Abstract: An implantable stimulation electrode for use with an implantable tissue stimulator, especially a pacemaker, a defibrillator, a bone stimulator or a neurostimulator includes a metal base body, optionally one or more intermediate layers disposed on the base body and a coating covering the base body and, optionally, intermediate layers in order to increase tissue compatibility. The coating should prevent tissue irritations after implantation and more particularly increase the stimulus threshold associated therewith, have very high biocompatibility and also has an anti-inflammatory effect. An increase in tissue compatibility is achieved by virtue of the fact that the coating has a polysaccharide layer made of hyaluronic acid and/or hyaluronic acid derivatives.

Abstract: A stent comprising a basic stent body, at least one anchor group on the surface of the basic stent body, and at least one biomolecule which is bound to the at least one anchor group, the anchor group being the same or different and selected from the group of compounds with the general formula (I) (R2O)2(O)P-L-(CH2)x-M-R1 ??(I) in which R1 represents —COOH, —OH, —SH, —NH2, benzophenone or benzophenone derivatives, R2 represents hydrogen, —CH2CH3 or —CH3, L represents a single bond or —O—, M represents a single bond or —(CH2—CH2—O)y, x represents an integer from 1 to 25, y represents an integer from 1 to 25 and the biomolecule or biomolecules are selected as the same or different from the group consisting of compounds which promote the attachment of the endothelial progenitor cells to the stent surface.

Abstract: An implant made of a biocorrodible metallic material and having a coating or cavity filling comprising gelatin.

Abstract: A stent made of a biocorrodible metallic material having a coating or cavity filling comprising a diblock or triblock copolymer made of (i) a poly(D,L-lactide-co-glycolide) block and (ii) a polyethylene glycol block.

Abstract: A method for producing a composite made of oligonucleotides or polynucleotides and hydrophobic biodegradable polymers. The method comprises the following steps: (i) producing an aqueous solution of a polyethylene glycol having a mean molecular weight in the range from 600 to 8,000 g/mole; (ii) adding an aqueous, possibly buffered solution of oligonucleotides or polynucleotides to the aqueous solution from step (i); iii) freezing the aqueous solution from step (ii) and subsequently freeze-drying the frozen solution to obtain a freeze-dried substrate; (iv) providing a solution of the hydrophobic biodegradable polymer in an organic solvent; (v) adding the substrate obtained according to step (iii) to the solution of the polymer; and (vi) removing the organic solvent to obtain the composite. Also disclosed is a composite produced by the method.

Abstract: An x-ray marker for medical implants made of a biocorrodible metallic material, wherein the x-ray marker composite comprises 1-40 weight parts of a carrier matrix having a melting point greater than or equal to 43° C., which comprises 90 weight-percent or more triglycerides; and 60-99 weight parts of a radiopaque marker component, which is embedded in the carrier matrix.

Abstract: An implant made of a biocorrodible metallic material having a coating made of an organosilicon compound.

Abstract: A coated implant and a method of use of cholesterol or a cholesterol ester. The implant has a coating which contains one or more components selected from the group of cholesterol and cholesterol esters.

Abstract: The invention concerns methods of coating stents and stents produced in accordance therewith. The object of the invention is to provide methods of coating stents with a polysaccharide layer which has improved adhesion capacity on the substrate surface of the implant, and to afford correspondingly functionalized stents. That is achieved inter alia by covalent bonding of a non-crosslinked hyaluronic acid to a substrate surface of the stent with the formation of hyaluronic acid layer and crosslinking of the hyaluronic acid layer.

Abstract: The invention relates to a coating system for implants comprising a metal base body, which is optionally covered with one or several intermediate layers. Said coating system comprises a coating which is disposed thereon in order to increase tissue compatibility. The coating prevents tissue irritations after implantation has an extremely high biocompatibility and has an anti-inflammatory effect. This is achieved by virtue of the fact that the coating comprises a polysaccharide layer made of a) chitosane and b) hyaluronic acid and/or hyaluronic acid derivatives.

Abstract: The invention concerns methods of coating stents and stents produced in accordance therewith. The object of the invention is to provide methods of coating stents with a polysaccharide layer which has improved adhesion capacity on the substrate surface of the implant, and to afford correspondingly functionalized stents. That is achieved inter alia by covalent bonding of a non-crosslinked hyaluronic acid to a substrate surface of the stent with the formation of hyaluronic acid layer and crosslinking of the hyaluronic acid layer.