Abstract: A locking catheter system includes a locking mechanism. The locking mechanism includes a lock body having a system lumen extending through the lock body, wherein first and second catheters are received in the system lumen. A system channel extends from the system lumen, and the system channel is configured to receive one or more of the first or second catheters. A locking channel having a lock element extends from the system lumen. The locking channel is configured to receive one or more of the first or second catheters. In an unlocked configuration the first and second catheters are received in the system channel and are movable relative to the lock body. In the locked configuration at least the second catheter is received in the locking channel, the second catheter is statically coupled with the lock body, and the first catheter is movable relative to the lock body.

Abstract: An over-the-wire retrieval system having at least one expandable filter basket deployable and retrievable over a positioning guidewire that remains in place throughout the thrombectomy procedure. The filter catheter can slidably receive the positioning guidewire allowing the positioning guidewire to navigate a collapsed filter basket past a clot before the filter basket is expanded and pulled through the clot to engage or capture clot material. The filter basket can be re-collapsed and navigated past the clot over the positioning guidewire for multiple passes through the clot. The filter catheter can be paired with a flexible capture sleeve or an aspiration sheath for collection and removal of the clot material gathered by the filter basket on each pass. The flexible capture sleeve includes, in an example, a thrombus conveyor configured to transition between everted and inverted configurations.