Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having core structure (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies employing those modulators, and processes and intermediates for making such modulators.

Abstract: The disclosure provides a method for cleaning an implanted medical device. In one embodiment, the method includes providing a medical device including a membrane; wherein the membrane comprises a thermoresponsive hydrogel including N-isopropylacrylamide (NIPAAm) or poly(N-isopropylacrylamide) (PNIPAAm), and a volume phase transition temperature (VPTT). The method also includes implanting the medical device into a target area; wherein the membrane temperature is maintained at substantially the same temperature as the target area; wherein temperature fluctuations within the target area that approach, meet and/or exceed the volume phase transition temperature induce deswelling or relative deswelling in the membrane and temperature fluctuations within the target area that are relatively lower and/or approach and/or fall below the volume phase transition temperature induce swelling or relative swelling in the membrane.

Abstract: A plurality of devices communicate over a bus, the devices comprising a plurality of controller devices and a plurality of second devices. Each of the controller devices is responsible for assigning one or more of the addresses including at least the address of each of a respective one or more of the second devices. A controller device comprises address allocation logic configured to assign an address to each of that controller device's respective one or more second devices, by: searching for a currently unassigned address to assign to each of the respective one or more second devices, and if an unassigned address for one of those one or more second devices cannot be found, to issue a request to at least one other of the controller devices requesting that the other controller device changes one of the one or more addresses which that other controller device is responsible for assigning.

Abstract: A control device, kit, and method is disclosed that control operation of a window covering. The control device, kit, and method use a controller. The controller is configured to, in response to an input from the at least one sensor and one or more additional inputs, a) create a ranking of preferences based on the inputs, b) select one or more preferences from the ranking of preferences, and c) actuate the motor to rotate the rotatable adapter based on the selected one or more preferences obtained from ranking of preferences, such that 1) when the rotatable adapter is engaged with the cord of the window covering and 2) the motor rotates, the window covering moves between a first configuration and a second configuration that is different than the first configuration.

Abstract: A control device, kit, and method is disclosed that control operation of a window covering. The control device, kit, and method use a controller. The controller is configured to, in response to an input from the at least one sensor and one or more additional inputs, a) create a ranking of preferences based on the inputs, b) select one or more preferences from the ranking of preferences, and c) actuate the motor to rotate the rotatable adapter based on the selected one or more preferences obtained from ranking of preferences, such that 1) when the rotatable adapter is engaged with the cord of the window covering and 2) the motor rotates, the window covering moves between a first configuration and a second configuration that is different than the first configuration.

Abstract: A plurality of devices communicate over a bus, the devices comprising a plurality of controller devices and a plurality of second devices. Each of the controller devices is responsible for assigning one or more of the addresses including at least the address of each of a respective one or more of the second devices. A controller device comprises address allocation logic configured to assign an address to each of that controller device's respective one or more second devices, by: searching for a currently unassigned address to assign to each of the respective one or more second devices, and if an unassigned address for one of those one or more second devices cannot be found, to issue a request to at least one other of the controller devices requesting that the other controller device changes one of the one or more addresses which that other controller device is responsible for assigning.

Abstract: Multiple master modules are connected to a bus, each having bus communication logic for initiating a transaction over the bus. The bus communication logic is able to detect when the bus is busy (or apparently busy), and in response will wait before initiating a transaction of its own. Further, a distributed reset sub-system is provided, comprising an instance of a reset mechanism at each of a plurality of the master modules. Each reset mechanism recognizes a timeout condition indicative of the detected busy state being due to error, and in response performs a staged reset. This reset process first attempts a local reset which resets the respective bus communication logic of its respective master module. If the local reset fails to clear the error, the staged reset process then attempts one or more further resets to reset bus communication logic of one or more other modules connected to the bus.

Abstract: A plurality of devices communicate over a bus, the devices comprising a plurality of controller devices and a plurality of second devices. Each of the controller devices is responsible for assigning one or more of the addresses including at least the address of each of a respective one or more of the second devices. A controller device comprises address allocation logic configured to assign an address to each of that controller device's respective one or more second devices, by: searching for a currently unassigned address to assign to each of the respective one or more second devices, and if an unassigned address for one of those one or more second devices cannot be found, to issue a request to at least one other of the controller devices requesting that the other controller device changes one of the one or more addresses which that other controller device is responsible for assigning.

Abstract: The disclosure provides a method for cleaning an implanted medical device. In one embodiment, the method includes providing a medical device including a membrane; wherein the membrane comprises a thermoresponsive hydrogel including N-isopropylacrylamide (NIPAAm) or poly(N-isopropylacrylamide) (PNIPAAm), and a volume phase transition temperature (VPTT). The method also includes implanting the medical device into a target area; wherein the membrane temperature is maintained at substantially the same temperature as the target area; wherein temperature fluctuations within the target area that approach, meet and/or exceed the volume phase transition temperature induce deswelling or relative deswelling in the membrane and temperature fluctuations within the target area that are relatively lower and/or approach and/or fall below the volume phase transition temperature induce swelling or relative swelling in the membrane.

Abstract: A plurality of devices communicate over a bus, the devices comprising a plurality of controller devices and a plurality of second devices. Each of the controller devices is responsible for assigning one or more of the addresses including at least the address of each of a respective one or more of the second devices. A controller device comprises address allocation logic configured to assign an address to each of that controller device's respective one or more second devices, by: searching for a currently unassigned address to assign to each of the respective one or more second devices, and if an unassigned address for one of those one or more second devices cannot be found, to issue a request to at least one other of the controller devices requesting that the other controller device changes one of the one or more addresses which that other controller device is responsible for assigning.

Abstract: Multiple master modules are connected to a bus, each having bus communication logic for initiating a transaction over the bus. The bus communication logic is able to detect when the bus is busy (or apparently busy), and in response will wait before initiating a transaction of its own. Further, a distributed reset sub-system is provided, comprising an instance of a reset mechanism at each of a plurality of the master modules. Each reset mechanism recognizes a timeout condition indicative of the detected busy state being due to error, and in response performs a staged reset. This reset process first attempts a local reset which resets the respective bus communication logic of its respective master module. If the local reset fails to clear the error, the staged reset process then attempts one or more further resets to reset bus communication logic of one or more other modules connected to the bus.

Abstract: The invention provides a current balancing circuit for powering a first load with a negative dynamic resistance and a second load with an essentially different negative dynamic resistance, and a transformer with such turns ratio that at least at an operating frequency impedances of the first and second windings complement the resistances of the first and the second loads, respectively, to a common value.