Patents by Inventor Alex Mark Prokai

Alex Mark Prokai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polypeptide compositions with improved stability
    Patent number: 7022674
    Abstract: The present invention provides means to improve the chemical stability of aqueous, parenteral pharmaceutical compositions comprising a polypeptide and glycerin. Reactive aldehydes are identified in commercial glycerins, and means for reducing such are provided. Convenient means are provided to assay for reactive aldehydes in glycerin, and a strong linear correlation between the level of reactive aldehydes in glycerin and chemical stability of compositions comprising a polypeptide and glycerin is demonstrated. The invention includes aqueous compositions comprising a polypeptide and glycerin having improved chemical stability compared to compositions previously known.
    Type: Grant
    Filed: December 5, 2000
    Date of Patent: April 4, 2006
    Assignee: Eli Lilly and Company
    Inventors: Michael Rosario DeFelippis, Michael Allen Dobbins, Alby David Sharknas, Alex Mark Prokai, Joseph Vincent Rinella
  • Polypeptide compositions with improved stability
    Publication number: 20030207802
    Abstract: The present invention provides means to improve the chemical stability of aqueous, parenteral pharmaceutical compositions comprising a polypeptide and glycerin. Reactive aldehydes are identified in commercial glycerins, and means for reducing such are provided. Convenient means are provided to assay for reactive aldehydes in glycerin, and a strong linear correlation between the level of reactive aldehydes in glycerin and chemical stability of compositions comprising a polypeptide and glycerin is demonstrated. The invention includes aqueous compositions comprising a polypeptide and glycerin having improved chemical stability compared to compositions previously known.
    Type: Application
    Filed: May 21, 2002
    Publication date: November 6, 2003
    Inventors: Michael Rosario DeFelippis, Michael Allen Dobbins, Alby David Sharknas, Alex Mark Prokai, Joseph Vincent Rinella