Abstract: The invention relates to novel bispecific antigen binding molecules, comprising at least two antigen binding domains capable of specific binding to OX40 and a particular antigen binding domain capable of specific binding to Fibroblast Activation Protein (FAP), and to methods of producing these molecules and to methods of using the same.

Abstract: A component for a projection exposure apparatus for semiconductor lithography, comprises an optical element and an actuator, which are force-fittingly connected to each other. The actuator at least locally deforms the optical element. The actuator can be configured to minimize the loss in rigidity at the peripheries delimiting the actuator on the imaging quality. A method for designing a component of projection exposure apparatus is provided.

Abstract: An intervertebral implant with a support portion (1.1) and a proximal contact portion (1.3) adjoined thereto in the longitudinal direction, is better adapted, as an intervertebral implant, to the contours of the lower and upper sides of the vertebrae that are spaced apart by the implant. An upper side (1.6) and a lower side (1.7) of the implant are configured symmetrically relative to a horizontal center plane (L-Q). In particular a height of the support portion between the transition (U) thereof to the contact portion (1.3) and a distal end face (1.2) facing away from the contact portion (1.3) are greater than the height at the transition (U) and at the distal end face (1.2).

Abstract: An intervertebral implant with a support portion (1.1) and a proximal contact portion (1.3) adjoined thereto in the longitudinal direction, is better adapted, as an intervertebral implant, to the contours of the lower and upper sides of the vertebrae that are spaced apart by the implant. An upper side (1.6) and a lower side (1.7) of the implant are configured symmetrically relative to a horizontal center plane (L-Q). In particular a height of the support portion between the transition (U) thereof to the contact portion (1.3) and a distal end face (1.2) facing away from the contact portion (1.3) are greater than the height at the transition (U) and at the distal end face (1.2).

Abstract: A device (1) for fixating a rod (10) on a bone with a tulip, with a pedicle screw (2) and with a tightening screw (5). The rod clamp (6) is pivotable to the tightening screw and can follow transverse motions of the rod (10). This increases the stability of the entire structure, particularly in the application in spine surgery.

Abstract: A device (1) for fixating a rod (10) on a bone with a tulip, with a pedicle screw (2) and with a tightening screw (5). The rod clamp (6) is pivotable to the tightening screw and can follow transverse motions of the rod (10). This increases the stability of the entire structure, particularly in the application in spine surgery.

Abstract: A device has a work piece spindle for accommodating a bevel gear work piece, a tool spindle for accommodating a grinding wheel having an abrasive surface, and a plurality of drives for machining the bevel gear work piece. During machining of the bevel gear work piece, the grinding wheel rotates about the rotational axis of the tool spindle and engages the bevel gear work piece to remove material. The rotation is superimposed with an eccentric movement such that the grinding wheel only engages the bevel gear work piece at n contact regions of the abrasive surface. The device is configured to allow adjustment of the eccentric movement after a first machining phase and to specify m contact regions of the abrasive surface in a further machining pase, wherein the m contact regions do not overlap with the n contact regions.

Abstract: An apparatus for decorating a fireplace is provided. The apparatus includes a fireplace insert at least one insert plate. The insert is configured to exist within the environment of the fireplace. The insert creatively illustrates a decorative theme such as a small scale scene within the fireplace. The insert can include a plurality of plates providing a three dimensional scene within the fireplace.

Abstract: A method of chip-removal machining a tooth gap of a work piece includes executing a first substantially linear plunging movement of the cutting tool along a first plunge vector and machining a region of the work piece near a tooth head of a first tooth flank of the tooth. A substantially transverse movement of the tool along a transverse vector is then executed to machine a region of the work piece near a tooth head of the second tooth flank of the tooth. A second plunging movement of the cutting tool along a vector path is then executed, to an end point of the second plunging movement that lies at a position of the work piece corresponding to the slot depth of the tooth gap to be fabricated. The cutting tool is rotated about an axis of rotation thereof during execution of these steps.

Abstract: A device has a work piece spindle for accommodating a bevel gear work piece, a tool spindle for accommodating a grinding wheel having an abrasive surface, and a plurality of drives for machining the bevel gear work piece. During machining of the bevel gear work piece, the grinding wheel rotates about the rotational axis of the tool spindle and engages the bevel gear work piece to remove material. The rotation is superimposed with an eccentric movement such that the grinding wheel only engages the bevel gear work piece at n contact regions of the abrasive surface. The device is configured to allow adjustment of the eccentric movement after a first machining phase and to specify m contact regions of the abrasive surface in a further machining pase, wherein the m contact regions do not overlap with the n contact regions.

Abstract: A method of chip-removal machining a tooth gap of a work piece includes executing a first substantially linear plunging movement of the cutting tool along a first plunge vector and machining a region of the work piece near a tooth head of a first tooth flank of the tooth. A substantially transverse movement of the tool along a transverse vector is then executed to machine a region of the work piece near a tooth head of the second tooth flank of the tooth. A second plunging movement of the cutting tool along a vector path is then executed, to an end point of the second plunging movement that lies at a position of the work piece corresponding to the slot depth of the tooth gap to be fabricated. The cutting tool is rotated about an axis of rotation thereof during execution of these steps.

Abstract: Bar cutter head (20) for receiving multiple bar cutters of a first bar cutter set, the bar cutter head (20) having n receptacle openings (25.1-25.6) for receiving n bar cutters of the first bar cutter set, which are all situated along a first concentric cutter head nominal circle having a first cutter head nominal radius (r1). A first spiral-toothed bevel gear (11) can be milled in the single-indexing method in this configuration. The bar cutter head (20) additionally has m receptacle openings (26.1 -26.6) for receiving m bar cutters of a second bar cutter set, which are all situated along a second concentric cutter head nominal circle having a second cutter head nominal radius (r2). A second spiral-toothed bevel gear can be milled in the configuration having the m bar cutters. It is thus a universally-usable cutter head (20).

Abstract: Method for the chip-removing machining of the tooth flanks of a gear wheel having n teeth and n tooth gaps on a multiaxis grinding machine. A grinding disc which may be dressed is used for the machining and one of the n tooth gaps after another is machined using this grinding disc in the single indexing method. The grinding disc plunges into each of the n tooth gaps up to a predefined plunging depth (T1). If it is a freshly dressed grinding disc, the grinding disc is plunged using a predefined first restraint in relation to the normal predefined plunging depth into m of the n tooth gaps at the beginning of the machining of the gear wheel, to pre-machine these m tooth gaps (for this purpose: m=1, 2, or 3 and m<n). The remaining n?m tooth gaps are subsequently machined using the predefined plunging depth (T1).

Abstract: Bar cutter head (20) for receiving multiple bar cutters of a first bar cutter set, the bar cutter head (20) having n receptacle openings (25.1-25.6) for receiving n bar cutters of the first bar cutter set, which are all situated along a first concentric cutter head nominal circle having a first cutter head nominal radius (r1). A first spiral-toothed bevel gear (11) can be milled in the single-indexing method in this configuration. The bar cutter head (20) additionally has m receptacle openings (26.1-26.6) for receiving m bar cutters of a second bar cutter set, which are all situated along a second concentric cutter head nominal circle having a second cutter head nominal radius (r2). A second spiral-toothed bevel gear can be milled in the configuration having the m bar cutters. It is thus a universally-usable cutter head (20).