Abstract: The present invention relates to compounds of Formula I that function as inhibitors of BCL6 (B-cell lymphoma 6) activity: wherein X1, X2, R1, R2 and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which BCL6 activity is implicated.

Abstract: A processor with instruction storage configured to store processor instructions, data storage configured to store processor data representing an array, the array including plural data elements, a controller, and an instruction pipeline. The instruction pipeline includes: a load stage circuit configured to load an array element from the data storage, a compare stage circuit configured to compare the array element to a reference value, a store stage circuit configured to store a set of results that includes a result of the comparison of the array element to the reference value, and a loop hit detect stage circuit configured to determine whether any of the set of results is associated with a hit on the reference value.

Abstract: Power tool devices described herein include a motor, an actuator configured to be actuated by a user, a plurality of power switching elements configured to drive the motor, a gate driver coupled to the plurality of power switching elements and configured to control the plurality of power switching elements, a first printed circuit board (PCB), an antenna, and a combined chip. The combined chip is located on the first PCB and is coupled to the actuator, the antenna, and the gate driver. The combined chip includes a memory and an electronic processor configured to determine that the actuator has been actuated, and provide, in response to determining that the actuator has been actuated, a signal to the gate driver, control the signal based on the motor position information, wirelessly transmit power tool device information to an external device, and wirelessly receive configuration information from the external device via the antenna.

Abstract: A device for retaining a bicycle chain on a sprocket includes a base plate defining a plurality of fastener openings centered on an origin. A center of each of the plurality of fastener openings is disposed at a first radial distance from the origin. The origin defines an axis extending substantially orthogonally from a plane defined by two lines extending from the origin and at least two centers of the centers of the plurality of fastener openings. A first guard is secured to the base plate and includes a first guard retaining surface including a first curved surface defined by a second radial distance from the axis that is greater than the first radial distance and a first guard guiding surface having a first end adjacent the first guard retaining surface and a second end distal from the first end. The first end is disposed at the second radial distance from the axis. The second end is disposed at a third radial distance from the axis. The third radial distance is greater than the second radial distance.

Abstract: The present invention relates to compounds that function as inhibitors of BCL6 (B-cell lymphoma 6) activity. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which BCL6 activity is implicated.

Abstract: A system for classifying structured medical data, with each item of structured medical data, the system comprising a processing module that parses items of structured medical data to retrieve values of respective fields of the one or more items of structured medical data, the one or more retrieved values representing a set of medical attributes; a classification module that selects a classifier based at least one of the attributes in the set and applies the classifier to the set of attributes to classify one or more items of structured medical data into a particular risk profile; a user interface that renders one or more controls for input data that confirms one or more of the risk factors of the risk profile; and a transmitter to transmit to a remote medical device, an alert that specifies confirmation of the one or more of the risk factors.

Abstract: A device for retaining a bicycle chain on a sprocket includes a base plate defining a plurality of fastener openings centered on an origin. A center of each of the plurality of fastener openings is disposed at a first radial distance from the origin. The origin defines an axis extending substantially orthogonally from a plane defined by two lines extending from the origin and at least two centers of the centers of the plurality of fastener openings. A first guard is secured to the base plate and includes a first guard retaining surface including a first curved surface defined by a second radial distance from the axis that is greater than the first radial distance and a first guard guiding surface having a first end adjacent the first guard retaining surface and a second end distal from the first end. The first end is disposed at the second radial distance from the axis. The second end is disposed at a third radial distance from the axis. The third radial distance is greater than the second radial distance.

Abstract: The present invention relates to compounds of formula I that function as inhibitors of BCL6 (B-cell lymphoma 6) activity: wherein X1, X2, R1, R2, R30, R31 and Ring A are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which BCL6 activity is implicated.

Abstract: A system for classifying structured medical data, with each item of structured medical data, the system comprising a processing module that parses items of structured medical data to retrieve values of respective fields of the one or more items of structured medical data, the one or more retrieved values representing a set of medical attributes; a classification module that selects a classifier based at least one of the attributes in the set and applies the classifier to the set of attributes to classify one or more items of structured medical data into a particular risk profile; a user interface that renders one or more controls for input data that confirms one or more of the risk factors of the risk profile; and a transmitter to transmit to a remote medical device, an alert that specifies confirmation of the one or more of the risk factors.

Abstract: A mobile robot having a removable wheel-drive assembly, comprising a mobile base having a chassis and a first wheel well member with a flange. There is a removable wheel drive assembly with a mounting bracket. There is a motor drive unit disposed on the mounting bracket and a wheel/tire connected to the motor drive unit via an axle. There is a second wheel well member on the mounting bracket and positioned between the motor drive unit and the wheel. The second wheel well member includes a central section having an aperture through which the axle passes and a top surface. The top surface of the central section of the second wheel well member engages with the flange of the first wheel well member of the mobile base.

Abstract: Method and system for providing secured access to services rendered by digital voice assistants are disclosed. In an example, the method includes generating, by the digital voice assistant in a set-up mode, hierarchical access levels for a plurality of services rendered by the digital voice assistant, based on an input from a super user. The method further includes generating, by the digital voice assistant in an operational mode and upon receiving a voice command from a user for a first time, a unique voice directive corresponding to the voice command. The unique voice directive comprises language tags and voice tags extracted from the voice command. The method further includes assigning an access level from among the hierarchical access levels to the unique voice directive and rendering a service from among the plurality of services based on the access level and the voice directive.

Abstract: An implant delivery instrument includes a housing with a main body section that defines a passage therethrough from a front end of the main body section to a back end of the main body section. The passage receives an obturator through an opening at the back end, and also receives an implant device. Movement of the obturator through the passage pushes the implant device through a discharge opening at the front end and through an incision into a subdermal pocket of a patient. The housing includes a tab connected to and projecting from the front end of the main body section. The tab has a blunt dissection tip for maintaining the incision in an open state without creating or enlarging the incision, and the tab is configured to surround the implant device moving through the discharge opening along only one side of the implant device.

Abstract: One embodiment of a skateboarding balance device where an elongated structure (10) has four straps (16L, 16R) disposed thereunder said structure. This pad (10) is composed of flexible material. The straps (16L, 16R) provide for a method of securely attaching said pad (10) to a skateboard (SK1) by means of velcro (20L, 18R). The straps are made of material with elasticity.

Abstract: A sand control screen assembly includes a base pipe having openings through its thickness, and a mesh layer having mesh material sections coupled to safe edges, or connectors, for connecting sections together. The safe edges include areas of thinning to provide flex joints that yield when exposed to high stresses. The mesh layer may be a drainage layer or a filter medium of the sand control screen assembly.

Abstract: A device for retaining a bicycle chain on a sprocket includes a base plate defining a plurality of fastener openings centered on an origin. A center of each of the plurality of fastener openings is disposed at a first radial distance from the origin. The origin defines an axis extending substantially orthogonally from a plane defined by two lines extending from the origin and at least two centers of the centers of the plurality of fastener openings. A first guard is secured to the base plate and includes a first guard retaining surface including a first curved surface defined by a second radial distance from the axis that is greater than the first radial distance and a first guard guiding surface having a first end adjacent the first guard retaining surface and a second end distal from the first end. The first end is disposed at the second radial distance from the axis. The second end is disposed at a third radial distance from the axis. The third radial distance is greater than the second radial distance.