Abstract: The disclosure provides fusion proteins useful for detecting and quantifying cyclic dinucleotides. The fusion proteins can comprise a functional cyclic dinucleotide binding domain linked to a first fluorescent domain and a second fluorescent domain. The first fluorescent domain and a second fluorescent domain can produce a detectable signal when brought into sufficiently close proximity, such as a FRET pair or split luciferase. The fusion protein can be used to assay the presence and/or concentration of cyclic dinucleotides in vitro or in a cell. The method of use include monitoring the cyclic dinucleotide activity, or activity of cyclic dinucleotide synthases. Furthermore, the methods can include screening compounds that may modulate cyclic dinucleotide activity, production, importation, and the like.

Abstract: Systems and methods for automatically generating targeting information for presentation of an offer in accordance with embodiments of the invention are disclosed. One embodiment includes indexing member profiles within one or more social networks for affinity to keywords using a targeting system that retrieves data concerning member profiles and activities from servers within an online social network, identifying member profiles that have affinity for at least one offer keyword using the targeting system and the index, identifying additional keywords for which the identified member profiles have affinity using the targeting system and the index, determining a set of keywords that target a desired audience based upon the identified additional keywords using the targeting server, and targeting presentation of advertisements for the specific offer to members of an online social network using the online social network and the targeting keywords determined by the targeting server.

Abstract: Systems and methods for automatically generating targeting information for presentation of an offer in accordance with embodiments of the invention are disclosed. One embodiment includes indexing member profiles within one or more social networks for affinity to keywords using a targeting system that retrieves data concerning member profiles and activities from servers within an online social network, identifying member profiles that have affinity for at least one offer keyword using the targeting system and the index, identifying additional keywords for which the identified member profiles have affinity using the targeting system and the index, determining a set of keywords that target a desired audience based upon the identified additional keywords using the targeting server, and targeting presentation of advertisements for the specific offer to members of an online social network using the online social network and the targeting keywords determined by the targeting server.

Abstract: Systems and methods for automatically generating targeting information for presentation of an offer via an online social network using affinity information collected concerning members of online social networks in accordance with embodiments of the invention are disclosed.

Abstract: Systems and methods for automatically generating targeting information for presentation of an offer via an online social network using affinity information collected concerning members of online social networks in accordance with embodiments of the invention are disclosed.