Abstract: A digital out-of-home network system for digital out-of-home applications and other types of advertising. A plurality of remote display units are included for video display of targeted advertising and digital media presentation. The media presentation systems and related methods may include advertising data servers that are preferably accessed wirelessly from a user work station. The work station may include a graphical user interface that allows the creation and scheduling of advertising content and assets to be displayed on remote display units located across selected regions. A user or advertiser may perform self-service operations such as creating and scheduling assets to be executed on selected windows or regions within any one or more video display units. The execution of assets and video clips on remote display units may be synchronized within a given unit or within a group of units residing in one or more locations.