Abstract: Methods and reagents for determining treatment efficacy of a MALT1 inhibitor in a human subject are described. The method involves determining MALT1 regulated gene expression in stimulated PBMCs of a blood sample obtained from the subject. The method provides information for guiding treatment decisions for those subjects receiving a MALT1 inhibitor therapy, improves the accuracy of optimizing therapy, reduces toxicity, and/or monitors the efficacy of therapeutic treatment.

Abstract: Methods and reagents for determining treatment efficacy of a MALT1 inhibitor in a human subject are described. The method involves determining NF-?B nuclear translocation in stimulated PBMCs of a blood sample obtained from the subject. The method provides information for guiding treatment decisions for those subjects receiving a MALT1 inhibitor therapy, improves the accuracy of optimizing therapy, reduces toxicity, and/or monitors the efficacy of therapeutic treatment.

Abstract: Apparatus for operating a shaft furnace, whereby an upper section of the shaft furnace is charged with raw materials which due to gravity descend inside the furnace while the atmosphere prevailing within the shaft furnace causes part of the raw materials to melt and/or to be reduced, and in a lower section of the shaft furnace a process gas is injected so as to at least partly modify the atmosphere prevailing in the shaft furnace. The pressure and/or volume flow of the injected process gas is dynamically modulated within a time span of 40 s. Also, a shaft furnace operable by said method, thus achieving improved through-gassing.

Abstract: The present invention relates to a shaft furnace as well as a method for operating a shaft furnace. For example, the present invention relates to methods for operating a shaft furnace which include charging an upper region of the shaft furnace with raw materials; the raw materials sink in the shaft furnace under the influence of gravity and a part of the raw materials is smelted an/or at least partially reduced under the effect of the atmosphere prevailing within the shaft furnace. The methods further comprise admitting an addition gas via at least one addition opening spaced from a lower admission opening and/or discharging a shaft furnace gas via a shaft furnace gas line to provide discharge of gaseous reaction products from the interior of the shaft furnace.

Abstract: Method for operating a shaft furnace, whereby an upper section of the shaft furnace is charged with raw materials which due to gravity descend inside the furnace while the atmosphere prevailing within the shaft furnace causes part of the raw materials to melt and/or to be reduced, and in a lower section of the shaft furnace a process gas is injected so as to at least partly modify the atmosphere prevailing in the shaft furnace. The pressure and/or volume flow of the injected process gas is dynamically modulated within a time span of 40 s. Also, a shaft furnace operable by said method, thus achieving improved through-gassing.

Abstract: Method for operating a shaft furnace, whereby an upper section of the shaft furnace is charged with raw materials which due to gravity descend inside the furnace while the atmosphere prevailing within the shaft furnace causes part of the raw materials to melt and/or to be reduced, and in a lower section of the shaft furnace a process gas is injected so as to at least partly modify the atmosphere prevailing in the shaft furnace. The pressure and/or volume flow of the injected process gas is dynamically modulated within a time span of 40 s. Also, a shaft furnace operable by said method, thus achieving improved through-gassing.

Abstract: The invention relates to a method for operating a shaft furnace (10). According to said method, an upper region (14) of the shaft furnace (10) is charged with raw materials which sink in the shaft furnace (10) under the influence of gravity. Part of the raw materials is melted and/or at least partially reduced by the action of the atmosphere inside the shaft furnace (10). A treatment gas is introduced in a lower region (18) of the shaft furnace (10) by means of at least one lower admission opening (32), said treatment gas at least partially influencing the atmosphere inside the shaft furnace (10). The introduction of the lower treatment gas is dynamically modulated such that, during the modulation, the operating variables, that is pressure p1 and/or volume flow (I), are varied at least temporarily over a time span of ?40 s, especially ?20 s, preferably ?5 s and especially preferably ?1 s.

Abstract: Method for operating a shaft furnace, whereby an upper section of the shaft furnace is charged with raw materials which due to gravity descend inside the furnace while the atmosphere prevailing within the shaft furnace causes part of the raw materials to melt and/or to be reduced, and in a lower section of the shaft furnace a process gas is injected so as to at least partly modify the atmosphere prevailing in the shaft furnace. The pressure and/or volume flow of the injected process gas is dynamically modulated within a time span of 40 s. Also, a shaft furnace operable by said method, thus achieving improved through-gassing.