Patents by Inventor Alex Sokoloff

Alex Sokoloff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Trail compositions with reduced immunogenicity
    Patent number: 11767353
    Abstract: Fusion polypeptides with modified multimerization domains that provide high expression, solubility, stability, and low immunogenicity to the fusion polypeptides have been developed. TRAIL compositions with the modified multimerization domains show improved physico-chemical and biological properties relative to TRAIL compositions with unmodified multimerization domains. The TRAIL compositions also have lower immunogenicity in the mammalian host when compared to that of TRAIL compositions with unmodified multimerization domains. The TRAIL compositions induce apoptosis of cancer cells and cancer-associated fibroblasts in vivo, reducing tumor size.
    Type: Grant
    Filed: April 6, 2021
    Date of Patent: September 26, 2023
    Assignee: THERALY FIBROSIS, INC.
    Inventors: Alex Sokoloff, Viktor Roschke, Kang Choon Lee, Seulki Lee, Yumin Oh
  • TRAIL COMPOSITIONS WITH REDUCED IMMUNOGENICITY
    Publication number: 20210380653
    Abstract: Fusion polypeptides with modified multimerization domains that provide high expression, solubility, stability, and low immunogenicity to the fusion polypeptides have been developed. TRAIL compositions with the modified multimerization domains show improved physico-chemical and biological properties relative to TRAIL compositions with unmodified multimerization domains. The TRAIL compositions also have lower immunogenicity in the mammalian host when compared to that of TRAIL compositions with unmodified multimerization domains. The TRAIL compositions induce apoptosis of cancer cells and cancer-associated fibroblasts in vivo, reducing tumor size.
    Type: Application
    Filed: April 6, 2021
    Publication date: December 9, 2021
    Inventors: Alex Sokoloff, Viktor Roschke, Kang Choon Lee, Seulki Lee, Yumin Oh