Patents by Inventor Alex Karpeisky

Alex Karpeisky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Non-nucleotide containing RNA
    Patent number: 6849726
    Abstract: The present invention relates to RNA molecules containing one or more non-nucleotide mimetics.
    Type: Grant
    Filed: March 17, 2003
    Date of Patent: February 1, 2005
    Assignee: Sirna Therapeutics, Inc.
    Inventors: Nassim Usman, Francine Wincott, Jasenka Matulic-Adamic, Leonid Beigelman, Alex Karpeisky
  • 2?-O-alkylthioalkyl and 2?-C-alkylthioalkyl-containing nucleic acids
    Patent number: 6818759
    Abstract: A compound having the formula: wherein, R1 represents 2′-O-alkylthioalkyl or 2′-C-alkylthioalkyl; X represents a base or H; Y represents a phosphorus-containing group; and R2 represents H, DMT or a phosphorus-containing group.
    Type: Grant
    Filed: June 19, 2002
    Date of Patent: November 16, 2004
    Assignee: Sirna Therapeutics, Inc.
    Inventors: Leonid Beigelman, Alex Karpeisky
  • Base-modified enzymatic nucleic acid
    Publication number: 20030166896
    Abstract: Method to produce a more active ribozyme by introducing a modified base into a substrate binding arm of the ribozyme or its catalytic core.
    Type: Application
    Filed: June 13, 2002
    Publication date: September 4, 2003
    Applicant: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, Leonid Beigelman, James McSwiggen, Alex Karpeisky
  • 2'-O-alkylthioalkyl and 2'-C-alkylthioalkyl-containing nucleic acids
    Publication number: 20030165900
    Abstract: A compound having the formula: 1
    Type: Application
    Filed: June 19, 2002
    Publication date: September 4, 2003
    Applicant: Ribozyme Pharmaceuticals, Inc.
    Inventors: Leonid Beigelman, Alex Karpeisky
  • Non-nucleotide containing enzymatic nucleic acid
    Patent number: 6555668
    Abstract: Enzymatic nucleic acid molecule containing one or more non-nucleotide mimetics, and having activity to cleave an RNA or DNA molecule.
    Type: Grant
    Filed: January 8, 2002
    Date of Patent: April 29, 2003
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, Francine Wincott, Jasenka Matulic-Adamic, Leonid Beigelman, Alex Karpeisky
  • Base-modified enzymatic nucleic acid
    Patent number: 6528639
    Abstract: Method to produce a more active ribozyme by introducing a modified base into a substrate binding arm of the ribozyme or its catalytic core.
    Type: Grant
    Filed: March 3, 1998
    Date of Patent: March 4, 2003
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, Leonid Beigelman, James McSwiggen, Alex Karpeisky
  • Non-nucleotide containing enzymatic nucleic acid
    Publication number: 20020193579
    Abstract: Enzymatic nucleic acid molecule containing one or more non-nucleotide mimetics, and having activity to cleave an RNA or DNA molecule.
    Type: Application
    Filed: January 8, 2002
    Publication date: December 19, 2002
    Applicant: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, Francine Wincott, Jasenka Matulic-Adamic, Leonid Beigelman, Alex Karpeisky
  • 2?-O-alkylthioalkyl and 2?-C-alkythioalkyl containing nucleic acids
    Patent number: 6451540
    Abstract: A compound having the formula: wherein, R1 represents 2′-O-alkylthioalkyl or 2′-C-alkylthioalkyl; X represents a base or H; Y represents a phosphorus-containing group; and R2 represents H, DMT or a phosphorus-containing group.
    Type: Grant
    Filed: March 13, 2001
    Date of Patent: September 17, 2002
    Assignee: Ribozyme Pharmaceuticals, Incorporated
    Inventors: Leonid Beigelman, Alex Karpeisky
  • Compositions for the delivery of negatively charged molecules
    Patent number: 6395713
    Abstract: This invention features permeability enhancer molecules, and methods, to increase membrane permeability of negatively charged polymers thereby facilitating cellular uptake of such polymers.
    Type: Grant
    Filed: July 21, 1998
    Date of Patent: May 28, 2002
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Leonid Beigelman, Jasenka Matulic-Adamic, Alex Karpeisky, Peter Haeberli, David Sweedler, Mark Reynolds, Nilabh Chaudhary, John Min
  • Non-nucleotide containing nucleic acid
    Patent number: 6362323
    Abstract: Enzymatic nucleic acid molecule containing one or more non-nucleotide mimetics, and having activity to cleave an RNA or DNA molecule.
    Type: Grant
    Filed: July 31, 2000
    Date of Patent: March 26, 2002
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, Francine Wincott, Jasenka Matulic-Adamic, Leonid Beigelman, Alex Karpeisky
  • 2'-O-alkylthioalkyl and 2'-C-alkythioalkyl containing nucleic acids
    Publication number: 20010012618
    Abstract: A compound having the formula: 1
    Type: Application
    Filed: March 13, 2001
    Publication date: August 9, 2001
    Inventors: Leonid Beigelman, Alex Karpeisky
  • BASE-MODIFIED ENZYMATIC NUCLEIC ACID
    Publication number: 20010006801
    Abstract: Method to produce a more active ribozyme by introducing a modified base into a substrate binding arm of the ribozyme or its catalytic core.
    Type: Application
    Filed: March 3, 1998
    Publication date: July 5, 2001
    Inventors: NASSIM USMAN, LEONID BEIGELMAN, JAMES MCSWIGGEN, ALEX KARPEISKY
  • 2'-O-alkylthioalkyl and 2'-c-alkylthioalkyl-containing nucleic acids
    Patent number: 6239272
    Abstract: A compound having the formula: wherein, R1 represents 2′-O-R3-thio-R3 and/or 2′-C-R3-thio-R3, wherein R3 is a compound independently selected from a group consisting of alkyl, alkenyl, alkynyl, aryl, alkylaryl, carbocyclic aryl, heterocyclic aryl, amide and ester, X represents a base or H; Y represents a phosphorus-containing group; and R2 represents H, DMT or a phosphorus-containing group.
    Type: Grant
    Filed: June 17, 1998
    Date of Patent: May 29, 2001
    Assignee: Ribozyme Pharmaceutical
    Inventors: Leonid Beigelman, Alex Karpeisky
  • Non-nucleotide containing enzymatic nucleic acid
    Patent number: 6117657
    Abstract: Enzymatic nucleic acid molecule containing one or more non-nucleotide mimetics, and having activity to cleave an RNA or DNA molecule.
    Type: Grant
    Filed: October 29, 1998
    Date of Patent: September 12, 2000
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, Francine Wincott, Jasenka Matulic-Adamic, Leonid Beigelman, Alex Karpeisky
  • Non-nucleotide containing enzymatic nucleic acid
    Patent number: 5891683
    Abstract: Enzymatic nucleic acid molecule containing one or more non-nucleotide mimetics, and having activity to cleave an RNA or DNA molecule.
    Type: Grant
    Filed: December 23, 1994
    Date of Patent: April 6, 1999
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, Francine Wincott, Jasenka Matulic-Adamic, Leonid Beigelman, Alex Karpeisky
  • Base-modified enzymatic nucleic acid
    Patent number: 5891684
    Abstract: Method to produce a more active ribozyme by introducing a modified base into a substrate binding arm of the ribozyme or its catalytic core.
    Type: Grant
    Filed: December 23, 1994
    Date of Patent: April 6, 1999
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, Leonid Beigelman, James McSwiggen, Alex Karpeisky
  • Base-modified enzymatic nucleic acid
    Patent number: 5879938
    Abstract: Method to produce a more active ribozyme by introducing a modified base into a substrate binding arm of the ribozyme or its catalytic core.
    Type: Grant
    Filed: May 5, 1995
    Date of Patent: March 9, 1999
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, Leonid Beigelman, James McSwiggen, Alex Karpeisky
  • 2'-O-alkylthioalkyl and 2'-C-alkylthioalkyl-containing nucleic acids
    Patent number: 5840876
    Abstract: A compound having the formula: ##STR1## wherein, R1 represents 2'-O-R.sub.3 -thio-R.sub.3 and/or 2'-C-R.sub.3 -thio-R.sub.3, wherein R.sub.3 is independently a compound selected from a group consisting of alkyl, alkenyl, alkynyl, aryl, alkylaryl, carbocyclic aryl, heterocyclic aryl, amide and ester; X represents a base or H; Y represents a phosphorus-containing group; and R2 represents H, DMT or a phosphorus-containing group.
    Type: Grant
    Filed: June 12, 1997
    Date of Patent: November 24, 1998
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Leonid Beigelman, Alex Karpeisky
  • Base-modified enzymatic nucleic acid
    Patent number: 5767263
    Abstract: Method to produce a more active ribozyme by introducing a modified base into a substrate binding arm of the ribozyme or its catalytic core.
    Type: Grant
    Filed: May 5, 1995
    Date of Patent: June 16, 1998
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, Leonid Beigelman, James McSwiggen, Alex Karpeisky
  • 2'-O-alkylthioalkyl and 2-C-alkylthioalkyl-containing enzymatic nucleic acids (ribozymes)
    Patent number: 5716824
    Abstract: A compound having the formula: ##STR1## wherein, R1 represents 2'-O-R.sub.3 -thio-R.sub.3 and/or 2'-C-R.sub.3 -thio-R.sub.3, wherein R.sub.3 is independently a moiety selected from a group consisting of alkyl, alkenyl, alkynyl, aryl, alkylaryl, carbocyclic aryl, heterocyclic aryl, amide and ester, X represents a base or H; Y represents a phosphorus-containing group; and R2 represents H, DMT or a phosphorus-containing group.
    Type: Grant
    Filed: April 20, 1995
    Date of Patent: February 10, 1998
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Leonid Beigelman, Alex Karpeisky