Abstract: Provided are compositions that include compositions of galactosyl-conjugated lipid nanoparticles (LNPs) encapsulating one or more active agents. In some embodiments, the galactosyl-conjugated LNPs have a lipid component having D-Lin-MC3-DMA, ALC-0315 and SM-102, cholesterol. DSPC and DOPE, and DMG-2000-PEG. In some embodiments, the GalNAc-conjugated LNP has one or more galactosyl moieties bioconjugated to cholesterol present with a lipid component of the GalNAc-conjugated LNP. Also provided are methods for treating and/or preventing diseases, disorders, and/or conditions associated with undesirable PCSK9 gene expression, optionally a cardiovascular disease, disorder, or condition, including but not limited to atherosclerosis and/or thrombosis, and sepsis, septic shock, cytokine storm, or sequelae thereof.

Abstract: Systems and methods for traversal selection of components of a geometric model are disclosed. An embodiment includes displaying a plurality of components corresponding to a geometric model, selecting a first component, receiving a first input indicating a first direction for selecting a next component, wherein the next component is connected to the first component by an edge, identifying one or more candidate edges connected to the first component for selecting the next component, determining an angle between an indicated direction vector corresponding to the indicated first direction and each of the one or more candidate edges, and selecting a second component as the next component, wherein the second component is connected to the first component via a particular candidate edge forming a smallest angle with the indicated direction vector.

Abstract: Systems and methods for traversal selection of components of a geometric model are disclosed. An embodiment includes displaying a plurality of components corresponding to a geometric model, selecting a first component, receiving a first input indicating a first direction for selecting a next component, wherein the next component is connected to the first component by an edge, identifying one or more candidate edges connected to the first component for selecting the next component, determining an angle between an indicated direction vector corresponding to the indicated first direction and each of the one or more candidate edges, and selecting a second component as the next component, wherein the second component is connected to the first component via a particular candidate edge forming a smallest angle with the indicated direction vector.

Abstract: Systems and methods for traversal selection of components of a geometric model are disclosed. An embodiment includes displaying a plurality of components corresponding to a geometric model, selecting a first component, receiving a first input indicating a first direction for selecting a next component, wherein the next component is connected to the first component by an edge, identifying one or more candidate edges connected to the first component for selecting the next component, determining an angle between an indicated direction vector corresponding to the indicated first direction and each of the one or more candidate edges, and selecting a second component as the next component, wherein the second component is connected to the first component via a particular candidate edge forming a smallest angle with the indicated direction vector.

Abstract: An arterial emboli dissolution filter apparatus is a permanently implanted for the prevention of embolic occlusion of a blood vessel. The dissolution filter comprises an anchor section, wherein the anchor section is similar to a stent. The dissolution filter is attached to the anchor section. The device is designed so that normal blood can flow freely though the filter element while any potential embolism will be retained by the filtering element. The passing blood flow is used to dissolve and dissolve any retained emboli. The dissolution filter is fabricated of any reasonably arranged lattice elements forming a series of mesh pores. The filter material and design directs the emboli and blood flow towards a central location, thus increasing the efficiency in dissolving the emboli.