Patents by Inventor Alex Okun
Alex Okun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20170143374Abstract: Embodiments of the present invention provide Dermal Micro-organs (DMOs), methods and apparatuses for harvesting the same. Some embodiments of the invention provide a DMO including a plurality of dermal components, which substantially retain the micro-architecture and three dimensional structure of the dermal tissue from which they are derived. An apparatus for harvesting the DMO may include, according to some exemplary embodiments, a support configuration to support a skin-related tissue structure from which the DMO is to be harvested, and a cutting tool able to separate the DMO from the skin-related tissue structure. Exemplary embodiments of the invention provide a genetically modified dermal micro-organ expressing at least one recombinant gene product. Some embodiments of the invention provide methods and apparatuses for implanting a genetically modified DMO.Type: ApplicationFiled: February 6, 2017Publication date: May 25, 2017Applicant: Medgenics Medical Israel Ltd.Inventors: Stephen F. Bellomo, Alex Okun, Yaron Fuerst, David Shalhevet, Elisha Amir, Mordechay Bukhman
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Patent number: 9572593Abstract: Embodiments of the present invention provide Dermal Micro-organs (DMOs), methods and apparatuses for harvesting the same. Some embodiments of the invention provide a DMO including a plurality of dermal components, which substantially retain the micro-architecture and three dimensional structure of the dermal tissue from which they are derived. An apparatus for harvesting the DMO may include, according to some exemplary embodiments, a support configuration to support a skin-related tissue structure from which the DMO is to be harvested, and a cutting tool able to separate the DMO to from the skin-related tissue structure. Exemplary embodiments of the invention provide a genetically modified dermal micro-organ expressing at least one recombinant gene product. Some embodiments of the invention provide methods and apparatuses for implanting a genetically modified DMO.Type: GrantFiled: July 1, 2015Date of Patent: February 21, 2017Assignee: Medgenics Medical Israel Ltd.Inventors: Stephen F. Bellomo, Alex Okun, Yaron Fuerst, David Shalhevet, Elisha Amir, Mordechay Bukhman
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Publication number: 20160000457Abstract: Embodiments of the present invention provide Dermal Micro-organs (DMOs), methods and apparatuses for harvesting the same. Some embodiments of the invention provide a DMO including a plurality of dermal components, which substantially retain the micro-architecture and three dimensional structure of the dermal tissue from which they are derived. An apparatus for harvesting the DMO may include, according to some exemplary embodiments, a support configuration to support a skin-related tissue structure from which the DMO is to be harvested, and a cutting tool able to separate the DMO to from the skin-related tissue structure. Exemplary embodiments of the invention provide a genetically modified dermal micro-organ expressing at least one recombinant gene product. Some embodiments of the invention provide methods and apparatuses for implanting a genetically modified DMO.Type: ApplicationFiled: July 1, 2015Publication date: January 7, 2016Applicant: Medgenics Medical Israel Ltd.Inventors: Stephen F. Bellomo, Alex Okun, Yaron Fuerst, David Shalhevet, Elisha Amir, Mordechay Bukhman
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Patent number: 9101595Abstract: Embodiments of the present invention provide Dermal Micro-organs (DMOs), methods and apparatuses for harvesting the same. Some embodiments of the invention provide a DMO including a plurality of dermal components, which substantially retain the micro-architecture and three dimensional structure of the dermal tissue from which they are derived. An apparatus for harvesting the DMO may include, according to some exemplary embodiments, a support configuration to support a skin-related tissue structure from which the DMO is to be harvested, and a cutting tool able to separate the DMO from the skin-related tissue structure. Exemplary embodiments of the invention provide a genetically modified dermal micro-organ expressing at least one recombinant gene product. Some embodiments of the invention provide methods and apparatuses for implanting a genetically modified DMO.Type: GrantFiled: December 2, 2012Date of Patent: August 11, 2015Assignee: Medgenics Medical Israel Ltd.Inventors: Stephen F. Bellomo, Alex Okun, Yaron Fuerst, David Shalhevet, Elisha Amir, Mordechay Bukhman
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Patent number: 8771291Abstract: Embodiments of the present invention provide Dermal Micro-organs (DMOs), methods and apparatuses for harvesting the same. Some embodiments of the invention provide a DMO including a plurality of dermal components, which substantially retain the micro-architecture and three dimensional structure of the dermal tissue from which they are derived. An apparatus for harvesting the DMO may include, according to some exemplary embodiments, a support configuration to support a skin-related tissue structure from which the DMO is to be harvested, and a cutting tool able to separate the DMO from the skin-related tissue structure. Exemplary embodiments of the invention provide a genetically modified dermal micro-organ expressing at least one recombinant gene product. Some embodiments of the invention provide methods and apparatuses for implanting a genetically modified DMO.Type: GrantFiled: November 28, 2012Date of Patent: July 8, 2014Assignee: Medgenics Medical Israel Ltd.Inventors: Stephen F. Bellomo, Alex Okun, Yaron Fuerst, David Shalhevet, Elisha Amir, Mordechay Bukhman
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Patent number: 8703491Abstract: Disclosed herein is a sample supply device that alternates between the supply of samples from one sample line while cleaning a second sample line and then supplying a second sample from the second sample line while cleaning the first sample line. This is repeated in rapid succession to allow greater speed in analyzing a plurality of samples in a shorter amount of time.Type: GrantFiled: November 16, 2012Date of Patent: April 22, 2014Assignee: Vivia Biotech S.L.Inventor: Alex Okun
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Patent number: 8313948Abstract: Disclosed herein is a sample supply device that alternates between the supply of samples from one sample line while cleaning a second sample line and then supplying a second sample from the second sample line while cleaning the first sample line. This is repeated in rapid succession to allow greater speed in analyzing a plurality of samples in a shorter amount of time.Type: GrantFiled: November 5, 2008Date of Patent: November 20, 2012Assignee: Vivia Biotech S.L.Inventor: Alex Okun
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Publication number: 20110065172Abstract: A system and method of mixing and injecting discrete sample mixtures into a flow cytometer or other sample analysis apparatus may generally comprise a sample injection guide coupling a liquid handling apparatus with a sample analysis apparatus and facilitating injection of discrete sample mixtures into a fluidic system of the apparatus.Type: ApplicationFiled: November 18, 2010Publication date: March 17, 2011Applicant: Saryna Biotechnologies LLCInventors: Alex Okun, Teresa A. Bennett, Andrew Beemink, David J. Sieg, John T. Ransom
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Patent number: 7858040Abstract: A system and method of mixing and injecting discrete sample mixtures into a flow cytometer or other sample analysis apparatus may generally comprise a sample injection guide coupling a liquid handling apparatus with a sample analysis apparatus and facilitating injection of discrete sample mixtures into a fluidic system of the apparatus.Type: GrantFiled: May 7, 2004Date of Patent: December 28, 2010Assignee: Saryna Biotechnologies LLCInventors: Alex Okun, Teresa A. Bennett, Andrew Beernink, David J. Sieg, John T. Ransom
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Publication number: 20090186374Abstract: An apparatus and method for real-time measurement of an effect of different concentrations of a test compound or series of test compounds on living cells, in which a flow of cell suspension is combined with a flow of the test compound and a cellular response of the living cells is repeatedly measured by a detector along a length of a detection zone where the cell suspension-test compound mixture is situated. The apparatus may be used in automated screening of libraries of compounds, and is capable of real-time variation of concentrations of test compounds and generation of three-dimensional dose/response/time profiles within a short timespan.Type: ApplicationFiled: February 21, 2008Publication date: July 23, 2009Applicant: Etogen ScientificInventors: Alex Okun, Gregory Kaler, Ilya Okun
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Publication number: 20090071268Abstract: Disclosed herein is a sample supply device that alternates between the supply of samples from one sample line while cleaning a second sample line and then supplying a second sample from the second sample line while cleaning the first sample line. This is repeated in rapid succession to allow greater speed in analyzing a plurality of samples in a shorter amount of time.Type: ApplicationFiled: November 5, 2008Publication date: March 19, 2009Applicant: SARYNA BIOTECHNOLOGIES LLCInventor: ALEX OKUN
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Patent number: 7459126Abstract: Disclosed herein is a sample supply device that alternates between the supply of samples from one sample line while cleaning a second sample line and then supplying a second sample from the second sample line while cleaning the first sample line. This is repeated in rapid succession to allow greater speed in analyzing a plurality of samples in a shorter amount of time.Type: GrantFiled: March 8, 2007Date of Patent: December 2, 2008Assignee: Saryna Biotechnologies LLCInventor: Alex Okun
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Publication number: 20070212784Abstract: Disclosed herein is a sample supply device that alternates between the supply of samples from one sample line while cleaning a second sample line and then supplying a second sample from the second sample line while cleaning the first sample line. This is repeated in rapid succession to allow greater speed in analyzing a plurality of samples in a shorter amount of time.Type: ApplicationFiled: March 8, 2007Publication date: September 13, 2007Applicant: MCU DESIGNS, INC.Inventor: Alex Okun
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Publication number: 20050249642Abstract: A system and method of mixing and injecting discrete sample mixtures into a flow cytometer or other sample analysis apparatus may generally comprise a sample injection guide coupling a liquid handling apparatus with a sample analysis apparatus and facilitating injection of discrete sample mixtures into a fluidic system of the apparatus.Type: ApplicationFiled: May 7, 2004Publication date: November 10, 2005Applicant: Novasite Pharmaceuticals, Inc.Inventors: Alex Okun, John Ransom
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Publication number: 20050249635Abstract: A system and method of mixing and injecting discrete sample mixtures into a flow cytometer or other sample analysis apparatus may generally comprise a sample injection guide coupling a liquid handling apparatus with a sample analysis apparatus and facilitating injection of discrete sample mixtures into a fluidic system of the apparatus.Type: ApplicationFiled: May 7, 2004Publication date: November 10, 2005Applicant: Novasite Pharmaceuticals, Inc.Inventors: Alex Okun, Teresa Bennett, Andrew Beemink, David Sieg, John Ransom
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Publication number: 20050021241Abstract: The present disclosure provides compositions and methods for high throughput Gain of Function (GOF) sorting to discover and develop novel and highly selective candidate drug molecules. High throughput GOF sorting includes: mutating a single residue in a receptor and/or ligand; measuring the affinity and functional activity of the resulting ligand target-ligand interaction; and carrying out multiple rounds of mutation and measurement to determine which residues provide key interaction points underlying the functional activity of a ligand target-ligand interaction. Further, the present disclosure provides methods and compositions for high throughput and high precision GOF sorting, such that large numbers of mutations can be generated and screened rapidly, and GOF compounds can be identified and isolated.Type: ApplicationFiled: May 7, 2004Publication date: January 27, 2005Inventors: Juan Ballesteros, Teresa Bennett, Alex Okun, Andrew Beernink, John Ransom
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Publication number: 20050009060Abstract: The present disclosure provides systems for multiplexed multitarget screening of cell populations having one or more wild type or mutated ligand targets and measuring cell responses to ligands using high throughput screening techniques, including flow cytometry (FCM). The method includes the steps of: 1) developing cell populations to be screened; 2) staining cell populations using one or more fluorochromes to yield a distinct excitation/emission signature for each cell population; 3) combining labelled cell populations into a single mixed suspension; 4) analyzing populations to resolve them on the basis of their unique signature; and 5) resolving individual populations and deconvoluting data to extract meaningful information about populations.Type: ApplicationFiled: May 7, 2004Publication date: January 13, 2005Inventors: Andrew Beernink, Teresa Bennett, Alex Okun, Juan Ballesteros, John Ransom
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Patent number: 6379917Abstract: An apparatus and method for real-time measurement of a cellular response of a test compound or series of test compounds (303) on a flowing suspension of cells (349), in which a homogenous suspension of each member of a series of cell types (349) is combined with a concentration of a test compound (303), directed through a detection zone (355), and a cellular response of the living cells is measured in real time as the cells in the test mixture are flowing through the detection zone (355). The apparatus may be used in automated screening of libraries of compounds, and is capable of real-time variation of concentrations of test and standard compounds and generation of dose/response profiles within a short timespan.Type: GrantFiled: July 28, 2000Date of Patent: April 30, 2002Assignee: Axiom BiotechnologiesInventors: Ilya Okun, Alex Okun
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Patent number: 6287758Abstract: Sensitive methods for identifying compounds having biological activity comprising combining living cells with two fluorescent membrane permeable ionic dyes having the same charge sign, the first of which has an emission spectrum which overlaps the excitation spectrum of the second fluorescent membrane penetrative dye. The fluorescence is then induced by illuminating the dyes at a wavelength corresponding to the excitation spectrum of the first fluorescent dye and emission is then registered at a wavelength corresponding to the emission spectrum of the second fluorescent dye (FRET). The change in the FRET is indicative of a modulation of cell membrane potential by the biologically active compounds.Type: GrantFiled: March 23, 2000Date of Patent: September 11, 2001Assignee: Axiom Biotechnologies, Inc.Inventors: Ilya Okun, Alex Okun, Gregory Kaler
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Patent number: 6280967Abstract: An apparatus and method for real-time measurement of a cellular response of a test compound or series of test compounds (303) on a flowing suspension of cells (349), in which a homogeneous suspension of each member of a series of cell types (349) is combined with a concentration of a test compound (303), directed through a detection zone (355), and a cellular response of the living cells is measured in real time as the cells in the test mixture are flowing through the detection zone (355). The apparatus may be used in automated screening of libraries of compounds, and is capable of real-time variation of concentrations of test and standard compounds and generation of dose/response profiles within a short time span.Type: GrantFiled: August 5, 1999Date of Patent: August 28, 2001Assignee: Axiom Biotechnologies, Inc.Inventors: John Ransom, Ilya Okun, Alex Okun