Abstract: Disclosed herein are methods of disrupting cell-to-cell communication. An exemplary method comprises transmitting one or more microwave signals to a communication molecule located in an environment having a plurality of cells. The one or more microwave signals can comprise a first microwave signal and a second microwave signal. The first microwave signal can have a first frequency corresponding to frequency of a first peak in a microwave spectrum associated with rotational modes of the communication molecule. The second microwave signal can have a second frequency corresponding to a frequency of a second peak in the microwave spectrum associated with the rotational modes of the communication molecule.

Abstract: A mobile robot having a removable wheel-drive assembly, comprising a mobile base having a chassis and a first wheel well member with a flange. There is a removable wheel drive assembly with a mounting bracket. There is a motor drive unit disposed on the mounting bracket and a wheel/tire connected to the motor drive unit via an axle. There is a second wheel well member on the mounting bracket and positioned between the motor drive unit and the wheel. The second wheel well member includes a central section having an aperture through which the axle passes and a top surface. The top surface of the central section of the second wheel well member engages with the flange of the first wheel well member of the mobile base.

Abstract: A media terminal includes two integrated currency devices, each device providing at least one feature/operation that is similar to or is the same as the other device. Two independent sessions to each device are made and presented to a transaction application of the terminal as a single aggregated session. When the transaction application issues a command through the single aggregated session, a decision is made that is transparent to the application as to which device should process the command on behalf of the application and the command is issued to the selected device over the corresponding independent session. Results or notifications provided by the selected device are aggregated and provided to the application over the single aggregated session. In an embodiment, the two integrated currency devices are different types of devices from one another.

Abstract: An intelligent legal document generation and review system and associated methods are disclosed. The system comprises one or more processors coupled to memory storing instructions to provide a user interface for receiving user input, execute a natural language processing subsystem to extract relevant information, access a legal rules database, store document templates, and execute an AI algorithm. The AI algorithm retrieves a relevant template based on user input and extracted information, populates the template to generate a customized legal document, and stores the document. An attorney feedback loop allows attorneys to provide feedback that the AI algorithm learns from to improve document generation. The AI algorithm collaborates with attorneys to revise and finalize documents based on the feedback. The system streamlines document preparation, automates complex tasks, and provides expert guidance to help users adhere to legal requirements across jurisdictions.

Abstract: Various embodiments of the present disclosure relate to conditional branch instructions to support software pipelining techniques. In an example embodiment, a system including instruction fetch circuitry, decoder circuitry, and conditional branch circuitry is provided. The instruction fetch circuitry is configured to fetch a conditional branch instruction from memory and provide the instruction to the decoder circuitry. The instruction includes an iteration count and multiple branch destinations. The branch destinations include two or more branch destinations corresponding to conditions against which the conditional branch circuitry evaluates the iteration count.

Abstract: A system to estimate consequences of an explosion includes a scenario generator to generate a scenario based on user input and scenario parameters; an explosive device model generator to generate an explosive device model based on the user input and explosive device parameters; a propagation of hazards modeler to model propagation of hazards into the scenario based on the user input and hazard parameters; an injury modeler to model injuries corresponding to modeling propagation of hazards into the scenario based on injury parameters; and an iteration and output generator to iterate by using additional iterative subsets of the parameters to generate the scenario, generate the explosive device model, model propagation of hazards, and model injuries, until parameter spaces of the parameters are covered. The iteration and output generator generates an injury record based injury outcomes from the modeling of injuries corresponding to the iterating.

Abstract: A cloud security control platform and method enforces security controls across multiple cloud environments, services and disparate teams while providing a frictionless “Permissions on Demand” mechanism for approvals and exceptions. In contrast to the prior art, security is evaluated on a permission by permission basis, with the default being that all permissions are denied and then only given to a particular identity on an as-needed basis. This approach reduces the security risks associated with the vast capabilities available in Public Cloud environments and permits an organization that uses the platform to grant access, approve exceptions and delegate approvals with the appropriate compliance.

Abstract: A media terminal includes two integrated currency devices, each device providing at least one feature/operation that is similar to or is the same as the other device. Two independent sessions to each device are made and presented to a transaction application of the terminal as a single aggregated session. When the transaction application issues a command through the single aggregated session, a decision is made that is transparent to the application as to which device should process the command on behalf of the application and the command is issued to the selected device over the corresponding independent session. Results or notifications provided by the selected device are aggregated and provided to the application over the single aggregated session. In an embodiment, the two integrated currency devices are different types of devices from one another.

Abstract: The present invention relates to compounds of Formula I that function as inhibitors of BCL6 (B-cell lymphoma 6) activity: wherein X1, X2, R1, R2 and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which BCL6 activity is implicated.

Abstract: The present invention relates to compounds of Formula I that function as inhibitors of BCL6 (B-cell lymphoma 6) activity: wherein X1, X2, R1, R2 and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which BCL6 activity is implicated.

Abstract: A device for retaining a bicycle chain on a sprocket includes a base plate defining a plurality of fastener openings centered on an origin. A center of each of the plurality of fastener openings is disposed at a first radial distance from the origin. The origin defines an axis extending substantially orthogonally from a plane defined by two lines extending from the origin and at least two centers of the centers of the plurality of fastener openings. A first guard is secured to the base plate and includes a first guard retaining surface including a first curved surface defined by a second radial distance from the axis that is greater than the first radial distance and a first guard guiding surface having a first end adjacent the first guard retaining surface and a second end distal from the first end. The first end is disposed at the second radial distance from the axis. The second end is disposed at a third radial distance from the axis. The third radial distance is greater than the second radial distance.

Abstract: The present invention relates to compounds that function as inhibitors of BCL6 (B-cell lymphoma 6) activity. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which BCL6 activity is implicated.

Abstract: A system for classifying structured medical data, with each item of structured medical data, the system comprising a processing module that parses items of structured medical data to retrieve values of respective fields of the one or more items of structured medical data, the one or more retrieved values representing a set of medical attributes; a classification module that selects a classifier based at least one of the attributes in the set and applies the classifier to the set of attributes to classify one or more items of structured medical data into a particular risk profile; a user interface that renders one or more controls for input data that confirms one or more of the risk factors of the risk profile; and a transmitter to transmit to a remote medical device, an alert that specifies confirmation of the one or more of the risk factors.

Abstract: A device for retaining a bicycle chain on a sprocket includes a base plate defining a plurality of fastener openings centered on an origin. A center of each of the plurality of fastener openings is disposed at a first radial distance from the origin. The origin defines an axis extending substantially orthogonally from a plane defined by two lines extending from the origin and at least two centers of the centers of the plurality of fastener openings. A first guard is secured to the base plate and includes a first guard retaining surface including a first curved surface defined by a second radial distance from the axis that is greater than the first radial distance and a first guard guiding surface having a first end adjacent the first guard retaining surface and a second end distal from the first end. The first end is disposed at the second radial distance from the axis. The second end is disposed at a third radial distance from the axis. The third radial distance is greater than the second radial distance.

Abstract: The present invention relates to compounds of formula I that function as inhibitors of BCL6 (B-cell lymphoma 6) activity: wherein X1, X2, R1, R2, R30, R31 and Ring A are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which BCL6 activity is implicated.