Patents by Inventor Alex Petrolati

Alex Petrolati has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystal forms of lenvatinib
    Patent number: 10836727
    Abstract: The present invention provides novel crystalline forms of 4-[3-Chloro-4-(N?-cyclopropylureido)phenoxy]-7-methoxyquinoline-6-carboxamide methanesulfonate, as well as methods for their preparation.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: November 17, 2020
    Assignee: Indena S.P.A.
    Inventors: Nicola Sardone, Stefano Luca Giaffreda, Andrea Gambini, Alex Petrolati, Pietro Allegrini, Enrico Modena
  • Polymorph of sodium neridronate and preparation process thereof
    Patent number: 10815257
    Abstract: The present invention relates to a novel crystalline hemihydrate polymorph of neridronic acid sodium salt, and a novel process for the preparation thereof comprising the steps of: 1) dissolving solid sodium neridronate in any crystalline form in water, at a temperature in the range from 70 to 90° C., to obtain an aqueous solution of sodium neridronate; 2) adding a solvent selected from the group consisting in ethanol, 1-propanol, and 2-propanol to the aqueous solution obtained from step (1), so that the final water:solvent volume ratio is in the range from 1:0.5 to 1:1, thus obtaining a suspension; 3) placing the suspension obtained from step (2) under mechanical stirring, at a temperature in the range from 60 to 95° C.; 4) recovering the crystalline hemihydrate form F of sodium neridronate formed in the previous step (3).
    Type: Grant
    Filed: April 10, 2019
    Date of Patent: October 27, 2020
    Assignee: ABIOGEN PHARMA S.P.A.
    Inventors: Laura Dini, Fabio Neggiani, Barbara Politi, Stefano Luca Giaffreda, Alex Petrolati, Michel Chiarucci, Serena Fabbroni, Kesheng Zhang, Michael Roeder
  • POLYMORPH OF SODIUM NERIDRONATE AND PREPARATION PROCESS THEREOF
    Publication number: 20190308999
    Abstract: The present invention relates to a novel crystalline hemihydrate polymorph of neridronic acid sodium salt, and a novel process for the preparation thereof comprising the steps of: 1) dissolving solid sodium neridronate in any crystalline form in water, at a temperature in the range from 70 to 90° C., to obtain an aqueous solution of sodium neridronate; 2) adding a solvent selected from the group consisting in ethanol, 1-propanol, and 2-propanol to the aqueous solution obtained from step (1), so that the final water:solvent volume ratio is in the range from 1:0.5 to 1:1, thus obtaining a suspension; 3) placing the suspension obtained from step (2) under mechanical stirring, at a temperature in the range from 60 to 95° C.; 4) recovering the crystalline hemihydrate form F of sodium neridronate formed in the previous step (3).
    Type: Application
    Filed: April 10, 2019
    Publication date: October 10, 2019
    Applicant: ABIOGEN PHARMA S.P.A.
    Inventors: Laura Dini, Fabio Neggiani, Barbara Politi, Stefano Luca Giaffreda, Alex Petrolati, Michel Chiarucci, Serena Fabbroni, Kesheng Zhang, Michael Roeder
  • NEW CRYSTAL FORMS OF LENVATINIB
    Publication number: 20190256473
    Abstract: The present invention provides novel crystalline forms of 4-[3-Chloro-4-(N?-cyclopropylureido)phenoxy]-7-methoxyquinoline-6-carboxamide methanesulfonate, as well as methods for their preparation.
    Type: Application
    Filed: September 15, 2017
    Publication date: August 22, 2019
    Applicant: Indena S.P.A.
    Inventors: Nicola Sardone, Stefano Luca Giaffreda, Andrea Gambini, Alex Petrolati, Pietro Allegrini, Enrico Modena