Patents by Inventor Alexander E. Arnold

Alexander E. Arnold has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GABA(A) RECEPTOR MODULATORS AND METHODS TO CONTROL AIRWAY HYPERRESPONSIVENESS AND INFLAMMATION IN ASTHMA
    Publication number: 20230103216
    Abstract: Pyrrolobenzodiazepines target alpha-4 and alpha-5 GABAA receptors for use in the treatment of airway hyperresponsiveness and inflammation in asthma. Compounds selectively partition to the peripheral compartment and have reduced CNS effects.
    Type: Application
    Filed: August 11, 2022
    Publication date: March 30, 2023
    Inventors: Alexander E. Arnold, Douglas C. Stafford, James M. Cook, Charles W. Emala, Gloria Forkuo, Rajwana Jahan, Revathi Kodali, Guanguan Li, Michael Rajesh Stephen
  • Substituted benzo[f]imidazo[1,5-a][1,4]diazepines as GABA(a) receptor modulators
    Patent number: 11447495
    Abstract: Substituted benzo[f]imidazo[1,5-?][1,4]diazepines of formula (I?) target alpha-4 and alpha-5 GABAA receptors for use in the treatment of airway hyperresponsiveness and inflammation in asthma. Compounds selectively partition to the peripheral compartment and have reduced CNS effects.
    Type: Grant
    Filed: August 16, 2017
    Date of Patent: September 20, 2022
    Assignees: UWM Research Foundation, Inc., The Trustees of Columbia University in the City of New York
    Inventors: Alexander E. Arnold, Douglas C. Stafford, James M. Cook, Charles W. Emala, Gloria Forkuo, Rajwana Jahan, Revathi Kodali, Guanguan Li, Michael Rajesh Stephen
  • GABA(A) RECEPTOR MODULATORS AND METHODS TO CONTROL AIRWAY HYPERRESPONSIVENESS AND INFLAMMATION IN ASTHMA
    Publication number: 20210284649
    Abstract: Pyrrolobenzodiazepines target alpha-4 and alpha-5 GABAA receptors for use in the treatment of airway hyperresponsiveness and inflammation in asthma. Compounds selectively partition to the peripheral compartment and have reduced CNS effects.
    Type: Application
    Filed: August 16, 2017
    Publication date: September 16, 2021
    Inventors: Alexander E. Arnold, Douglas C. Stafford, James M. Cook, Charles W. Emala, Gloria Forkuo, Rajwana Jahan, Revathi Kodali, Guanguan Li, Michael Rajesh Stephen
  • VITAMIN D RECEPTOR-COREGULATOR INHIBITORS
    Publication number: 20180362500
    Abstract: Described herein are compounds, pharmaceutical compositions and methods for inhibiting the expression of a vitamin D receptor target gene, inhibiting interactions between the vitamin D receptor and at least one vitamin D receptor coactivator, for treating cancer in a subject, and for inhibiting angiogenesis in a subject.
    Type: Application
    Filed: August 29, 2018
    Publication date: December 20, 2018
    Inventors: Alexander E. Arnold, Preetpal Singh Sidhu, Premchendar Nandhikonda, Rakesh K. Singh
  • Vitamin D receptor-coregulator inhibitors
    Patent number: 10093653
    Abstract: Described herein are compounds, pharmaceutical compositions and methods for inhibiting the expression of a vitamin D receptor target gene, inhibiting interactions between the vitamin D receptor and at least one vitamin D receptor coactivator, for treating cancer in a subject, and for inhibiting angiogenesis in a subject.
    Type: Grant
    Filed: August 16, 2016
    Date of Patent: October 9, 2018
    Assignees: UWM Research Foundation, Inc., Women and Infants Hospital of Rhode Island
    Inventors: Alexander E. Arnold, Preetpal Singh Sidhu, Premchendar Nandhikonda, Rakesh K. Singh
  • GABAA agonists and methods of using to control airway hyperresponsiveness and inflammation in asthma
    Patent number: 9879020
    Abstract: Novel methods of treating inflammation and airway constriction using GABAergic compounds with reduced benzo-diazepine-like CNS activity are provided. Novel compounds which selectively target alpha-4 and alpha-5 GABAA receptors and methods of using those compounds to treat bronchoconstriction and inflammation are provided herein.
    Type: Grant
    Filed: September 20, 2013
    Date of Patent: January 30, 2018
    Assignees: UWM Research Foundation, Inc., The Trustees of Columbia University in the City of New York
    Inventors: Douglas C. Stafford, James M. Cook, Alexander E. Arnold, Charles W. Emala, George Gallos, Michael Rajesh Stephen
  • VITAMIN D RECEPTOR-COREGULATOR INHIBITORS
    Publication number: 20170174655
    Abstract: Described herein are compounds, pharmaceutical compositions and methods for inhibiting the expression of a vitamin D receptor target gene, inhibiting interactions between the vitamin D receptor and at least one vitamin D receptor coactivator, for treating cancer in a subject, and for inhibiting angiogenesis in a subject.
    Type: Application
    Filed: August 16, 2016
    Publication date: June 22, 2017
    Inventors: Alexander E. Arnold, Preetpal Singh Sidhu, Premchendar Nandhikonda, Rakesh K. Singh
  • Vitamin D receptor-coregulator inhibitors
    Patent number: 9416104
    Abstract: Described herein are compounds, pharmaceutical compositions and methods for inhibiting the expression of a vitamin D receptor target gene, inhibiting interactions between the vitamin D receptor and at least one vitamin D receptor coactivator, for treating cancer in a subject, and for inhibiting angiogenesis in a subject.
    Type: Grant
    Filed: August 26, 2012
    Date of Patent: August 16, 2016
    Assignees: UWM Research Foundation, Inc., Women and Infants' Hospital of Rhode Island
    Inventors: Alexander E. Arnold, Preetpal Singh Sidhu, Premchendar Nandhikonda, Rakesh K. Singh
  • NOVEL GABAA AGONISTS AND METHODS OF USING TO CONTROL AIRWAY HYPERRESPONSIVENESS AND INFLAMMATION IN ASTHMA
    Publication number: 20150232473
    Abstract: Novel methods of treating inflammation and airway constriction using GABAergic compounds with reduced benzo-diazepine-like CNS activity are provided. Novel compounds which selectively target alpha-4 and alpha-5 GABAA receptors and methods of using those compounds to treat bronchoconstriction and inflammation are provided herein.
    Type: Application
    Filed: September 20, 2013
    Publication date: August 20, 2015
    Inventors: Douglas C. Stafford, James M. Cook, Alexander E. Arnold, Charles W. Emala, George Gallos, Michael Rajesh Stephen
  • VITAMIN D RECEPTOR-COREGULATOR INHIBITORS
    Publication number: 20140194472
    Abstract: Described herein are compounds, pharmaceutical compositions and methods for inhibiting the expression of a vitamin D receptor target gene, inhibiting interactions between the vitamin D receptor and at least one vitamin D receptor coactivator, for treating cancer in a subject, and for inhibiting angiogenesis in a subject.
    Type: Application
    Filed: August 26, 2012
    Publication date: July 10, 2014
    Applicants: WOMEN AND INFANTS' HOSPITAL OF RHODE ISLAND, UWM RESEARCH FOUNDATION, INC.
    Inventors: Alexander E. Arnold, Preetpal Singh Sidhu, Premchendar Nandhikonda, Rakesh K. Singh