Patents by Inventor Alexander Chan

Alexander Chan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210300954
    Abstract: The invention relates to the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. In another aspect, the invention relates to compounds of formula (II): processes for making these compounds, and the use thereof in the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. The invention also relates to methods of synthesis of oligomers, including but not limited to oligopeptides, oligosaccharides and oligonucleotides, particularly oligoribonucleotides and also oligodeoxyribonucleotides, in solution systems, and ionic tag linkers for use in methods provided herein.
    Type: Application
    Filed: May 21, 2021
    Publication date: September 30, 2021
    Inventors: Masad J. Damha, Matthew Hassler, Tak-Hang Chan, Mallikarjuna Reddy Nandyala, Robert Alexander Donga
  • Patent number: 11124778
    Abstract: A method for biosynthesis of polymer precursors, including, adipic acid, 1,6-hexanediol, 6-hydroxyhexanoic and 6-aminocaproic acids from carboxylic acids is provided. A method for biosynthesis of adipic acid from six-carbon dicarboxylic acids having ?, ?-enoate reductase activity by treatment with an enzyme is provided. The biocatalytic conversion of aliphatic and hydroxycarboxylic acids to corresponding aldehydes, alcohols, and amines using novel carboxylate reductases, aldehyde reductases, and aminotransferases is described. Also provided are genetically engineered microorganisms for use in the biosynthetic processes.
    Type: Grant
    Filed: July 4, 2016
    Date of Patent: September 21, 2021
    Assignee: The Governing Council of The University of Toronto
    Inventors: Alexander Yakunin, Anna Khusnutdinova, Jeong Chan Joo, Radhakrishnan Mahadevan
  • Publication number: 20210287898
    Abstract: Method for selectively oxidizing the dielectric surface of a substrate surface comprising a dielectric surface and a metal surface are discussed. Method for cleaning a substrate surface comprising a dielectric surface and a metal surface are also discussed. The disclosed methods oxidize the dielectric surface and/or clean the substrate surface using a plasma generated from hydrogen gas and oxygen gas. The disclosed method may be performed in a single step without the use of separate competing oxidation and reduction reactions. The disclosed methods may be performed at a constant temperature and/or within a single processing chamber.
    Type: Application
    Filed: March 10, 2021
    Publication date: September 16, 2021
    Applicant: Applied Materials, Inc
    Inventors: Bencherki Mebarki, Joung Joo Lee, Yi Xu, Yu Lei, Xianmin Tang, Kelvin Chan, Alexander Jansen, Philip A. Kraus
  • Patent number: 11120264
    Abstract: Various embodiments of the invention pertain to an augmented reality interface for facilitating identification of an arriving vehicle and/or a passenger that improve upon some or all of the above-described deficiencies. According to some embodiments of the invention, a mobile device may be used by a passenger to scan scenery. The mobile device may determine whether and where a requested vehicle is located and display an indicator of the requested vehicle on the mobile device. Similarly, a mobile device may be used by a driver to scan scenery. The mobile device may determine whether and where a passenger is located and display an indicator of the requesting passenger on the mobile device.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: September 14, 2021
    Assignee: Apple Inc.
    Inventors: Alexander J. O'Connell, Justin M. Strawn, Ryan D. Shelby, Sunny Chan, Tadayasu Sasada, Vincent P. Arroyo
  • Patent number: 11096606
    Abstract: A method and wireless sensor device for determining body postures and activities. In one aspect, a method includes receiving sensor data. The method also includes detecting and classifying a body transition of a body based on the sensor data. The method also includes detecting if there is activity of the body based on the sensor data. If there is activity, the method also includes classifying the activity. If there is no activity, the method also includes classifying a rest position of the body based on the sensor data and based on a previous body transition.
    Type: Grant
    Filed: June 8, 2018
    Date of Patent: August 24, 2021
    Assignee: Vital Connect, Inc.
    Inventors: Alexander Chan, Nima Ferdosi, Ravi Narasimhan
  • Publication number: 20200378951
    Abstract: The present invention provides a method of determining the cytotoxic effect of an effector molecule or cell on a target cell presenting a heterologous peptide comprising: (a) incubating said effector molecule or cell with said target cell, wherein said target cell is immobilised on a substrate comprising at least one pair of electrodes; and (b) determining the impedance during and/or after step a) wherein a decrease in impedance is indicative of target cell death.
    Type: Application
    Filed: November 23, 2017
    Publication date: December 3, 2020
    Inventors: Damian Marshall, Alexander Chan, Adeyemi Afuwape
  • Patent number: 10719574
    Abstract: A method and system for calibrating a wireless sensor device are disclosed. In a first aspect, the method comprises determining a vertical calibration vector and determining a rotation matrix using the vertical calibration vector to line up native axes of the wireless sensor device with body axes. In a second aspect, a wireless sensor device comprises a processor and a memory device coupled to the processor, wherein the memory device includes an application that, when executed by the processor, causes the processor to determine a vertical calibration vector and to determine a rotation matrix using the vertical calibration vector to line up native axes of the wireless sensor device with body axes.
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: July 21, 2020
    Assignee: Vital Connect, Inc.
    Inventors: Alexander Chan, Nima Ferdosi, Ravi Narasimhan
  • Patent number: 10687757
    Abstract: A method and system for determining psychological acute stress are disclosed. In a first aspect, the method comprises detecting a physiological signal using a wireless sensor device, determining a stress feature using a normalized heart rate and a plurality of heart rate variability (HRV) features, wherein the normalized heart rate and the plurality of heart rate variability features are calculated using the detected physiological signal, and determining a stress level using the stress feature to determine the psychological acute stress. In a second aspect, the system comprises a wireless sensor device that includes a processor and a memory device coupled to the processor, wherein the memory device stores an application which, when executed by the processor, causes the wireless sensor device to carry out the steps of the method.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: June 23, 2020
    Assignee: Vital Connect, Inc.
    Inventors: Alexander Chan, Ravi Narasimhan, Nandakumar Selvaraj, Toai Doan
  • Patent number: 10617325
    Abstract: A method and system for measuring respiratory rate are disclosed. In a first aspect, the method comprises measuring at least one respiration signal and filtering the respiration signal using a lowpass filter. The method includes peak-picking the respiration signal to determine the respiratory rate and determining a quality metric of the respiratory rate. In a second aspect, the system comprises a wireless sensor device coupled to a user via at least one electrode, wherein the wireless sensor device includes a processor and a memory device coupled to the processor, wherein the memory device stores an application which, when executed by the processor, causes the processor to carry out the steps of the method.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: April 14, 2020
    Assignee: Vital Connect, Inc.
    Inventors: Alexander Chan, Ravi Narasimhan
  • Publication number: 20200046231
    Abstract: A method and system for contextual heart rate monitoring are disclosed. In a first aspect, the method comprises calculating a heart rate using a detected ECG signal and detecting an activity level. In a second aspect, the system comprises a wireless sensor device coupled to a user via at least one electrode, wherein the wireless sensor device includes a processor and a memory device coupled to the processor, wherein the memory device stores an application which, when executed by the processor, causes the processor to calculate a heart rate using a detected ECG signal and to detect an activity level.
    Type: Application
    Filed: October 18, 2019
    Publication date: February 13, 2020
    Inventors: Nima FERDOSI, Ravi NARASIMHAN, ALEXANDER CHAN
  • Patent number: 10448849
    Abstract: A method and system for contextual heart rate monitoring are disclosed. In a first aspect, the method comprises calculating a heart rate using a detected ECG signal and detecting an activity level. In a second aspect, the system comprises a wireless sensor device coupled to a user via at least one electrode, wherein the wireless sensor device includes a processor and a memory device coupled to the processor, wherein the memory device stores an application which, when executed by the processor, causes the processor to calculate a heart rate using a detected ECG signal and to detect an activity level.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: October 22, 2019
    Assignee: Vital Connect, Inc.
    Inventors: Nima Ferdosi, Ravi Narasimhan, Alexander Chan
  • Patent number: 10433781
    Abstract: A method and system for measuring psychological stress disclosed. In a first aspect, the method comprises determining R-R intervals from an electrocardiogram (ECG) to calculate a standard deviation of the R-R intervals (SDNN) and determining a stress feature (SF) using the SDNN. In response to reaching a threshold, the method includes performing adaptation to update a probability mass function (PMF). The method includes determining a stress level (SL) using the SF and the updated PMF to continuously measure the psychological stress. In a second aspect, the system comprises a wireless sensor device coupled to a user via at least one electrode, wherein the wireless sensor device includes a processor and a memory device coupled to the processor, wherein the memory device stores an application which, when executed by the processor, causes the processor to carry out the steps of the method.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: October 8, 2019
    Assignee: VITAL CONNECT, INC.
    Inventors: Alexander Chan, Ravi Narasimhan
  • Patent number: 10422814
    Abstract: A method and system for fall detection using machine learning are disclosed. The method comprises detecting at least one signal by a wireless sensor device and calculating a plurality of features from the at least one detected signal. The method includes training a machine learning unit of the wireless sensor device using the features to create a fall classification and a non-fall classification for the fall detection. The system includes a sensor to detect at least one signal, a processor coupled to the sensor, and a memory device coupled to the processor, wherein the memory device includes an application that, when executed by the processor, causes the processor to calculate a plurality of features from the at least one detected signal and to train a machine learning unit of the wireless sensor device using the features to create a fall classification and a non-fall classification for the fall detection.
    Type: Grant
    Filed: July 18, 2013
    Date of Patent: September 24, 2019
    Assignee: Vital Connect, Inc.
    Inventors: Alexander Chan, Nima Ferdosi, Ravi Narasimhan
  • Patent number: 10383562
    Abstract: A method and system for measuring psychological stress disclosed. In a first aspect, the method comprises determining R-R intervals from an electrocardiogram (ECG) to calculate a standard deviation of the R-R intervals (SDNN) and determining a stress feature (SF) using the SDNN. In response to reaching a threshold, the method includes performing adaptation to update a probability mass function (PMF). The method includes determining a stress level (SL) using the SF and the updated PMF to continuously measure the psychological stress. In a second aspect, the system comprises a wireless sensor device coupled to a user via at least one electrode, wherein the wireless sensor device includes a processor and a memory device coupled to the processor, wherein the memory device stores an application which, when executed by the processor, causes the processor to carry out the steps of the method.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: August 20, 2019
    Assignee: Vital Connect, Inc.
    Inventors: Alexander Chan, Ravi Narasimhan
  • Patent number: 10324109
    Abstract: A method and wireless sensor device for determining a time period a person is in bed. In one aspect, a method includes utilizing a wireless sensor device to obtain a plurality of acceleration samples in relation to at least one axis associated with a person's body over a predetermined time window. The method also includes calculating a polar angle for each acceleration sample within the predetermined time window. The method also includes calculating a fraction of an amount of time within the predetermined time window that the polar angle is greater than an angle threshold that indicates that the person is lying down, where if the fraction is greater than a predetermined threshold, the predetermined time window is marked as a period the person is lying down.
    Type: Grant
    Filed: September 15, 2016
    Date of Patent: June 18, 2019
    Assignee: VITAL CONNECT, INC.
    Inventors: Alexander Chan, Ravi Narasimhan
  • Patent number: 10317427
    Abstract: A method and system for calibrating a wireless sensor device are disclosed. In a first aspect, the method comprises determining a vertical calibration vector and determining a rotation matrix using the vertical calibration vector to line up native axes of the wireless sensor device with body axes. In a second aspect, a wireless sensor device comprises a processor and a memory device coupled to the processor, wherein the memory device includes an application that, when executed by the processor, causes the processor to determine a vertical calibration vector and to determine a rotation matrix using the vertical calibration vector to line up native axes of the wireless sensor device with body axes.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: June 11, 2019
    Assignee: VITAL CONNECT, INC.
    Inventors: Alexander Chan, Nima Ferdosi, Ravi Narasimhan
  • Patent number: 10312570
    Abstract: A long-distance radio frequency anti-metal identification tag is provided. When a bottom surface of an insulating spacer plate is attached to the surface of a metal object and an electronic tag reading device is used to read a radio frequency identification chip on a second antenna. A resonant cavity is formed between a slot of a first antenna and the surface of the metal object through the isolation of the insulating spacer plate, such that the second antenna located at the position of the resonant cavity resonates with an electromagnetic wave signal reflected on the surface of the metal object by the first antenna. The electromagnetic wave signal is transmitted to the radio frequency identification chip, or the feedback signal of the radio frequency identification chip is transmitted out. The overall UHF electronic tag is resistant to a metal interference and has the performance of long-distance reading.
    Type: Grant
    Filed: September 1, 2017
    Date of Patent: June 4, 2019
    Assignee: Read Tag Technology Corp.
    Inventors: Chi Ju Wu, Shirl Mei Chang, Alexander Chan, Chin Hsien Ting, Hsi Jui Chan
  • Patent number: 10213146
    Abstract: A method and system for measuring psychological stress disclosed. In a first aspect, the method comprises determining R-R intervals from an electrocardiogram (ECG) to calculate a standard deviation of the R-R intervals (SDNN) and determining a stress feature (SF) using the SDNN. In response to reaching a threshold, the method includes performing adaptation to update a probability mass function (PMF). The method includes determining a stress level (SL) using the SF and the updated PMF to continuously measure the psychological stress. In a second aspect, the system comprises a wireless sensor device coupled to a user via at least one electrode, wherein the wireless sensor device includes a processor and a memory device coupled to the processor, wherein the memory device stores an application which, when executed by the processor, causes the processor to carry out the steps of the method.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: February 26, 2019
    Assignee: VITAL CONNECT, INC.
    Inventors: Arshan Aga, Alexander Chan, Ravi Narasimhan
  • Publication number: 20180338708
    Abstract: A method and wireless sensor device for determining step count is disclosed. In one aspect, a method includes receiving sensor data. The method includes detecting if there is activity of the body based on the sensor data. If there is activity, the method also includes classifying the activity and determining step count based on classification of the activity.
    Type: Application
    Filed: June 8, 2018
    Publication date: November 29, 2018
    Inventors: Alexander CHAN, Nima FERDOSI, Ravi NARASIMHAN
  • Publication number: 20180310879
    Abstract: A method and system for determining psychological acute stress are disclosed. In a first aspect, the method comprises detecting a physiological signal using a wireless sensor device, determining a stress feature using a normalized heart rate and a plurality of heart rate variability (HRV) features, wherein the normalized heart rate and the plurality of heart rate variability features are calculated using the detected physiological signal, and determining a stress level using the stress feature to determine the psychological acute stress. In a second aspect, the system comprises a wireless sensor device that includes a processor and a memory device coupled to the processor, wherein the memory device stores an application which, when executed by the processor, causes the wireless sensor device to carry out the steps of the method.
    Type: Application
    Filed: May 22, 2018
    Publication date: November 1, 2018
    Inventors: Alexander CHAN, Ravi NARASIMHAN, Nandakumar SELVARAJ, Toai DOAN