Patents by Inventor Alexander CHOU
Alexander CHOU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240115314Abstract: Provided herein are systems, devices, and methods for performing a medical procedure on a patient. The system comprises an ablation catheter comprising a shaft, at least one therapeutic element positioned on the shaft, and one or more tissue-contact sensing components configured to provide a contact signal related to the level of contact between the at least one therapeutic element and tissue. The system further comprises: an energy delivery unit configured to deliver ablative energy to the at least one therapeutic element to create a lesion in target tissue, and to provide an energy delivery data; a force module configured to receive the contact signal and provide contact data; and a processing unit configured to determine an ablation index based on both the energy delivery data and the contact data. The ablation index can represent the status of the lesion being created.Type: ApplicationFiled: February 17, 2022Publication date: April 11, 2024Inventors: Ahmad FALAHATPISHEH, Steven YON, Xinwei SHI, Haizhe ZHANG, Derrick CHOU, Timothy CORVI, Graydon Earnest BEATTY, Daniel WELSH, Alexander HIGGINS, Marcus JULIAN, R. Maxwell FLAHERTY, J. Christopher FLAHERTY
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Patent number: 11913049Abstract: An engineered microorganism(s) with novel pathways for the conversion of short-chain hydrocarbons to fuels and chemicals (e.g. carboxylic acids, alcohols, hydrocarbons, and their alpha-, beta-, and omega-functionalized derivatives) is described. Key to this approach is the use of hydrocarbon activation enzymes able to overcome the high stability and low reactivity of hydrocarbon compounds through the cleavage of an inert C—H bond. Oxygen-dependent or oxygen-independent activation enzymes can be exploited for this purpose, which when combined with appropriate pathways for the conversion of activated hydrocarbons to key metabolic intermediates, enables the generation of product precursors that can subsequently be converted to desired compounds through established pathways. These novel engineered microorganism(s) provide a route for the production of fuels and chemicals from short chain hydrocarbons such as methane, ethane, propane, butane, and pentane.Type: GrantFiled: May 19, 2020Date of Patent: February 27, 2024Inventors: Ramon Gonzalez, James Clomburg, Alexander Chou
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Publication number: 20230332191Abstract: Many biotechnologically relevant organisms cannot utilize cheap and abundant one carbon feedstocks, e.g. CO2, CO, formaldehyde, methanol, and methane, for growth and instead prefer complex feedstocks such as sugars. Disclosed herein is a system that enables organisms to consume one carbon molecules for growth and maintenance via a formyl-CoA elongation pathway. Utilization of one carbon feedstocks can replace the use of sugar as the primary means of cultivating organisms in biotechnological applications. This has the potential to be more cost effective and avoid the controversial use of food as feedstocks. Intermediates of the formyl-CoA elongation pathway may be also be converted to desired chemical products.Type: ApplicationFiled: August 26, 2021Publication date: October 19, 2023Inventors: Ramon GONZALEZ, Alexander CHOU, James CLOMBURG, Fayin ZHU, Seung Hwan LEE
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Publication number: 20220112477Abstract: An engineered microbe that contains a designed platform for the conversion of one-carbon substrates to chemical products is described. The designed platform embodies a new metabolic architecture that consolidates carbon fixation, central metabolism, and product synthesis into a single pathway. This is made possible by the key finding that 2-hydroxyacyl-CoA lyase, an enzyme in the ?-oxidation pathway, is capable of catalyzing the C—C bond formation between formyl-CoA and aldehydes of different chain lengths, allowing for the elongation of the carbon backbone of said aldehyde by one-carbon units. These novel microbes present an opportunity for the production of chemicals from single-carbon feedstocks such as carbon dioxide, carbon monoxide, formate, formaldehyde, methanol or methane.Type: ApplicationFiled: October 26, 2021Publication date: April 14, 2022Inventors: Ramon Gonzalez, Alexander Chou, James Clomburg
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Patent number: 11186834Abstract: An engineered microbe that contains a designed platform for the conversion of one-carbon substrates to chemical products is described. The designed platform embodies a new metabolic architecture that consolidates carbon fixation, central metabolism, and product synthesis into a single pathway. This is made possible by the key finding that 2-hydroxyacyl-CoA lyase, an enzyme in the ?-oxidation pathway, is capable of catalyzing the C—C bond formation between formyl-CoA and aldehydes of different chain lengths, allowing for the elongation of the carbon backbone of said aldehyde by one-carbon units. These novel microbes present an opportunity for the production of chemicals from single-carbon feedstocks such as carbon dioxide, carbon monoxide, formate, formaldehyde, methanol or methane.Type: GrantFiled: October 29, 2015Date of Patent: November 30, 2021Inventors: Ramon Gonzalez, Alexander Chou, James Clomburg
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Publication number: 20200347423Abstract: An engineered microorganism(s) with novel pathways for the conversion of short-chain hydrocarbons to fuels and chemicals (e.g. carboxylic acids, alcohols, hydrocarbons, and their alpha-, beta-, and omega-functionalized derivatives) is described. Key to this approach is the use of hydrocarbon activation enzymes able to overcome the high stability and low reactivity of hydrocarbon compounds through the cleavage of an inert C—H bond. Oxygen-dependent or oxygen-independent activation enzymes can be exploited for this purpose, which when combined with appropriate pathways for the conversion of activated hydrocarbons to key metabolic intermediates, enables the generation of product precursors that can subsequently be converted to desired compounds through established pathways. These novel engineered microorganism(s) provide a route for the production of fuels and chemicals from short chain hydrocarbons such as methane, ethane, propane, butane, and pentane.Type: ApplicationFiled: May 19, 2020Publication date: November 5, 2020Inventors: Ramon Gonzalez, James Clomburg, Alexander Chou
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Publication number: 20190100741Abstract: An engineered microbe that contains a designed platform for the conversion of one-carbon substrates to chemical products is described. The designed platform embodies a new metabolic architecture that consolidates carbon fixation, central metabolism, and product synthesis into a single pathway. This is made possible by the key finding that 2-hydroxyacyl-CoA lyase, an enzyme in the ?-oxidation pathway, is capable of catalyzing the C—C bond formation between formyl-CoA and aldehydes of different chain lengths, allowing for the elongation of the carbon backbone of said aldehyde by one-carbon units. These novel microbes present an opportunity for the production of chemicals from single-carbon feedstocks such as carbon dioxide, carbon monoxide, formate, formaldehyde, methanol or methane.Type: ApplicationFiled: October 29, 2015Publication date: April 4, 2019Inventors: Ramon GONZALEZ, Alexander CHOU, James CLOMBURG
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Patent number: 6312963Abstract: A method provides estimations of physical interconnect process parameter values in a process for manufacturing integrated circuits. The method includes fabricating test structures each providing a value of a measurable quantity corresponding to a value within a range of values of the physical interconnect process parameters. In some embodiments, the measured value is used to derive the values of the physical interconnect process parameters, either by a numerical method using a field solver, or by a closed-form solution. The values of physical interconnect process parameters involving physical dimensions are also obtained by measuring photomicrographs obtained using a scanning electron microscope from cross sections of test structures. In some embodiments, a family of test structures corresponding to a range of conductor widths and a range of spacings between conductors are measured.Type: GrantFiled: February 4, 1999Date of Patent: November 6, 2001Assignee: Sequence Design, Inc.Inventors: Shih-Tsun Alexander Chou, Keh-Jeng Chang, Robert G. Mathews
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Patent number: 6291254Abstract: A method provides estimations of physical interconnect process parameter values in a process for manufacturing integrated circuits. The method includes fabricating test structures each providing a value of a measurable quantity corresponding to a value within a range of values of the physical interconnect process parameters. In some embodiments, the measured value is used to derive the values of the physical interconnect process parameters, either by a numerical method using a field solver, or by a closed-form solution. The values of physical interconnect process parameters involving physical dimensions are also obtained by measuring photomicrographs obtained using a scanning electron microscope from cross sections of test structures. In some embodiments, a family of test structures corresponding to a range of conductor widths and a range of spacings between conductors are measured.Type: GrantFiled: February 4, 1999Date of Patent: September 18, 2001Assignee: Sequence Design, Inc.Inventors: Shih-tsun Alexander Chou, Keh-Jeng Chang, Robert G. Mathews
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Patent number: 6057171Abstract: A method provides estimations of physical interconnect process parameter values in a process for manufacturing integrated circuits. The method includes fabricating test structures each providing a value of a measurable quantity corresponding to a value within a range of values of the physical interconnect process parameters. In some embodiments, the measured value is used to derive the values of the physical interconnect process parameters, either by a numerical method using a field solver, or by a closed-form solution. The values of physical interconnect process parameters involving physical dimensions are also obtained by measuring photomicrographs obtained using a scanning electron microscope from cross sections of test structures. In some embodiments, a family of test structures corresponding to a range of conductor widths and a range of spacings between conductors are measured.Type: GrantFiled: September 25, 1997Date of Patent: May 2, 2000Assignee: Frequency Technology, Inc.Inventors: Shih-tsun Alexander Chou, Keh-Jeng Chang, Robert G. Mathews