Patents by Inventor Alexander A. Kolykhalov

Alexander A. Kolykhalov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ALKYNE CONTAINING NUCLEOTIDE AND NUCLEOSIDE THERAPEUTIC COMPOSITIONS AND USES RELATED THERETO
    Publication number: 20230062181
    Abstract: This disclosure relates to nucleotide and nucleoside therapeutic compounds and uses in treating infectious diseases viral infections, and cancer, where the base of the nucleotide or nucleoside contains at least one thiol, thione or thioether.
    Type: Application
    Filed: October 5, 2021
    Publication date: March 2, 2023
    Inventors: Gregory Bluemling, Abel de la Rosa, George Painter, Damien Kuiper, Alexander Kolykhalov
  • Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto
    Patent number: 11192914
    Abstract: This disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in treating infectious diseases, viral infections, and cancer, where the nucleotide or nucleoside is defined by Formula I below,
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: December 7, 2021
    Assignee: Emory University
    Inventors: Gregory Bluemling, Abel De La Rosa, George Painter, Damien Kuiper, Alexander Kolykhalov
  • ALKYNE CONTAINING NUCLEOTIDE AND NUCLEOSIDE THERAPEUTIC COMPOSITIONS AND USES RELATED THERETO
    Publication number: 20190144484
    Abstract: This disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in treating infectious diseases, viral infections, and cancer, where the base of the nucleotide or nucleoside contains at least one thiol, thione or thioether.
    Type: Application
    Filed: April 28, 2017
    Publication date: May 16, 2019
    Inventors: Gregory BLUEMLING, Abel DE LA ROSA, George PAINTER, Damien KUIPER, Alexander KOLYKHALOV
  • RNAI EXPRESSION CONSTRUCTS
    Publication number: 20150197751
    Abstract: The present invention provides compositions and methods suitable for expressing 1-x RNAi agents against a gene or genes in cells, tissues or organs of interest in vitro and in vivo so as to treat diseases or disorders.
    Type: Application
    Filed: March 30, 2015
    Publication date: July 16, 2015
    Inventors: Petrus W. Roelvink, David A. Suhy, Alexander A. Kolykhalov, Linda Couto
  • RNAi expression constructs
    Patent number: 8993530
    Abstract: The present invention provides compositions and methods suitable for expressing 1-x RNAi agents against a gene or genes in cells, tissues or organs of interest in vitro and in vivo so as to treat diseases or disorders.
    Type: Grant
    Filed: November 10, 2011
    Date of Patent: March 31, 2015
    Assignee: Benitec, Inc.
    Inventors: Petrus W. Roelvink, David A. Suhy, Alexander A. Kolykhalov, Linda Couto
  • Multiple promoter expression cassettes for simultaneous delivery of RNAi agents
    Patent number: 8691967
    Abstract: The present invention provides multiple-promoter expression cassettes for simultaneous delivery of RNAi, preferably to mammalian cells in vivo.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: April 8, 2014
    Assignee: Benitec, Inc.
    Inventors: Petrus W. Roelvink, David A. Suhy, Alexander A. Kolykhalov
  • Multiple promoter expression cassettes for simultaneous delivery of RNAi agents
    Patent number: 8283461
    Abstract: The present invention provides multiple-promoter expression cassettes for simultaneous delivery of RNAi, preferably to mammalian cells in vivo.
    Type: Grant
    Filed: March 12, 2010
    Date of Patent: October 9, 2012
    Assignee: Benitec, Inc.
    Inventors: Petrus W. Roelvink, David A. Suhy, Alexander A. Kolykhalov
  • RNAi EXPRESSION CONSTRUCTS
    Publication number: 20120058555
    Abstract: The present invention provides compositions and methods suitable for expressing 1-x RNAi agents against a gene or genes in cells, tissues or organs of interest in vitro and in vivo so as to treat diseases or disorders.
    Type: Application
    Filed: November 10, 2011
    Publication date: March 8, 2012
    Applicant: Benitec, Inc.
    Inventors: Petrus W. Roelvink, David A. Suhy, Alexander A. Kolykhalov, Linda Couto
  • RNAi expression constructs
    Patent number: 8076471
    Abstract: The present invention provides compositions and methods suitable for expressing 1-x RNAi agents against a gene or genes in cells, tissues or organs of interest in vitro and in vivo so as to treat diseases or disorders.
    Type: Grant
    Filed: February 3, 2006
    Date of Patent: December 13, 2011
    Assignee: Benitec, Inc.
    Inventors: Petrus W. Roelvink, David A. Suhy, Alexander A. Kolykhalov, Linda Couto
  • RNAi expression constructs with liver-specific enhancer/promoter
    Patent number: 8008468
    Abstract: The present invention provides compositions and methods suitable for RNAi specifically in the liver so as to treat diseases or disorders.
    Type: Grant
    Filed: February 16, 2006
    Date of Patent: August 30, 2011
    Assignee: Benitec, Inc.
    Inventors: Petrus W. Roelvink, David A. Suhy, Alexander A. Kolykhalov, Mark A. Kay, Jeffery C. Giering
  • DOUBLE-STRANDED NUCLEIC ACID
    Publication number: 20110117608
    Abstract: The invention is directed towards constructs for RNAi techniques. The invention provides a ribonucleic acid (RNA) for use as interfering RNA in gene silencing techniques to silence a target gene comprising in a 5? to 3? direction at least a first effector sequence, a second effector sequence, a sequence substantially complementary to the second effector sequence and a sequence substantially complementary to the first effector sequence, wherein the complementary sequences are capable of forming double stranded regions with their respective effector sequences and wherein at least one of these sequences is substantially identical to the predicted transcript of a region of the target gene, and a nucleic acid construct encoding such an RNA.
    Type: Application
    Filed: October 28, 2010
    Publication date: May 19, 2011
    Applicant: BENITEC AUSTRALIA, LTD.
    Inventors: MICHAEL WAYNE GRAHAM, KENNETH CLIFFORD REED, ROBERT NORMAN RICE, BRUCE THOMAS HARRISON, PETRUS ROELVINK, DAVID SUHY, ALEXANDER KOLYKHALOV
  • MULTIPLE PROMOTER EXPRESSION CASSETTES FOR SIMULTANEOUS DELIVERY OF RNAi AGENTS
    Publication number: 20110003378
    Abstract: The present invention provides multiple-promoter expression cassettes for simultaneous delivery of RNAi, preferably to mammalian cells in vivo.
    Type: Application
    Filed: March 12, 2010
    Publication date: January 6, 2011
    Applicant: BENITEC, INC.
    Inventors: PETRUS W. ROELVINK, DAVID A. SUHY, ALEXANDER A. KOLYKHALOV
  • RNAi expression constructs
    Patent number: 7803611
    Abstract: The present invention provides compositions and methods suitable for expressing 1-x RNAi agents against a gene or genes in cells, tissues or organs of interest in vitro and in vivo so as to treat diseases or disorders.
    Type: Grant
    Filed: February 3, 2006
    Date of Patent: September 28, 2010
    Assignee: Benitec, Inc.
    Inventors: Petrus W. Roelvink, David A. Suhy, Alexander A. Kolykhalov, Linda Couto
  • Multiple promoter expression cassettes for simultaneous delivery of RNAi agents targeted to Hepatitis C virus
    Patent number: 7727970
    Abstract: The present invention provides multiple-promoter expression cassettes for simultaneous delivery of RNAi, preferably to mammalian cells in vivo.
    Type: Grant
    Filed: March 4, 2005
    Date of Patent: June 1, 2010
    Assignee: Benitec, Inc.
    Inventors: Petrus W. Roelvink, David A. Suhy, Alexander A. Kolykhalov
  • RNAi Expression Constructs
    Publication number: 20100028998
    Abstract: The present invention provides compositions and methods suitable for expressing 1-x RNAi agents against a gene or genes in cells, tissues or organs of interest in vitro and in vivo so as to treat diseases or disorders.
    Type: Application
    Filed: February 3, 2006
    Publication date: February 4, 2010
    Applicant: Benitec, Inc.
    Inventors: Petrus W. Roelvink, David A. Suhy, Alexander A. Kolykhalov, Linda Couto
  • Functional DNA clone for hepatitis C virus (HCV) and uses thereof
    Patent number: 7235394
    Abstract: The present invention relates to the determination of an authentic HCV genome RNA sequences, to construction of infectious HCV DNA clones, and to use of the clones, or their derivatives, in therapeutic, vaccine, and diagnostic applications. The invention is also directed to HCV vectors, e.g., for gene therapy of gene vaccines.
    Type: Grant
    Filed: November 6, 2003
    Date of Patent: June 26, 2007
    Assignee: Washington University
    Inventors: Charles M. Rice, Alexander A. Kolykhalov
  • RNAi expression constructs
    Publication number: 20070025969
    Abstract: The present invention provides compositions and methods suitable for expressing 1-x RNAi agents against a gene or genes in cells, tissues or organs of interest in vitro and in vivo so as to treat diseases or disorders.
    Type: Application
    Filed: February 3, 2006
    Publication date: February 1, 2007
    Inventors: Petrus Roelvink, David Suhy, Alexander Kolykhalov, Linda Couto
  • Method for detection and characterization of short nucleic acids
    Publication number: 20070020644
    Abstract: A method of detecting and characterizing a target short RNA is provided.
    Type: Application
    Filed: January 26, 2006
    Publication date: January 25, 2007
    Inventors: Alexander Kolykhalov, A. Schroeder
  • RNAi expression constructs with liver-specific enhancer/promoter
    Publication number: 20060189561
    Abstract: The present invention provides compositions and methods suitable for RNAi specifically in the liver so as to treat diseases or disorders.
    Type: Application
    Filed: February 16, 2006
    Publication date: August 24, 2006
    Inventors: Petrus Roelvink, David Suhy, Alexander Kolykhalov, Mark Kay, Jeffery Giering
  • 3?terminal sequence of hepatitis C virus genome and diagnostic and therapeutic uses thereof
    Patent number: 6943246
    Abstract: The invention relates to the discovery of a novel RNA sequence at the 3? terminal sequence of hepatitis C virus (HCV) genome RNA. Included in the invention are the 3? sequence, its complement, and their use for nucleic-acid based diagnostics and for developing and evaluating novel anti-HCV therapies. This sequence element, which is conserved among HCV genotypes, is likely to be essential for viral replication, and required for construction of full-length HCV cDNA clones capable of yielding infectious RNA, progeny virus or replication-competent HCV replicons. Such functional clones are useful tools for evaluation of therapeutic approaches and as substrates for developing candidate attenuated or inactivated HCV derivatives for vaccination against HCV.
    Type: Grant
    Filed: May 30, 2002
    Date of Patent: September 13, 2005
    Assignee: Washington University
    Inventors: Charles M. Rice, Alexander A. Kolykhalov