Patents by Inventor Alexander Bridges

Alexander Bridges has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITORS OF EGFR, KRAS, BRAF, AND OTHER TARGETS AND USE OF THE SAME
    Publication number: 20230098205
    Abstract: Provided herein are compounds that are useful in treating cancer.
    Type: Application
    Filed: March 5, 2021
    Publication date: March 30, 2023
    Inventors: Mukesh K. Nyati, Alexander Bridges, Jason Christopher Rech, Brennan Taylor Watch
  • INHIBITORS OF EGFR, KRAS, BRAF, AND OTHER TARGETS AND USE OF THE SAME
    Publication number: 20230097789
    Abstract: Provided herein are compounds that are useful in treating cancer.
    Type: Application
    Filed: March 5, 2021
    Publication date: March 30, 2023
    Inventors: Mukesh K. Nyati, Theodore S. Lawrence, Christopher Whitehead, Jason Christopher Rech, Brennan Taylor Watch, Alexander Bridges
  • Location-based video gaming with anchor points
    Patent number: 11241624
    Abstract: A mobile video game uses real world anchor points in providing for video game play which includes virtual elements. The real world anchor points may be specified in terms of a geographic coordinate system, and game play may be based on mobile device presence at or about the anchor points.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: February 8, 2022
    Assignee: Activision Publishing, Inc.
    Inventors: Joshua Alexander Bridge, Robert Frederick Ford, Eunice Lee, Nathan Lutz, Michal Tadeusz Madej, Paul Reiche, III
  • HISTONE DEACETYLASE INHIBITORS
    Publication number: 20210009519
    Abstract: Provided herein are compounds and methods for inhibiting histone deacetylase (“HDAC”) enzymes (e.g., HDAC1, HDAC2, and HDAC3).
    Type: Application
    Filed: September 22, 2020
    Publication date: January 14, 2021
    Inventors: Shripad Bhagwat, Gregory Luedtke, Alexander Bridges
  • Histone deacetylase inhibitors
    Patent number: 10851058
    Abstract: Provided herein are compounds and methods for inhibiting histone deacetylase (“HDAC”) enzymes (e.g., HDAC1, HDAC2, and HDAC3).
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: December 1, 2020
    Assignee: BIOMARIN PHARMACEUTICAL INC.
    Inventors: Shripad Bhagwat, Gregory Luedtke, Alexander Bridges
  • LOCATION-BASED VIDEO GAMING WITH ANCHOR POINTS
    Publication number: 20200206629
    Abstract: A mobile video game uses real world anchor points in providing for video game play which includes virtual elements. The real world anchor points may be specified in terms of a geographic coordinate system, and game play may be based on mobile device presence at or about the anchor points.
    Type: Application
    Filed: December 20, 2019
    Publication date: July 2, 2020
    Inventors: Joshua Alexander Bridge, Robert Frederick Ford, Eunice Lee, Nathan Lutz, Michal Tadeusz Madej, Paul Reiche, III
  • METHODS FOR THE TREATMENT OF ERECTILE DYSFUNCTION USING FISPEMIFENE
    Publication number: 20200060991
    Abstract: A method of treatment of erectile dysfunction (ED) comprises the step of administering fispemifene to a subject in need thereof in an amount effective to raise the subject's testosterone level. Fispemifene may be used in combination with a PDE-5 inhibitor in individuals who have failed to respond sufficiently to conventional ED treatment. Methods are also disclosed of treating ED by administering clomifene, enclomifene, ospemifene, toremifene and mixtures thereof in combination with a PDE-5 inhibitor.
    Type: Application
    Filed: November 1, 2019
    Publication date: February 27, 2020
    Inventors: Robert L. Zerbe, Alexander Bridges, Risto Lammintausta, Rochelle Hanley, Stuart Dombey
  • HISTONE DEACETYLASE INHIBITORS
    Publication number: 20190382342
    Abstract: Provided herein are compounds and methods for inhibiting histone deacetylase (“HDAC”) enzymes (e.g., HDAC1, HDAC2, and HDAC3).
    Type: Application
    Filed: July 1, 2016
    Publication date: December 19, 2019
    Inventors: Shripad Bhagwat, Gregory Luedtke, Alexander Bridges
  • Methods for the treatment of erectile dysfunction using fispemifene
    Patent number: 10500166
    Abstract: A method of treatment of erectile dysfunction (ED) comprises the step of administering fispemifene to a subject in need thereof in an amount effective to raise the subject's testosterone level. Fispemifene may be used in combination with a PDE-5 inhibitor in individuals who have failed to respond sufficiently to conventional ED treatment. Methods are also disclosed of treating ED by administering clomifene, enclomifene, ospemifene, toremifene and mixtures thereof in combination with a PDE-5 inhibitor.
    Type: Grant
    Filed: March 21, 2013
    Date of Patent: December 10, 2019
    Assignee: QUATRX PHARMACEUTICALS
    Inventors: Robert L. Zerbe, Alexander Bridges, Risto Lammintausta, Rochelle Hanley, Stuart Dombey
  • Histone deacetylase inhibitors
    Patent number: 10308608
    Abstract: Provided herein are compounds and methods for inhibiting histone deacetylase (“HDAC”) enzymes (e.g., HDAC1, HDAC2, and HDAC3).
    Type: Grant
    Filed: July 27, 2018
    Date of Patent: June 4, 2019
    Assignee: BIOMARIN PHARMACEUTICAL INC.
    Inventors: Shripad Bhagwat, Gregory Luedtke, Alexander Bridges
  • HISTONE DEACETYLASE INHIBITORS
    Publication number: 20180370915
    Abstract: Provided herein are compounds and methods for inhibiting histone deacetylase (“HDAC”) enzymes (e.g., HDAC1, HDAC2, and HDAC3).
    Type: Application
    Filed: July 27, 2018
    Publication date: December 27, 2018
    Inventors: Shripad Bhagwat, Gregory Luedtke, Alexander Bridges
  • COMPOSITIONS FOR TREATING OR PREVENTING OBESITY AND INSULIN RESISTANCE DISORDERS
    Publication number: 20170216272
    Abstract: Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.
    Type: Application
    Filed: February 3, 2017
    Publication date: August 3, 2017
    Applicants: President and Fellows of Harvard College, The General Hospital Corporation d/b/a Massachusetts General Hospital
    Inventors: David A. Sinclair, Maria Alexander-Bridges
  • Compositions for treating obesity and insulin resistance disorders
    Patent number: 9597347
    Abstract: Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.
    Type: Grant
    Filed: August 15, 2014
    Date of Patent: March 21, 2017
    Assignees: President and Fellows of Harvard College, The General Hospital Corporation
    Inventors: David A. Sinclair, Maria Alexander-Bridges
  • Methods of stimulating fat mobilization using a polymer conjugated polyphenol
    Patent number: 9272049
    Abstract: Provided herein are compositions and methods for preventing and treating diseases and risk factors associated with metabolic syndrome by targeting the RGD-binding site of selected intra- and extracellular proteins. Exemplary compositions include RGD-polyphenol conjugates via an ester linkage; polyphenol polymer conjugated to RGD analogs or mimetics; and RGD polymer conjugates linked to polyphenol.
    Type: Grant
    Filed: June 8, 2011
    Date of Patent: March 1, 2016
    Assignee: NANOPHARMACEUTICALS LLC
    Inventors: Maria Alexander-Bridges, Shaker A. Mousa, Paul J. Davis
  • COMPOSITIONS FOR TREATING OR PREVENTING OBESITY AND INSULIN RESISTANCE DISORDERS
    Publication number: 20150133396
    Abstract: Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.
    Type: Application
    Filed: August 15, 2014
    Publication date: May 14, 2015
    Applicants: President and Fellows of Harvard College, The General Hospital Corporation d/b/a Massachusetts General Hospital
    Inventors: David A. Sinclair, Maria Alexander-Bridges
  • Compositions for treating obesity and insulin resistance disorders
    Patent number: 8846724
    Abstract: Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.
    Type: Grant
    Filed: July 27, 2011
    Date of Patent: September 30, 2014
    Assignees: President and Fellows of Harvard College, The General Hospital Corporation
    Inventors: David A. Sinclair, Maria Alexander-Bridges
  • METHODS FOR THE TREATMENT OF ERECTILE DYSFUNCTION USING FISPEMIFENE
    Publication number: 20130217696
    Abstract: A method of treatment of erectile dysfunction (ED) comprises the step of administering fispemifene to a subject in need thereof in an amount effective to raise the subject's testosterone level. Fispemifene may be used in combination with a PDE-5 inhibitor in individuals who have failed to respond sufficiently to conventional ED treatment. Methods are also disclosed of treating ED by administering clomifene, enclomifene, ospemifene, toremifene and mixtures thereof in combination with a PDE-5 inhibitor.
    Type: Application
    Filed: March 21, 2013
    Publication date: August 22, 2013
    Applicant: QuatRX Pharmaceuticals Company
    Inventors: Robert L. Zerbe, Alexander Bridges, Risto Lammintausta, Rochelle Hanley, Stuart Dombey
  • RGD-BINDING COMPOUNDS AND METHODS OF USE
    Publication number: 20120258069
    Abstract: Provided herein are compositions and methods for preventing and treating diseases and risk factors associated with metabolic syndrome by targeting the RGD-binding site of selected intra- and extracellular proteins. Exemplary compositions include RGD-polyphenol conjugates via an ester linkage; polyphenol polymer conjugated to RGD analogs or mimetics; and RGD polymer conjugates linked to polyphenol.
    Type: Application
    Filed: June 8, 2011
    Publication date: October 11, 2012
    Inventors: Maria Alexander-Bridges, Shaker A. Mousa, Paul J. Davis
  • Method for reducing the weight of a subject or inhibiting weight gain in a subject
    Patent number: 8242171
    Abstract: Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.
    Type: Grant
    Filed: January 7, 2010
    Date of Patent: August 14, 2012
    Assignees: President and Fellows of Harvard College, The General Hospital Corporation
    Inventors: David A. Sinclair, Maria Alexander-Bridges
  • COMPOSITIONS FOR TREATING OR PREVENTING OBESITY AND INSULIN RESISTANCE DISORDERS
    Publication number: 20120029065
    Abstract: Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.
    Type: Application
    Filed: July 27, 2011
    Publication date: February 2, 2012
    Applicants: The General Hospital Corporation d/b/a Massachusetts General Hospital, President and Fellows of Harvard College
    Inventors: David A. Sinclair, Maria Alexander-Bridges