Abstract: Disclosed herein is a device and method for delivery of supplemental oxygen in a healthcare environment such that flow rate of delivered oxygen is dependent on input data of patient oxygen saturation values and other physiologic variables. The output of oxygen is modulated by an algorithm which may be pre-set or altered by the user in which variables such as desired range of oxygen saturation, oxygen flow rate of change, time response and alarm settings may be altered. User interaction may be accomplished via interface on the device itself comprising of a touchscreen, buttons or dial system or via interaction with a second device such as a patient vitals monitor or computer, which may interact with the device by direct connection or network connection. The device may be used to maintain a state of adequate oxygenation in the patient by increasing or decreasing oxygen flow, or to facilitate weaning and cessation of oxygen use.