Patents by Inventor Alex Yee-Chen Huang

Alex Yee-Chen Huang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods of treating sarcoma lung metastasis
    Patent number: 11911468
    Abstract: A method of treating pulmonary metastasis of osteosarcoma cells (pOSs) in a subject in need thereof includes administering to the subject a therapeutically effective amount of an agent that interferes with VCAM-1/?4?1 signaling between pOSs expressing VCAM-1 and pulmonary macrophages (MACs) expressing ?4?1.
    Type: Grant
    Filed: May 4, 2021
    Date of Patent: February 27, 2024
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Alex Yee-Chen Huang, Jay T. Myers
  • Methods of sensitizing cancer to immunotherapy
    Patent number: 11884730
    Abstract: A method of sensitizing cancer to immunotherapy in a subject in need thereof includes administering to the subject a therapeutically effective amount of a CdK5 inhibitor to suppress immune checkpoint PD-L1.
    Type: Grant
    Filed: September 21, 2021
    Date of Patent: January 30, 2024
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Alex Yee-Chen Huang, Agne Petrosiute
  • METHODS OF SENSITIZING CANCER TO IMMUNOTHERAPY
    Publication number: 20230192863
    Abstract: A method of sensitizing cancer to immunotherapy in a subject in need thereof includes administering to the subject a therapeutically effective amount of a CdK5 inhibitor to suppress immune checkpoint PD-L1.
    Type: Application
    Filed: February 10, 2023
    Publication date: June 22, 2023
    Inventors: Muta Abiff, Alex Yee-Chen Huang
  • METHODS OF SENSITIZING CANCER TO IMMUNOTHERAPY
    Publication number: 20220169735
    Abstract: A method of sensitizing cancer to immunotherapy in a subject in need thereof includes administering to the subject a therapeutically effective amount of a CdK5 inhibitor to suppress immune checkpoint PD-L1.
    Type: Application
    Filed: September 21, 2021
    Publication date: June 2, 2022
    Inventors: Alex Yee-Chen Huang, Agne Petrosiute
  • COMPOSITIONS AND METHODS OF TREATING SARCOMA LUNG METASTASIS
    Publication number: 20210393774
    Abstract: A method of treating pulmonary metastasis of osteosarcoma cells (pOSs) in a subject in need thereof includes administering to the subject a therapeutically effective amount of an agent that interferes with VCAM-1/?4?1 signaling between pOSs expressing VCAM-1 and pulmonary macrophages (MACs) expressing ?4?1.
    Type: Application
    Filed: May 4, 2021
    Publication date: December 23, 2021
    Inventors: Alex Yee-Chen Huang, Jay T. Myers
  • Methods of sensitizing cancer to immunotherapy
    Patent number: 11124571
    Abstract: A method of sensitizing cancer to immunotherapy in a subject in need thereof includes administering to the subject a therapeutically effective amount of a CdK5 inhibitor to suppress immune checkpoint PD-L1.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: September 21, 2021
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Alex Yee-Chen Huang, Agne Petrosiute
  • Compositions and methods of treating sarcoma lung metastasis
    Patent number: 10994009
    Abstract: A method of treating pulmonary metastasis of osteosarcoma cells (pOSs) in a subject in need thereof includes administering to the subject a therapeutically effective amount of an agent that interferes with VCAM-1/?4?1 signaling between pOSs expressing VCAM-1 and pulmonary macrophages (MACs) expressing ?4?1.
    Type: Grant
    Filed: June 26, 2018
    Date of Patent: May 4, 2021
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Alex Yee-Chen Huang, Jay T. Myers
  • METHODS OF SENSITIZING CANCER TO IMMUNOTHERAPY
    Publication number: 20190194330
    Abstract: A method of sensitizing cancer to immunotherapy in a subject in need thereof includes administering to the subject a therapeutically effective amount of a CdK5 inhibitor to suppress immune checkpoint PD-L1.
    Type: Application
    Filed: May 24, 2017
    Publication date: June 27, 2019
    Inventors: Alex Yee-Chen Huang, Agne Petrosiute
  • COMPOSITIONS AND METHODS OF TREATING SARCOMA LUNG METASTASIS
    Publication number: 20180369372
    Abstract: A method of treating pulmonary metastasis of osteosarcoma cells (pOSs) in a subject in need thereof includes administering to the subject a therapeutically effective amount of an agent that interferes with VCAM-1/?4?1 signaling between pOSs expressing VCAM-1 and pulmonary macrophages (MACs) expressing ?4?1.
    Type: Application
    Filed: June 26, 2018
    Publication date: December 27, 2018
    Inventors: Alex Yee-Chen Huang, Jay T. Myers