Abstract: The present invention relates to a metering pump comprising (i) a diaphragm return device comprising tie rod and (ii) a diaphragm assembly comprising a mechanically driven elastic diaphragm having a flexible region between the clamping surface, which serves to seal the delivery chamber, at the periphery of the diaphragm and a diaphragm core which serves for force transmission, pressure generation and for connection to the tie rod, characterized in that the diaphragm assembly and the tie rod are connected by means of a hook coupling, or a plug-in coupling, or a clamping connection.

Abstract: A metering pump for conveying fluids, with a metering head in which a metering chamber is arranged, a displacement element that can be moved back and forth between a first position and a second position on a movement axis, and a drive that rotates around a rotation axis, whereby a rotation movement of the drive around the rotation axis is converted into an oscillating movement of a connecting rod by a gear arrangement.

Abstract: The present invention relates to a metering pump comprising (i) a diaphragm return device comprising tie rod and (ii) a diaphragm assembly comprising a mechanically driven elastic diaphragm having a flexible region between the clamping surface, which serves to seal the delivery chamber, at the periphery of the diaphragm and a diaphragm core which serves for force transmission, pressure generation and for connection to the tie rod, characterized in that the diaphragm assembly and the tie rod are connected by means of a hook coupling, or a plug-in coupling, or a clamping connection.

Abstract: A diaphragm unit for a diaphragm pump includes a diaphragm core and a multi-layer pump diaphragm connected to the diaphragm core. The pump diaphragm has a fluid-impermeable working layer which comes into contact with a fluid to be delivered, and a fluid-impermeable safety layer. A sealed volume for receiving fluid passing through the working layer is arranged between the working layer and the safety layer. A first clamping region of the diaphragm forms a ring which annularly surrounds the diaphragm core. To detect a rupture of the working diaphragm layer, at least one element of a sensor is provided within the ring formed by the first clamping region for detecting fluid which penetrates into the sealed volume.

Abstract: The present invention concerns a diaphragm unit (1) for a diaphragm pump comprising a diaphragm core (2) having a receiving means (3) for a thrust rod (4, 4?, 4?) of a pump drive, and a multi-layer pump diaphragm (5) connected to the diaphragm core (2), wherein the pump diaphragm (5) has a fluid-impermeable working diaphragm layer (6) which in operation of the diaphragm pump comes into contact with a fluid to be delivered by the diaphragm pump, and a fluid-impermeable safety diaphragm layer (7), a sealed volume (12) for receiving a fluid passing through the working diaphragm layer, that is arranged between the working diaphragm layer (6) and the safety diaphragm layer (7), and a first clamping region (9) with which the pump diaphragm (5) can be received in a receiving means of the diaphragm pump, wherein the first clamping region (9) forms a ring which annularly surrounds the diaphragm core (2).

Abstract: The present invention relates to a positive displacement pump having a delivery chamber, which is connected to a discharge connection and a suction connection, characterized in that the surface of the delivery chamber is configured in the form of an at least partially microstructured surface. The at least partially microstructured surface has a multiplicity of ribs and channels located therebetween, these running in a direction along the direction of flow of the delivery medium. As a result of the surface being structured, the situation where gas bubbles stick is reliably prevented and the harmful gas volume is considerably reduced.

Abstract: A displacement pump includes a delivery chamber, connected to a pressure connection and a suction connection. A displacement element determines the volume of the delivery chamber and can be moved back and forth between a first position, in which the delivery chamber has a smaller volume, and a second position, in which the delivery chamber has a larger volume. The pressure connection is connected to the delivery chamber by a pressure valve and the suction connection is connected to the delivery chamber by a suction valve. The displacement pump is easy and economical to produce and simultaneously reliably provides a degassing function, whereby downtimes can be reduced and the reliability of the delivery process can be increased. With the pressure valve closed, a backflow channel connects the delivery chamber and pressure connection, through which medium can enter the delivery chamber and/or gas can escape from the delivery chamber.

Abstract: A pressure retention valve including a housing having an inlet passage and an outlet passage that can be connected together and a separating diaphragm subdividing the housing into two portions, wherein, in operation of the valve, a first portion conveys fluid and a second portion is fluid-free. The valve further includes a valve seat defining an end of the inlet passage, arranged in the fluid-conveying portion of the housing, and has a first sealing surface, a shut-off body which is arranged movably in the fluid-conveying portion of the housing and has a second sealing surface, and a spring element having a spring force, which is arranged in the fluid-free portion of the pressure retention valve.

Abstract: The present invention relates to a displacement pump with a delivery chamber, which is connected to a pressure connection and a suction connection, a displacement element determining the volume of the delivery chamber, said displacement element being able to be moved back and forth between a first position, in which the delivery chamber has a smaller volume, and a second position, in which the delivery chamber has a larger volume, wherein the pressure connection is connected to the delivery chamber by a pressure valve and the suction connection is connected to the delivery chamber by a suction valve.

Abstract: A pressure retention valve including a housing having an inlet passage and an outlet passage that can be connected together and a separating diaphragm subdividing the housing into two portions, wherein, in operation of the valve, a first portion conveys fluid and a second portion is fluid-free. The valve further includes a valve seat defining an end of the inlet passage, arranged in the fluid-conveying portion of the housing, and has a first sealing surface, a shut-off body which is arranged movably in the fluid-conveying portion of the housing and has a second sealing surface, and a spring element having a spring force, which is arranged in the fluid-free portion of the pressure retention valve.

Abstract: A separation element of a multi-layer structure for pressure compensation including: at least two mutually superposed flexible, fluid-tight material layers; at least one spacer element which is arranged between the material layers and holds them at a spacing relative to each other, wherein the at least one spacer element is such that the space between the flexible, fluid-tight material layers is at least partly adapted for fluid to flow therethrough, and at an edge region of the multi-layer structure the separation element has a sensor region (S) which is in a communication with remaining space between the flexible, fluid-tight material layers through which fluid can flow, wherein within the sensor region, the flexible, fluid-tight material layers are designed so that, by virtue of an inflow of fluid between them, an increase of pressure causes an increase in the spacing between the material layers relative to each other.

Abstract: A separation element of a multi-layer structure for pressure compensation including: at least two mutually superposed flexible, fluid-tight material layers; at least one spacer element which is arranged between the material layers and holds them at a spacing relative to each other, wherein the at least one spacer element is such that the space between the flexible, fluid-tight material layers is at least partly adapted for fluid to flow therethrough, and at an edge region of the multi-layer structure the separation element has a sensor region (S) which is in a communication with remaining space between the flexible, fluid-tight material layers through which fluid can flow, wherein within the sensor region, the flexible, fluid-tight material layers are designed so that, by virtue of an inflow of fluid between them, an increase of pressure causes an increase in the spacing between the material layers relative to each other.

Abstract: A safety diaphragm for a diaphragm pump, which makes it possible to detect a rupture of the diaphragm during operation or when at a standstill. The diaphragm has at least two diaphragm layers (1, 2) arranged lying one on top of the other The diaphragm has a clamping region (E) for fixing the diaphragm in a pump and has an adjacent operational region (A). The diaphragm layer (1, 2) are connected to each other so that they are sealed against penetration of liquid and/or gas between the diaphragm layers (1, 2). The diaphragm, in one section of the clamping region (E), has a sensor region (S) where the diaphragm layers (1, 2) are formed so that, in the case of an increase in pressure between the diaphragm layers (1, 2), the layers in sensor region (S) deform more easily than in the other sections of the diaphragm.

Abstract: A flat sealing ring (1) for producing a fluid-tight coupling of two surfaces which are to be sealed against one another by means of a contact force, the ring (1) having an elastically deformable base ring (2), wherein a stiffening ring (3, 3′, 3″) is provided at at least one of the inner circumferential edge of the base ring (2) or the outer circumferential edge of the base ring (2), wherein the stiffening ring, at least perpendicularly to the ring plane, has a lesser deformability, or greater firmness, than the base ring (2), and wherein the height of the stiffening ring perpendicularly to the ring plane is less than the greatest height of the base ring (2) perpendicularly to the ring plane.

Abstract: A safety diaphragm for a diaphragm pump, which makes it possible to detect a rupture of the diaphragm during operation or when at a standstill. The diaphragm has at least two diaphragm layers (1, 2) arranged lying one on top of the other, and preferably has an essentially circular periphery. The at least two diaphragm layers (1, 2) each has opposing inner and outer surfaces and a peripheral edge and are arranged so that the inner surfaces of the diaphragm layers are adjacent each other. The diaphragm has a clamping region (E), from the peripheral edge towards a center, running in a peripheral direction for fixing the diaphragm in a pump and has an adjacent operational region (A) from the clamping region (E) toward the center. The diaphragm layers (1, 2) are connected to each other so that they are sealed against penetration of liquid and/or gas between the diaphragm layers and so that there is atmospheric or subatmospheric pressure between the diaphragm layers (1, 2).

Abstract: The present invention provides a vector plasmid capable of efficient tumor necrosis factor (TNF) production, a process capable of efficient TNF production in a host transformed with said plasmid and a composition containing the TNF produced by said process.The novel plasmid of the present invention is characterized by having inserted therein a DNA fragment that has a phage-derived promoter region upstream of a structural gene for TNF and in which a DNA fragment containing an E. coli gene-derived transcription termination coding base sequence (terminator) is joined immediately downstream of a base sequence coding for the termination of translation of said structural gene.