Patents by Inventor Alexander Aliper

Alexander Aliper has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10729703
    Abstract: The present invention provides gero-protective pharmaceutical compositions and methods, the compositions being adapted to enhance at least one of cell survival and cell metabolism in a mammalian subject, the pharmaceutical compositions include at least two of Withaferin a or its structural analogs, coumestrol, ginsenoside, quinidine, silymarin, licochalcone a, lipoic acid and apigenin, in a pharmaceutically effective amount.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: August 4, 2020
    Assignee: Insilico Medicine IP Limited
    Inventors: Aleksandrs Zavoronkovs, Alexander Aliper, Polina Mamoshina, Artem Artemov, Ivan Ozerov
  • Publication number: 20180125865
    Abstract: The present invention provides gero-protective pharmaceutical compositions and methods, the compositions being adapted to enhance at least one of cell survival and cell metabolism in a mammalian subject, the pharmaceutical compositions include at least two of Withaferin a or its structural analogs, coumestrol, ginsenoside, quinidine, silymarin, licochalcone a, lipoic acid and apigenin, in a pharmaceutically effective amount.
    Type: Application
    Filed: September 28, 2017
    Publication date: May 10, 2018
    Inventors: Aleksandrs Zavoronkovs, Alexander Aliper, Polina Mamoshina, Artem Artemov, Ivan Ozerov
  • Publication number: 20170277826
    Abstract: The present invention provides systems, methods and software for improving robustness of transcriptomic data analysis, the method including receiving control cell transcriptomic data (C) and cell transcriptomic data (S) under study for a gene, calculating a fold change ratio (fc) for the gene, repeating these steps for a plurality of genes, grouping co-expressed genes into modules, estimating gene importance factors based on a network topology, mapped from a plurality of the modules and obtaining a insilico Pathway Activation Network Decomposition Analysis (iPANDA) value, wherein the iPANDA value has a Pearson coefficient greater than a Pearson coefficient associated with another platform for manipulating the same data.
    Type: Application
    Filed: March 27, 2017
    Publication date: September 28, 2017
    Inventors: Ivan Ozerov, Ksenia Lezhnina, Aleksandrs Zavoronkovs, Alexander Aliper, Artem Artemov, Nikolay Borisov, Anton Buzdin
  • Publication number: 20170193176
    Abstract: The present invention provides systems, methods and software for predicting drug efficacy for treating a disorder in a patient, the method including providing a drug scoring database based on pathway activation strengths (PASs) for a plurality of biological pathways associated with the drug in the treatment of the disorder, thereafter providing a support vector machines (SVM) to enable SVM tuning using a floating window to transfer data from a training dataset (T) to a validation dataset (V) by interpolation along at least one PAS axis and further determining if both i) there is a positive correlation coefficient between a drug score and a clinical efficacy of the drug and ii) an area-under a curve (AUC) statistical indicator for the drug score exceeds 0.7; to provide a predictive indication if the patient is a responder or non-responder to the drug to determine whether the drug should be used in treating the patient.
    Type: Application
    Filed: December 28, 2016
    Publication date: July 6, 2017
    Inventors: Nicolay Borisov, Anton Buzdin, Aleksandrs Zavoronkovs, Alexander Aliper, Daria Allina, Olga Kovalchuk, Boris Zhestkov, Valery Shirokorad, Kirill Kashintsev, Stanislav Kostritsky
  • Publication number: 20160224739
    Abstract: The present invention provides systems, methods and software predicting a clinical outcome of a patient having breast cancer, the method including the steps of providing a drug score database (DSD) based on pathway activation strengths (PASs) for a plurality of biological pathways associated with the drug in the treatment of the disorder and comparing the pathway activation strengths of the plurality of biological pathways of the patient with the drug score database to provide a predictive indication if the patient is a responder or non-responder to the drug; and repeating these steps for a plurality of drugs thereby predicting a clinical outcome to the plurality of drugs of the patient to the breast cancer.
    Type: Application
    Filed: January 28, 2016
    Publication date: August 4, 2016
    Inventors: ALEXANDER ZHAVORONKOV, KSENIA LEZHNINA, MIKHAIL KORZINKIN, DENIS SHEPELIN, ARTEM ARTEMOV, ALEXANDER ALIPER, ANTON BUZDIN
  • Publication number: 20160224738
    Abstract: The present invention provides systems, methods and software predicting a clinical outcome of a patient having a disorder the method including the steps of providing a drug score database (DSD) based on pathway activation strengths (PASs) for a plurality of biological pathways associated with the drug in the treatment of the disorder and comparing the pathway activation strengths of the plurality of biological pathways of the patient with the drug score database to provide a predictive indication if the patient is a responder or non-responder to the drug; and repeating these steps for a plurality of drugs thereby predicting a clinical outcome to the plurality of drugs of the patient to the disorder.
    Type: Application
    Filed: January 28, 2016
    Publication date: August 4, 2016
    Inventors: ALEXANDER ZHAVORONKOV, KSENIA LEZHNINA, MIKHAIL KORZINKIN, DENIS SHEPELIN, ARTEM ARTEMOV, ALEXANDER ALIPER, ANTON BUZDIN
  • Publication number: 20160132632
    Abstract: The present invention provides systems, methods and software predicting drug efficacy for treating a disorder in a patient, the method including providing a drug score database (DSD) based on pathway manifestation strengths (PMSs) for a plurality of biological pathways associated with the drug in the treatment of the disorder and comparing the pathway manifestation strengths of the plurality of biological pathways of the patient with the drug score database to provide a predictive indication if the patient is a responder or non-responder to the drug to determine whether the drug should be used in treating the patient.
    Type: Application
    Filed: November 9, 2015
    Publication date: May 12, 2016
    Inventors: Aleksandrs Zavoronkovs, Anton Buzdin, Nikolay Borisov, Alexander Aliper