Patents by Inventor Alexander Borisovich Tuzikov

Alexander Borisovich Tuzikov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180344805
    Abstract: The invention relates to novel glycolipid compounds and pharmaceutical compositions comprising said glycolipids and to processes for preparing said glycolipids. The invention also relates to said glycolipids for use in treating tumours and methods of treating tumours using said glycolipids.
    Type: Application
    Filed: November 15, 2015
    Publication date: December 6, 2018
    Inventors: Graham GRIFFITHS, Stephen SHAW, Nicolai Vladimirovich BOVIN, Alexander Borisovich TUZIKOV, Elena Yurievna KORCHAGINA, Stephen HENRY
  • Patent number: 10040823
    Abstract: Functional-lipid constructs of the structure F-S-L are disclosed, wherein F comprises a tyrosine or histidine residue, S is a spacer covalently linking F to L and L is a lipid. The functional residue may be iodinated and used to radiolabel a biological entity with 1251 and the iodinated constructs are used in a non-invasive method of monitoring the distribution of a biological entity in vivo.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: August 7, 2018
    Assignee: KODE BIOTECH LIMITED
    Inventors: Nikolai Vladimirovich Bovin, Stephen Henry, Elena Yurievna Korchagina, Igor Leonidovich Rodionov, Alexander Borisovich Tuzikov
  • Patent number: 9821080
    Abstract: Non-invasive method of monitoring by radioactivity bioscanning the distribution of a biological entity in a subject in vivo by administering to the subject a radioiodinated form of the biological entity. The radioiodinated form is prepared by contacting an aqueous suspension of the biological entity with a radioiodinated construct of the structure F-S-L where F comprises a radioiodinated tyrosine moiety, S is a spacer covalently linking F to L, and L is a lipid.
    Type: Grant
    Filed: February 9, 2012
    Date of Patent: November 21, 2017
    Inventors: Nikolai Vladimirovich Bovin, Stephen Henry, Elena Yurievna Korchagina, Igor Leonidovich Rodionov, Alexander Borisovich Tuzikov
  • Publication number: 20170320914
    Abstract: Water dispersible, multivalent ligand-lipid constructs that spontaneously and stably incorporate into membranes are disclosed.
    Type: Application
    Filed: November 23, 2015
    Publication date: November 9, 2017
    Inventors: Nicolai Vladimirovich BOVIN, Stephen Micheal HENRY, Elena KORCHAGINA, Igor Leonidovich RODIONOV, Alexander Borisovich TUZIKOV
  • Patent number: 9802981
    Abstract: The invention relates to methods for effecting qualitative and quantitative changes in the functional moieties expressed at the surface of cells and multi-cellular structures, and functional lipid constructs for use in such methods. In particular, the invention relates to functional lipid constructs and their use in diagnostic and therapeutic applications, including serodiagnosis, where the functional moiety is a carbohydrate, peptide, chemically reactive group, conjugator or fluorophore.
    Type: Grant
    Filed: February 4, 2014
    Date of Patent: October 31, 2017
    Assignee: Kode Biotech Limited
    Inventors: Nicolai Vladimirovich Bovin, Stephen Micheal Henry, Igor Leonidovich Rodionov, Cristina-Simona Weinberg, Alexander Borisovich Tuzikov
  • Publication number: 20170240597
    Abstract: Functional-lipid constructs of the structure F-S-L are disclosed, wherein F comprises a tyrosine or histidine residue, S is a spacer covalently linking F to L and L is a lipid. The functional residue may be iodinated and used to radiolabel a biological entity with 1251 and the iodinated constructs are used in a non-invasive method of monitoring the distribution of a biological entity in vivo.
    Type: Application
    Filed: April 18, 2017
    Publication date: August 24, 2017
    Inventors: Nikolai Vladimirovich Bovin, Stephen Henry, Elena Yurievna Korchagina, Igor Leonidovich Rodionov, Alexander Borisovich Tuzikov
  • Publication number: 20170218027
    Abstract: The invention relates to functional lipid constructs and their use in diagnostic and therapeutic applications, including serodiagnosis, where the functional moiety is carbohydrate, peptide, chemically reactive group, conjugator or fluorophore.
    Type: Application
    Filed: November 14, 2016
    Publication date: August 3, 2017
    Inventors: Nicolai Vladimirovich Bovin, Stephen Micheal Henry, Igor Leonidovich Rodionov, Critsina-Simona Weinberg, Alexander Borisovich Tuzikov
  • Patent number: 9221879
    Abstract: Multiligand constructs and intermediate multivalent constructs for use in their preparation are described. The multiligand constructs have utility in diagnostic and therapeutic applications.
    Type: Grant
    Filed: January 23, 2014
    Date of Patent: December 29, 2015
    Assignee: SEMIOTIK LLC
    Inventors: Nikolai Vladimirovich Bovin, Alexander Alexandrovich Chinarev, Alexander Borisovich Tuzikov
  • Publication number: 20140350217
    Abstract: The invention relates to methods for effecting qualitative and quantitative changes in the functional moieties expressed at the surface of cells and multi-cellular structures, and functional lipid constructs for use in such methods. In particular, the invention relates to functional lipid constructs and their use in diagnostic and therapeutic applications, including serodiagnosis, where the functional moiety is a carbohydrate, peptide, chemically reactive group, conjugator or fluorophore.
    Type: Application
    Filed: February 4, 2014
    Publication date: November 27, 2014
    Applicant: KODE Biotech Limited
    Inventors: Nicolai Vladimirovich Bovin, Stephen Micheal Henry, Igor Leonidovich Rodionov, Cristina-Simona Weinberg, Alexander Borisovich Tuzikov
  • Publication number: 20140161723
    Abstract: Functional-lipid constructs of the structure F-S-L are disclosed, wherein F comprises a tyrosine or histidine residue, S is a spacer covalently linking F to L and L is a lipid. The functional residue may be iodinated and used to radiolabel a biological entity with 1251 and the iodinated constructs are used in a non-invasive method of monitoring the distribution of a biological entity in vivo.
    Type: Application
    Filed: February 9, 2012
    Publication date: June 12, 2014
    Inventors: Nikolai Vladimirovich Bovin, Stephen Henry, Elena Yurievna Korchagina, Igor Leonidovich Rodionov, Alexander Borisovich Tuzikov
  • Publication number: 20140135477
    Abstract: Multiligand constructs and intermediate multivalent constructs for use in their preparation are described. The multiligand constructs have utility in diagnostic and therapeutic applications.
    Type: Application
    Filed: January 23, 2014
    Publication date: May 15, 2014
    Applicant: SEMIOTIK LLC
    Inventors: Nikolai Vladimirovich Bovin, Alexander Alexandrovich Chinarev, Alexander Borisovich Tuzikov
  • Patent number: 8674061
    Abstract: Multiligand constructs and intermediate multivalent constructs for use in their preparation. The multiligand constructs have utility in diagnostic and therapeutic applications.
    Type: Grant
    Filed: October 13, 2008
    Date of Patent: March 18, 2014
    Assignee: Smiotik LLC
    Inventors: Nikolai Vladimirovich Bovin, Alexander Alexandrovich Chinarev, Alexander Borisovich Tuzikov
  • Patent number: 8669084
    Abstract: The invention relates to methods for effecting qualitative and quantitative changes in the functional moieties expressed at the surface of cells and multi-cellular structures, and functional lipid constructs for use in such methods. In particular, the invention relates to functional lipid constructs and their use in diagnostic and therapeutic applications, including serodiagnosis, where the functional moiety is a carbohydrate, peptide, chemically reactive group, conjugator or fluorophore.
    Type: Grant
    Filed: October 13, 2008
    Date of Patent: March 11, 2014
    Assignee: Kode Biotech Limited
    Inventors: Nicolai Vladimirovich Bovin, Stephen Micheal Henry, Igor Leonidovich Rodionov, Cristina-Simona Weinberg, Alexander Borisovich Tuzikov
  • Publication number: 20120021430
    Abstract: The invention relates to methods for effecting qualitative and quantitative changes in the functional moieties expressed at the surface of cells and multi-cellular structures, and functional lipid constructs for use in such methods. In particular, the invention relates to functional lipid constructs and their use in diagnostic and therapeutic applications, including serodiagnosis, where the functional moiety is a carbohydrate, peptide, chemically reactive group, conjugator or fluorophore.
    Type: Application
    Filed: October 13, 2008
    Publication date: January 26, 2012
    Inventors: Nicolai Vladimirovich Bovin, Stephen Micheal Henry, Igor Leonidovich Rodionov, Cristina-Simona Weinberg, Alexander Borisovich Tuzikov
  • Publication number: 20110257081
    Abstract: Multiligand constructs and intermediate multivalent constructs for use in their preparation are described. The multiligand constructs have utility in diagnostic and therapeutic applications.
    Type: Application
    Filed: October 13, 2008
    Publication date: October 20, 2011
    Inventors: Nikolai Vladimirovich Bovin, Alexander Alexandrovich Chinarev, Alexander Borisovich Tuzikov