Patents by Inventor Alex Muci

Alex Muci has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Certain chemical entities, compositions and methods
    Patent number: 8293761
    Abstract: Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of obesity, sarcopenia, wasting syndrome, frailty, cachexia, muscle spasm, post-surgical and post-traumatic muscle weakness, neuromuscular disease, and other indications.
    Type: Grant
    Filed: April 22, 2010
    Date of Patent: October 23, 2012
    Assignee: Cytokinetics, Inc.
    Inventors: Alex Muci, Jeffrey T. Finer, Pu-Ping Lu, Alan James Russell, Bradley P. Morgan, David J. Morgans, Jr.
  • Ureas and Their Use in the Treatment of Heart Failure
    Publication number: 20120172372
    Abstract: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
    Type: Application
    Filed: December 30, 2011
    Publication date: July 5, 2012
    Inventors: Bradley Paul Morgan, Alex Muci, Pu-Ping Lu, Erica Anne Kraynack, Todd Tochimoto, David J. Morgans, JR.
  • Ureas and their use in the treatment of heart failure
    Patent number: 8110595
    Abstract: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
    Type: Grant
    Filed: June 16, 2005
    Date of Patent: February 7, 2012
    Assignee: Cytokinetics, Inc.
    Inventors: Bradley Paul Morgan, Alex Muci, Pu-Ping Lu, Erica Anne Kraynack, Todd Tochimoto, David J. Morgans, Jr.
  • Disubstituted ureas and uses thereof in treating heart failure
    Patent number: 8101617
    Abstract: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
    Type: Grant
    Filed: September 25, 2008
    Date of Patent: January 24, 2012
    Assignee: Amgen, Inc.
    Inventors: Bradley Paul Morgan, Alex Muci, Pu-Ping Lu, Erica Anne Kraynack, Todd Tochimoto, David J. Morgans, Jr.
  • Compounds, compositions and methods
    Patent number: 7989455
    Abstract: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
    Type: Grant
    Filed: December 14, 2006
    Date of Patent: August 2, 2011
    Assignee: Cytokinetics, Inc.
    Inventors: Bradley P. Morgan, David J. Morgans, Jr., Alex Muci, Pu-Ping Lu, Erica A. Kraynack, Todd Tochimoto
  • Certain 1H-imidazo[4,5-B]pyrazin-2(3H)-ones and 1H-imidazo[4,5-B]pyrazin-2-ols, compositions thereof, and methods for their use
    Patent number: 7956056
    Abstract: Provided is at least one chemical entity chosen from compounds of Formula I and Formula II: and pharmaceutically acceptable salts thereof, compositions thereof, and methods for their use in modulating one or more of skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, skeletal muscle, and skeletal sarcomere.
    Type: Grant
    Filed: October 5, 2009
    Date of Patent: June 7, 2011
    Assignee: Cytokinetics, Inc.
    Inventors: Alex Muci, Jeffrey T. Finer, Pu-Ping Lu, Alan James Russell, Bradley P. Morgan, David J. Morgans, Jr.
  • Compounds, compositions and methods
    Patent number: 7910743
    Abstract: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
    Type: Grant
    Filed: May 20, 2009
    Date of Patent: March 22, 2011
    Assignee: Cytokinetics, Inc.
    Inventors: Bradley P. Morgan, Alex Muci, Erica Kraynack, Pu-Ping Lu, Todd Tochimoto, David J. Morgans, Jr.
  • Certain chemical entities, compositions, and methods
    Patent number: 7851484
    Abstract: Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of muscle weakness and/or cachexia, as part of a rehabilitation or conditioning exercise regimen, or in the treatment of fraility, post-polio syndrome, obesity, sarcopenia, wasting syndrome, muscle spasm, and other indications.
    Type: Grant
    Filed: March 28, 2008
    Date of Patent: December 14, 2010
    Assignee: Cytokinetics, Inc.
    Inventors: Bradley P. Morgan, David J. Morgans, Jr., Gustave Bergnes, Alex Muci, Scott Collibee, Pu-Ping Lu, Luke W. Ashcraft, William F. Browne, IV, Marc Andrew Garard
  • Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas
    Patent number: 7825120
    Abstract: Certain substituted ((piperazin-1-ylmethyl)benzyl)urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and may be useful in the treatment of systolic heart failure including congestive heart failure.
    Type: Grant
    Filed: December 13, 2006
    Date of Patent: November 2, 2010
    Assignee: Cytokinetics, Inc.
    Inventors: Bradley P. Morgan, Alex Muci, Erica A. Kraynack, Todd Tochimoto, Pu-Ping Lu, David J. Morgans, Jr.
  • Certain Chemical Entities, Compositions and Methods
    Publication number: 20100210645
    Abstract: Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of obesity, sarcopenia, wasting syndrome, frailty, cachexia, muscle spasm, post-surgical and post-traumatic muscle weakness, neuromuscular disease, and other indications.
    Type: Application
    Filed: April 22, 2010
    Publication date: August 19, 2010
    Inventors: Alex Muci, Jeffrey T. Finer, Pu-Ping Lu, Alan James Russell, Bradley P. Morgan, David J. Morgans, JR.
  • Certain Chemical Entities, Compositions and Methods
    Publication number: 20100210634
    Abstract: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
    Type: Application
    Filed: May 3, 2010
    Publication date: August 19, 2010
    Inventors: Bradley P. Morgan, Erica A. Kraynack, Pu-Ping Lu, Alex Muci, David J. Morgans, JR.
  • Certain Chemical Entities, Compositions and Methods
    Publication number: 20100173930
    Abstract: Provided are certain chemical entities, and methods of use to modulate diskeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of obesity, sarcopenia, wasting syndrome, frailty, muscle spasm, neuromuscular disease, and other indications.
    Type: Application
    Filed: July 31, 2007
    Publication date: July 8, 2010
    Inventors: Alex Muci, Jeffrey T. Finer, Bradley P. Morgan, Alan James Russell, David J. Morgans, JR.
  • Certain indanyl urea modulators of the cardiac sarcomere
    Patent number: 7718657
    Abstract: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
    Type: Grant
    Filed: December 13, 2006
    Date of Patent: May 18, 2010
    Assignee: Cytokinetics, Inc.
    Inventors: Bradley P. Morgan, Erica A. Kraynack, Pu-Ping Lu, Alex Muci, David J. Morgans, Jr.
  • CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS
    Publication number: 20100093741
    Abstract: Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of obesity, sarcopenia, wasting syndrome, frailty, cachexia, muscle spasm, post-surgical and post-traumatic muscle weakness, neuromuscular disease, and other indications.
    Type: Application
    Filed: October 5, 2009
    Publication date: April 15, 2010
    Inventors: Alex Muci, Jeffrey T. Finer, Pu-Ping Lu, Alan James Russell, Bradley P. Morgan, David J. Morgans, JR.
  • Certain Chemical Entities, Compositions and Methods
    Publication number: 20100029680
    Abstract: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
    Type: Application
    Filed: June 11, 2009
    Publication date: February 4, 2010
    Inventors: Bradley P. Morgan, David J. Morgans, JR., Alex Muci, Pu-Ping Lu, Erica A. Kraynack, Todd Tochimoto
  • Compounds, Compositions and Methods
    Publication number: 20090324511
    Abstract: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
    Type: Application
    Filed: May 20, 2009
    Publication date: December 31, 2009
    Inventors: Bradley P. Morgan, Alex Muci, Erica Kraynack, Pu-Ping Lu, Todd Tochimoto, David J. Morgans, JR.
  • CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS
    Publication number: 20090253737
    Abstract: Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of neuromuscular disorders, conditions having muscle wasting, claudication, frailty, metabolic syndrome, muscle atrophy associated with disuse, and muscle fatigue, and other indications.
    Type: Application
    Filed: February 2, 2009
    Publication date: October 8, 2009
    Inventors: Zhe YANG, Scott COLLIBEE, Alex MUCI, Jianchao WANG, Luke W. ASHCRAFT, Jeff GARDINA, Brian STOLTZ, Gustave BERGNES, Bradley P. MORGAN
  • Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols, compositions thereof, and methods for their use
    Patent number: 7598248
    Abstract: Provided is at least one chemical entity chosen from compounds of Formula I and compounds of Formula II: and pharmaceutically acceptable salts thereof, compositions thereof, and methods for their use in modulating of one or more of skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, skeletal muscle, and skeletal sarcomere.
    Type: Grant
    Filed: August 1, 2007
    Date of Patent: October 6, 2009
    Assignee: Cytokinetics, Inc.
    Inventors: Alex Muci, Jeffrey T. Finer, Pu-Ping Lu, Alan James Russell, Bradley P. Morgan, David J. Morgans, Jr.
  • Compounds, Compositions and Methods
    Publication number: 20090192168
    Abstract: Certain substituted urea derivatives modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
    Type: Application
    Filed: December 19, 2008
    Publication date: July 30, 2009
    Inventors: Alex Muci, Pu-Ping Lu, Bradley P. Morgan, David J. Morgans, JR.
  • Compounds, Compositions and Methods
    Publication number: 20090176307
    Abstract: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
    Type: Application
    Filed: January 5, 2009
    Publication date: July 9, 2009
    Inventors: Bradley Paul Morgan, Kathleen A. Elias, Erica Anne Kraynack, Pu-Ping Lu, Fady Malik, Alex Muci, Xiangping Qian, Whitney Walter Smith, Todd Tochimoto, Adam Lewis Tomasi, David J. Morgans, JR.