl) methyl)-3-(2-chlorobenzyl)-4-oxo-3,4-di hydroquinazolin-5-yl)-N, N-bis(2-methoxyethyl)hex-5-ynamide in the form of a solid crystalline hydrate and in solid crystalline anhydrous form. There are also provided dry powder pharmaceutical compositions for inhalation containing such solid crystalline forms.
    Type: Application
    Filed: May 8, 2017
    Publication date: August 24, 2017
    Applicant: Respivert Limited
    Inventors: Rudy Laurent Maria Broeckx, Walter Ferdinand Maria Filliers, Patrick Hubert, J Nieste, Alex Herman Copmans, Filip Marcel Vanhoutte, Carina Leys
  • Crystalline 6-(2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-D]pyrimidin-1-yl)methyl)-3-(2-chlorobenzyl)-4-0X0-3,4-dihydroquinazolin-5-yl)-N,N-bis(2-methoxyethyl)hex-5-ynamide
    Patent number: 9642799
    Abstract: There is provided inter alia 6-(2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl) methyl)-3-(2-chlorobenzyl)-4-oxo-3,4-dihydroquinazolin-5-yl)-N,N-bis(2-methoxyethyl)hex-5-ynamide in the form of a solid crystalline hydrate and in solid crystalline anhydrous form. There are also provided dry powder pharmaceutical compositions for inhalation containing such solid crystalline forms.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: May 9, 2017
    Assignee: Respivert, Ltd.
    Inventors: Rudy Laurent Maria Broeckx, Walter Ferdinand Maria Filliers, Patrick Hubert J Nieste, Alex Herman Copmans, Filip Marcel Vanhoutte, Carina Leys
  • Phosphoinositide 3-kinase inhibitors
    Patent number: 9556184
    Abstract: The present invention relates inter alia to a compound of formula (I) and to compositions comprising the same and to the use of the compounds and to compositions of the compounds in treatment, for example in the treatment of inflammatory diseases, in particular respiratory inflammatory disease. The invention also extends to methods of making the said compounds.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: January 31, 2017
    Assignee: Respivert, Ltd.
    Inventors: David Michel Adrien Taddei, Stuart Thomas Onions, Alun John Smith, Alex Herman Copmans, Rudy Laurent Maria Broeckx
  • Phosphoinositide 3-Kinase Inhibitors
    Publication number: 20160090389
    Abstract: The present invention relates inter alia to a compound of formula (I) and to compositions comprising the same and to the use of the compounds and to compositions of the compounds in treatment, for example in the treatment of inflammatory diseases, in particular respiratory inflammatory disease. The invention also extends to methods of making the said compounds.
    Type: Application
    Filed: December 4, 2015
    Publication date: March 31, 2016
    Applicant: Respivert Ltd.
    Inventors: David Michel Adrien Taddei, Stuart Thomas Onions, Alun John Smith, Alex Herman Copmans, Rudy Laurent Maria Broeckx
  • 2-((4-AMINO-3-(3-FLUORO-5-HYDROXYPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-1 -YL)METHYL)-3-(2-(TRIFLUOROMETHYL)BENZYL) QUINAZOLIN-4(3H)-ONE DERIVATIVES AND THEIR USE AS PHOSPHOINOSITIDE 3-KINASE INHIBITORS
    Publication number: 20160039826
    Abstract: The present invention relates inter alia to a compound of formula (I) and to compositions comprising the same and to the use of the compounds and to compositions of the compounds in treatment, for example in the treatment of inflammatory diseases, in particular respiratory inflammatory disease. The invention also extends to methods of making the said compounds.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 11, 2016
    Inventors: Rudy Laurent Maria Broeckx, Alex Herman Copmans, Alun John Smith, David Michel Adrien Taddei, Stuart Thomas Onions
  • Phosphoinositide 3-kinase inhibitors
    Patent number: 9227977
    Abstract: The present invention relates inter alia to a compound of formula (I) and to compositions comprising the same and to the use of the compounds and to compositions of the compounds in treatment, for example in the treatment of inflammatory diseases, in particular respiratory inflammatory disease. The invention also extends to methods of making the said compounds.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: January 5, 2016
    Assignee: Respivert Ltd.
    Inventors: David Michel Adrien Taddei, Stuart Thomas Onions, Alun John Smith, Alex Herman Copmans, Rudy Laurent Maria Broeckx
  • CRYSTALLINE Pl3 KINASE INHIBITORS
    Publication number: 20150105408
    Abstract: There is provided inter alia 6-(2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-3-(2-chlorobenzyl)-4-oxo-3,4-dihydroquinazolin-5-yl)-N,N-bis(2-methoxyethyl)hex-5-ynamide in the form of a solid crystalline hydrate and in solid crystalline anhydrous form. There are also provided dry powder pharmaceutical compositions for inhalation containing such solid crystalline forms.
    Type: Application
    Filed: March 13, 2013
    Publication date: April 16, 2015
    Inventors: Rudy Laurent Maria Broeckx, Walter Ferdinand Maria Filliers, Patrick Hubert, J Nieste, Alex Herman Copmans, Filip Marcel Vanhoutte, Carina Leys
  • NOVEL PHARMACEUTICAL FORMULATIONS
    Publication number: 20150099768
    Abstract: There is provided inter alia a dry powder pharmaceutical formulation for inhalation comprising: (i) 6-(2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl) methyl)-3-(2-chlorobenzyl)-4-oxo-3,4-dihydroquinazolin-5-yl)-N,N-bis(2-methoxyethyl)hex-5-ynamide or a pharmaceutically acceptable salt thereof, including all stereoisomers, tautomers and isotopic derivatives thereof and solvates thereof in particulate form as active ingredient; (ii) particulate lactose as carrier; and (iii) a particulate stabilizing agent selected from metal salts of stearic acid such as magnesium stearate and metal salts of stearyl fumarate.
    Type: Application
    Filed: March 13, 2013
    Publication date: April 9, 2015
    Inventors: Rudy Laurent Maria Broeckx, Walter Ferdinand Maria Filliers, Patrick Hubert J. Nieste, Alex Herman Copmans, Filip Marcel C. Vanhoutte, Carina Leys
  • COMPOUND
    Publication number: 20140274980
    Abstract: The present invention relates inter alia to a compound of formula (I) and to compositions comprising the same and to the use of the compounds and to compositions of the compounds in treatment, for example in the treatment of inflammatory diseases, in particular respiratory inflammatory disease. The invention also extends to methods of making the said compounds.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicant: RESPIVERT LTD.
    Inventors: David Michel Adrien Taddei, Stuart Thomas Onions, Alun John Smith, Alex Herman Copmans, Rudy Laurent Maria Broeckx
  • Resolution of (±)-methyl phenyl[4-[4-[[[4?(trifluoromethyl)-2-biphenylyl]carbonyl]amino]Phenyl]-1-piperidinyl]acetate
    Patent number: 8461341
    Abstract: The present invention relates to a resolution process of (±)-methyl phenyl[4-[4-[[[4?-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate to isolate the MTP (microsomal triglyceride transfer protein) inhibitor methyl (2S)-phenyl[4-[4-[[[4?-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate and an epimerisation procedure for racemizing methyl (2R)-phenyl[4-[4-[[[4?-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate.
    Type: Grant
    Filed: May 27, 2010
    Date of Patent: June 11, 2013
    Assignee: Janssen Pharmaceutica NV
    Inventors: Alex Herman Copmans, Jérôme Albert Joseph Hoet, Albert Louis Anna Willemsens, Wouter Louis J Couck, Joannes Petrus Van Dun
  • RESOLUTION OF (±)-METHYL PHENYL[4-[4-[[[4'(TRIFLUOROMETHYL)-2- BIPHENYLYL]CARBONYL]AMINO]PHENYL]-1-PIPERIDINYL]ACETATE
    Publication number: 20120071660
    Abstract: The present invention relates to a resolution process of (±)-methyl phenyl[4-[4-[[[4?-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate to isolate the MTP (microsomal triglyceride transfer protein) inhibitor methyl (2S)-phenyl[4-[4-[[[4?-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate and an epimerisation procedure for racemizing methyl (2R)-phenyl[4-[4-[[[4?-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate.
    Type: Application
    Filed: May 27, 2010
    Publication date: March 22, 2012
    Inventors: Alex Herman Copmans, Jérôme Albert Joseph Hoet, Albert Louis Anna Willemsems, Wouter Louis J. Couck, Joaanes Petrus Van Dun
  • Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
    Patent number: 8101629
    Abstract: The present invention relates to a pharmaceutical composition comprising as active ingredient the hydrochloric acid salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethyl-phenyl]amino]-2-pyrimidinyl]amino]benzonitrile and to processes for their preparation.
    Type: Grant
    Filed: July 28, 2010
    Date of Patent: January 24, 2012
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jérôme Emile Georges Guillemont, Paul Theodoor Agnes Stevens, Alex Herman Copmans, Jozef Peeters, Alfred Elisabeth Stappers, Roger Petrus Gerebern Vandecruys, Paul Stoffels
  • SALT OF 4-[[4-[[4-(2-CYANOETHENYL)-2,6-DIMETHYLPHENYL]AMINO] -2-PYRIMIDINYL]AMINO]BENZONITRILE
    Publication number: 20110150996
    Abstract: The present invention relates to the fumarate salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile, pharmaceutical compositions comprising as active ingredient said salt and to processes for their preparation.
    Type: Application
    Filed: March 4, 2011
    Publication date: June 23, 2011
    Inventors: Paul Theodoor Agnes Stevens, Jozef Peeters, Roger Petrus Gerebem Vandecruys, Alfred Elisabeth Stappers, Alex Herman Copmans
  • Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
    Patent number: 7956063
    Abstract: The present invention relates to a pharmaceutical composition comprising as active ingredient the hydrochloric acid salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethyl-phenyl]amino]-2-pyrimidinyl]amino]benzonitrile and to processes for their preparation.
    Type: Grant
    Filed: July 7, 2008
    Date of Patent: June 7, 2011
    Assignee: Janssen Pharmaceutica NV
    Inventors: Jérôme Emile Georges Guillemont, Paul Theodoor Agnes Stevens, Alex Herman Copmans, Jozef Peeters, Alfred Elisabeth Stappers, Roger Petrus Gerebern Vandecruys, Paul Stoffels
  • SALT OF 4-[[4-[[4-(2-CYANOETHENYL)-2,6-DIMETHYLPHENYL]AMINO]-2-PYRIMIDINYL]AMINO]BENZONITRILE
    Publication number: 20110008434
    Abstract: The present invention relates to a pharmaceutical composition comprising as active ingredient the hydrochloric acid salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethyl-phenyl]amino]-2-pyrimidinyl]amino]benzonitrile and to processes for their preparation.
    Type: Application
    Filed: July 28, 2010
    Publication date: January 13, 2011
    Inventors: Jérôme Emile Georges GUILLEMONT, Paul Theodoor Agnes Stevens, Alex Herman Copmans, Jozef Peeters, Alfred Elisabeth Stappers, Roger Petrus Gerebern Vandecruys, Paul Stoffels
  • Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino] benzonitrile
    Patent number: 7638522
    Abstract: The present invention relates to a pharmaceutical composition comprising as active ingredient the hydrochloric acid salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethyl-phenyl]amino]-2-pyrimidinyl]amino]benzonitrile and to processes for their preparation.
    Type: Grant
    Filed: September 2, 2005
    Date of Patent: December 29, 2009
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jérôme Emile Georges Guillemont, Paul Theodoor Agnes Stevens, Alex Herman Copmans, Jozef Peeters, Alfred Elisabeth Stappers, Roger Petrus Gerebern Vandecruys, Paul Stoffels
  • FUMARATE OF 4- [[4- [[4- (2-CYANOETHENYL) -2,6-DIMETHYLPHENYL)AMINO] -2-PYRIMIDINYL]AMINO]BENZONITRILE
    Publication number: 20090215804
    Abstract: The present invention relates to the fumarate salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile, pharmaceutical compositions comprising as active ingredient said salt and to processes for their preparation.
    Type: Application
    Filed: September 2, 2005
    Publication date: August 27, 2009
    Inventors: Paul Theodoor Agnes Stevens, Jozef Peeters, Roger Petrus Gerebern Vandecruys, Alfred Elisabeth Stappers, Alex Herman Copmans