Patents by Inventor Alex Kharazi

Alex Kharazi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160287638
    Abstract: A method for treatment of peripheral arterial disease conditions comprising systemically administering an effective amount of therapeutic stem cells. Included within the scope of the invention is intravenous administration of a therapeutic amount of ischemic tolerant mesenchymal stem cells in the treatment of peripheral arterial disease.
    Type: Application
    Filed: April 2, 2015
    Publication date: October 6, 2016
    Applicant: Stemedica Cell Technologies, Inc.
    Inventors: Stephen E. Epstein, Alex Kharazi, Nikolai Tankovich, Sergey Sikora
  • Patent number: 9080184
    Abstract: The invention relates to transgenic stem cells for therapeutic use. Stem cells according to the invention comprise at least one therapeutic trans gene that is expressed when transplanted to a subject. Methods of use and manufacturing the transgenic stem cells of the invention are also contemplated, including the use of transiently transgenic G-CSF bone marrow stem cells for treating the penumbra of ischemic tissues such as central nervous system tissues.
    Type: Grant
    Filed: February 25, 2013
    Date of Patent: July 14, 2015
    Assignee: Stemedica Cell Technologies, Inc.
    Inventors: Alex Kharazi, M G Muralidhar, Grigory Vertelov
  • Publication number: 20140242047
    Abstract: The invention relates to transgenic stem cells for therapeutic use. Stem cells according to the invention comprise at least one therapeutic trans gene that is expressed when transplanted to a subject. Methods of use and manufacturing the transgenic stem cells of the invention are also contemplated, including the use of transiently transgenic G-CSF bone marrow stem cells for treating the penumbra of ischemic tissues such as central nervous system tissues.
    Type: Application
    Filed: February 25, 2013
    Publication date: August 28, 2014
    Inventors: ALEX KHARAZI, MG MURALIDHAR, GRIGORY VERELOV
  • Patent number: 7674456
    Abstract: The invention provides, in part, novel SV-BR cancer cell lines. The invention provides a novel cell line SV-BR-1 deposited under ATCC PTA-1712 and SV-BR-1-GM cells deposited under ATCC PTA-1713. The invention further relates to therapeutic and non-therapeutic uses of the novel cell lines. Therapeutic uses include the use of SV-BR cell lines as cancer vaccines, and in particular, or the treatment of cancer.
    Type: Grant
    Filed: June 14, 2004
    Date of Patent: March 9, 2010
    Inventors: Charles Wiseman, Alex Kharazi
  • Publication number: 20080247263
    Abstract: Compounding or extrusion rates can be increased by splitting the polymer solid feed. Melting of additional solid polymer is significantly assisted by excess enthalpy from incoming melt from a primary mixing stage. Depending on resin rheology and melting characteristics, rate increases were achieved of from up to about 55 to about 100% rate increase over the use of a single feed at the same rotor speed. The net result is a decrease in the overall SEI (specific energy input to the polymer) and thus melt temperatures.
    Type: Application
    Filed: August 2, 2006
    Publication date: October 9, 2008
    Inventors: Mohamed Esseghir, Alex Kharazi, Anthony C. Neubauer, Albert A. Quaranta
  • Publication number: 20050276822
    Abstract: The invention provides, in part, novel SV-BR cancer cell lines. The invention provides a novel cell line SV-BR-1 deposited under ATCC ______, and SV-BR-1-GM cells deposited under ATCC ______. The invention further relates to therapeutic and non-therapeutic uses of the novel cell lines. Therapeutic uses include the use of SV-BR cell lines as cancer vaccines, and in particular, or the treatment of cancer.
    Type: Application
    Filed: June 14, 2004
    Publication date: December 15, 2005
    Inventors: Charles Wiseman, Alex Kharazi
  • Patent number: 6565779
    Abstract: A process for the preparation of a semiconducting shield composition comprising: (i) introducing an elastomer into a melt/mixer having a melting zone and a mixing zone; (ii) introducing particulate conductive carbon black into the melt/mixer in an amount of about 10 to about 25 percent by weight based on the weight of the resin; (iii) melting the elastomer in the melting zone; (iv) mixing the carbon black and the molten elastomer in the mixing zone; (v) optionally, pelletizing the mixture of carbon black and elastomer; (vi) recycling the mixture of carbon black and elastomer from step (iv) or the pellets from step (v) to a melt/mixer; (vii) introducing additional particulate semiconductive carbon black into the melt/mixer in an amount sufficient to provide a total amount of carbon black in the range of about 25 to about 50 percent by weight based on the weight of the resin; (viii) melting and mixing the mixture from step (vii); and (ix) pelletizing or extruding the mixture from step (viii).
    Type: Grant
    Filed: March 31, 1998
    Date of Patent: May 20, 2003
    Assignee: Union Carbide Chemicals & Plastics Technology Corporation
    Inventor: Alex Kharazi
  • Patent number: 6565784
    Abstract: A process for the preparation of a composition useful in telecommunications jacketing comprising: (i) introducing a polyolefin into the first mixing zone of a melt/mixer having first and second mixing zones; (ii) introducing particulate carbon black per se or a premix of said carbon black and polyolefin into the first mixing zone, said carbon black being in an amount of about 2 to about 50 percent based on the weight of the polyolefin introduced into the first mixing zone; (iii) melting the polyolefin in the presence of the carbon black in the first mixing zone; (iv) mixing the carbon black and the molten polyolefin in the first mixing zone to provide a molten mixture; (v) passing the molten mixture from step (iv) into the second mixing zone; (vi) adding sufficient polyolefin to the molten mixture from step (v) to dilute the carbon black to a level of about 2 to about 3 percent by weight based on the weight of the total polyolefin in the melt/mixer; (vii) mixing the added polyolefin with the molten mix
    Type: Grant
    Filed: June 1, 2000
    Date of Patent: May 20, 2003
    Assignee: Union Carbide Chemicals & Plastics Technology Corporation
    Inventors: Mohamed Esseghir, Alex Kharazi, John Francis Wojdyla, Sean Gerard Duffy, Thomas Shiaw-Tong Lin
  • Patent number: 6426026
    Abstract: Disclosed is a process for pelletizing high melt flow crystalline polymers to produce crystalline pellet products. The process includes feeding a polyolefin granular or pelleted polymer into a melting/mixing mechanism to provide a molten polymer material. The molten polymer material is optionally passed through a melt pump and through a die to form a plurality of molten polymer strands. The plurality of molten polymer strands then are passed through or along a water trough declined with respect to the direction of the horizontal arrays where they are sprayed with cool liquid a plurality of times in such a manner that the sprayed cool liquid creates turbulent flow and disturbs a thin film of hot water and/or steam that forms around each molten polymer strand as it is cooled without undesirable axial acceleration of the polymer strands. Subjecting the molten polymer strands to such a cooling procedure produces cooled polymer strands, which then are fed to a cutting mechanism and cut into pellets.
    Type: Grant
    Filed: December 28, 1999
    Date of Patent: July 30, 2002
    Assignee: Union Carbide Chemicals & Plastics Technology Corporation
    Inventors: Marios Avgousti, Edward Allen Leach, Alex Kharazi
  • Patent number: 6359077
    Abstract: Disclosed is a process making polyolefin pellet products that contain at least one unreacted free radical generator which, when heated, undergo chemical degradation producing a low viscosity polymer. The process includes contacting the polyolefin pellet with the at least one free radical generator to coat the pellet, and contacting the coated pellets and at least one unreacted free radical generator at an elevated temperature and for a period of time sufficient for the free radical initiator to soak into the interior of the pellets. The process of the invention enables the production of polyolefin pellets having any desired amount of free radical generator and therefore, production of a desired viscosity, and improves the processability of the polyolefin pellet at customer fabrication facilities to thereby provide superior quality final articles.
    Type: Grant
    Filed: March 29, 2000
    Date of Patent: March 19, 2002
    Assignee: Union Carbide Chemicals & Plastics Technology Corporation
    Inventors: Marios Avgousti, Alex Kharazi
  • Patent number: 5972267
    Abstract: A process comprising the following steps: (a) maintaining the process in an essentially oxygen-free state; (b) introducing a first polymer directly from the polymerization reactor in which it was prepared, in molten form, into a mixer/compounder; (c) reducing any higher pressure accompanying the first polymer from the polymerization reactor to the mixer/compounder to a pressure in the range of about 0 to about 5 barg; (d) adding additives selected from the group consisting of antioxidants, second polymers, other polymer enhancing additives, and mixtures thereof to the mixer/compounder, and mixing same with the molten first polymer; (e) passing the molten mixture from step (d) through one or more screens, each having a maximum opening size of about 25 microns; (f) pelletizing the mixture from step (e); (g) introducing the pellets into a spraying chamber, the interior of said chamber being operated in a static condition; (h) spraying the pellets in the chamber with a crosslinking formulation including an organi
    Type: Grant
    Filed: March 30, 1998
    Date of Patent: October 26, 1999
    Assignee: Union Carbide Chemicals & Plastics Technology Corporation
    Inventors: Alex Kharazi, Neil William Dunchus