Abstract: The present disclosure relates to regulation of macrophage activation by delivering of miRNAs, for example miR-125b or anti-miR-125b, to macrophages. For example, in some embodiments, macrophage activation can be elevated or reduced by administering miR-125b or anti-miR-125b oligonucleotides. Also disclosed are methods for promoting T cell activation and method for treating various disorders such as tumor and autoimmune diseases.

Abstract: Methods and systems of traffic routing in a circuit switched communication network having a plurality of switches and a plurality of trunk groups connecting the switches are disclosed. The methods include a step of determining a set of alternate routing paths for each of a plurality of ordered pairs of the switches, wherein the number of alternate routing paths through each of the trunk groups is constrained to be less than a corresponding first predetermined threshold. In one embodiment, the alternate routing paths are determined by computing a solution to a predetermined integer programming problem. In another embodiment, a heuristic technique is used to determine the alternate routing paths.