Patents by Inventor Alexander E. MacKenzie

Alexander E. MacKenzie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mammalian IAP gene family, primers, probes and detection methods
    Patent number: 7776552
    Abstract: Disclosed is substantially pure DNA encoding mammalian IAP polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to inhibit apoptosis. Also disclosed are conserved regions characteristic of the IAP family and primer and probes for the identification and isolation of additional IAP genes. In addition, methods for treating diseases and disorders involving apoptosis are provided.
    Type: Grant
    Filed: August 3, 2006
    Date of Patent: August 17, 2010
    Assignee: University of Ottawa
    Inventors: Robert G. Korneluk, Alexander E. MacKenzie, Stephen Baird, Peter Liston
  • DETECTION AND MODULATION OF IAPs AND NAIP FOR THE DIAGNOSIS AND TREATMENT OF PROLIFERATIVE DISEASE
    Publication number: 20090142334
    Abstract: Disclosed are diagnostic and prognostic kits for the detection and treatment of proliferative diseases such as ovarian cancer, breast cancer, and lymphoma. Also disclosed are cancer therapeutics utilizing IAP antisense nucleic acids, IAP fragments, and antibodies which specifically bind IAP polypeptides.
    Type: Application
    Filed: April 28, 2008
    Publication date: June 4, 2009
    Applicant: AEGERA THERPEUTICS, INC.
    Inventors: Robert G. Korneluk, Alexander E. Mackenzie, Peter Liston, Stephen Baird, Benjamin K. Tsang, Christine Pratt
  • Detection and modulation of IAPs and NAIP for the diagnosis and treatment of proliferative disease
    Publication number: 20070219360
    Abstract: Disclosed are diagnostic and prognostic kits for the detection and treatment of proliferative diseases such as ovarian cancer, breast cancer, and lymphoma. Also disclosed are cancer therapeutics utilizing IAP antisense nucleic acids, IAP fragments, and antibodies which specifically bind IAP polypeptides.
    Type: Application
    Filed: August 25, 2006
    Publication date: September 20, 2007
    Inventors: Robert G. Korneluk, Alexander E. MacKenzie, Peter Liston, Stephen Baird, Benjamin K. Tsang, Christine Pratt
  • Use of neuronal apoptosis inhibitor protein (NAIP)
    Patent number: 7235372
    Abstract: The invention provides a novel NAIP nucleic and sequences. Also provided are anti-NAIP antibodies and methods for modulating apoptosis and detecting compounds which modulate apoptosis.
    Type: Grant
    Filed: January 10, 2006
    Date of Patent: June 26, 2007
    Assignee: University of Ottawa
    Inventors: Robert G. Korneluk, Alexander E. MacKenzie, Natalie Roy, George Robertson, Katsu Tamai
  • Detection and modulation of IAPs and NAIP for the diagnosis and treatment of proliferative disease
    Patent number: 7087584
    Abstract: Disclosed are diagnostic and prognostic kits for the detection and treatment of proliferative diseases such as ovarian cancer, breast cancer, and lymphoma. Also disclosed are cancer therapeutics utilizing IAP antisense nucleic acids IAP fragments, and antibodies which specifically bind IAP polypeptides.
    Type: Grant
    Filed: October 9, 2001
    Date of Patent: August 8, 2006
    Assignee: Aegera Therapeutics Inc.
    Inventors: Robert G. Korneluk, Alexander E. Mackenzie, Peter Liston, Stephen Baird, Benjamin K. Tsang, Christine Pratt
  • Mammalian IAP gene family, primers, probes and detection methods
    Patent number: 7067281
    Abstract: Disclosed is substantially pure DNA encoding mammalian IAP polypeptides; substantially pure polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to inhibit apoptosis. Also disclosed are conserved regions characteristic of the IAP family and primers and probes for the identification and isolation of additional IAP genes. In addition, methods for treating diseases and disorders involving apoptosis are provided.
    Type: Grant
    Filed: June 20, 2003
    Date of Patent: June 27, 2006
    Assignee: Aegera Therapeutics, Inc.
    Inventors: Robert G. Korneluk, Alexander E. MacKenzie, Stephen Baird, Peter Liston
  • Use of neuronal apoptosis inhibitor protein (NAIP)
    Patent number: 6994957
    Abstract: The invention provides NAIP nucleic acid and sequences. Also provided are anti-NAIP antibodies and methods for modulating apoptosis and detecting compounds which modulate apoptosis.
    Type: Grant
    Filed: January 17, 1997
    Date of Patent: February 7, 2006
    Assignee: University of Ottawa
    Inventors: Robert G. Korneluk, Alexander E. MacKenzie, Natalie Roy, George Robertson
  • Mammalian IAP gene family, primers, probes, and detection methods
    Patent number: 6977158
    Abstract: Disclosed is substantially pure DNA encoding mammalian IAP polypeptides; substantially pure polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to inhibit apoptosis. Also disclosed are conserved regions characteristic of the IAP family and primers and probes for the identification and isolation of additional IAP genes. In addition, methods for treating diseases and disorders involving apoptosis are provided.
    Type: Grant
    Filed: September 1, 2000
    Date of Patent: December 20, 2005
    Assignee: University of Ottawa
    Inventors: Robert G. Korneluk, Alexander E. MacKenzie, Stephen Baird
  • XAF genes and polypeptides: methods and reagents for modulating apoptosis
    Patent number: 6946544
    Abstract: The invention provides novel XAF nucleic acid sequences. Also provided are XAF polypeptides, anti-XAF antibodies, and methods for modulating apoptosis and detecting compounds which modulate apoptosis.
    Type: Grant
    Filed: November 5, 2002
    Date of Patent: September 20, 2005
    Assignee: Aegera Therapeutics Inc.
    Inventors: Robert G. Korneluk, Katsuyuki Tamai, Peter Liston, Alexander E. MacKenzie
  • Mammalian IAP gene family, primers, probes and detection methods
    Publication number: 20040157232
    Abstract: Disclosed is substantially pure DNA encoding mammalian IAP polypeptides; substantially pure polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to inhibit apoptosis. Also disclosed are conserved regions characteristic of the IAP family and primers and probes for the identification and isolation of additional IAP genes. In addition, methods for treating diseases and disorders involving apoptosis are provided.
    Type: Application
    Filed: June 20, 2003
    Publication date: August 12, 2004
    Inventors: Robert G. Komeluk, Alexander E. MacKenzie, Stephen Baird, Peter Liston
  • Methods for enhancing survival of a neuron
    Patent number: 6709866
    Abstract: NAIP and IAP polypeptides prevent neuronal cell death caused by ischemia, neurodegenerative conditions, and axotomy. The invention provides methods for neuroprotection by the prevention of cell death and kits and methods for the identification of neuroprotective therapeutic compounds.
    Type: Grant
    Filed: December 11, 2000
    Date of Patent: March 23, 2004
    Assignee: Aegera Therapeutics, Inc.
    Inventors: George S. Robertson, Robert G. Korneluk, Alexander E. MacKenzie, Daigen Xu, Stephen J. Crocker
  • Mammalian IAP gene family, primers, probes and detection methods
    Patent number: 6689562
    Abstract: Disclosed is substantially pure DNA encoding mammalian IAP polypeptides; substantially pure polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to inhibit apoptosis. Also disclosed are conserved regions characteristic of the IAP family and primers and probes for the identification and isolation of additional IAP genes. In addition, methods for treating diseases and disorders involving apoptosis are provided.
    Type: Grant
    Filed: December 1, 1998
    Date of Patent: February 10, 2004
    Assignee: AEGERA Therapeutics Inc.
    Inventors: Robert G. Korneluk, Alexander E. MacKenzie, Stephen Baird, Peter Liston
  • Mammalian apoptosis inhibitor protein gene family, primers, probes and detection methods
    Patent number: 6656704
    Abstract: Disclosed is substantially pure DNA encoding mammalian IAP polypeptides; substantially pure polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to inhibit apoptosis. Also disclosed are conserved regions characteristic of the IAP family and primers and probes for the identification and isolation of additional IAP genes. In addition, methods for treating diseases and disorders involving apoptosis are provided.
    Type: Grant
    Filed: September 14, 1998
    Date of Patent: December 2, 2003
    Assignee: Aegera Therapeutics Inc.
    Inventors: Robert G. Korneluk, Alexander E. MacKenzie, Stephen Baird, Peter Liston
  • XAF genes and polypeptides: methods and reagents for modulating apoptosis
    Publication number: 20030215824
    Abstract: The invention provides novel XAF nucleic acid sequences. Also provided are XAF polypeptides, anti-XAF antibodies, and methods for modulating apoptosis and detecting compounds which modulate apoptosis.
    Type: Application
    Filed: November 5, 2002
    Publication date: November 20, 2003
    Applicant: Aegera Therapeutics Inc.
    Inventors: Robert G. Korneluk, Katsuyuki Tamai, Peter Liston, Alexander E. MacKenzie
  • Mammalian IAP gene family, primers, probes and detection methods
    Patent number: 6541457
    Abstract: Disclosed is substantially pure DNA encoding mammalian IAP polypeptides; substantially pure polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to inhibit apoptosis. Also disclosed are conserved regions characteristic of the IAP-family and primers and probes for the identification and isolation of additional IAP genes. In addition, methods for treating diseases and disorders involving apoptosis are provided.
    Type: Grant
    Filed: December 1, 1998
    Date of Patent: April 1, 2003
    Assignee: Aegera Therapeutics Inc.
    Inventors: Robert G. Korneluk, Alexander E. MacKenzie, Stephen Baird, Peter Liston
  • Method of identifying a compound that modulates XAF-mediated apoptosis
    Patent number: 6495339
    Abstract: The invention provides novel XAF nucleic acid sequences. Also provided are XAF polypeptides, anti-XAF antibodies, and methods for modulating apoptosis and detecting compounds which modulate apoptosis.
    Type: Grant
    Filed: July 14, 2000
    Date of Patent: December 17, 2002
    Assignee: Aegera Therapeutics Inc.
    Inventors: Robert G. Korneluk, Katsuyuki Tamai, Peter Liston, Alexander E. MacKenzie
  • MAMMALIAN IAP GENE FAMILY, PRIMERS, PROBES AND DETECTION METHODS
    Publication number: 20020187946
    Abstract: Disclosed is substantially pure DNA encoding mammalian IAP polypeptides; substantially pure polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to inhibit apoptosis. Also disclosed are conserved regions characteristic of the IAP family and primers and probes for the identification and isolation of additional IAP genes. In addition, methods for treating diseases and disorders involving apoptosis are provided.
    Type: Application
    Filed: December 1, 1998
    Publication date: December 12, 2002
    Inventors: ROBERT G. KORNELUK, ALEXANDER E. MACKENZIE, STEPHEN BAIRD, PETER LISTON
  • USE OF NEURONAL APOPTOSIS INHIBITOR PROTEIN (NAIP)
    Publication number: 20020137028
    Abstract: The invention provides NAIP nucleic acid and sequences. Also provided are antiNAIP antibodies and methods for modulating apoptosis and detecting compounds which modulate apoptosis.
    Type: Application
    Filed: September 12, 1997
    Publication date: September 26, 2002
    Inventors: ROBERT G KORNELUK, ALEXANDER E. MACKENZIE, NATALIE ROY, GEORGE ROBERTSON, KATSU TAMAI
  • Detection and modulation of IAPs and NAIP for the diagnosis and treatment of proliferative disease
    Publication number: 20020120121
    Abstract: Disclosed are diagnostic and prognostic kits for the detection and treatment of proliferative diseases such as ovarian cancer, breast cancer, and lymphoma. Also disclosed are cancer therapeutics utilizing IAP antisense nucleic acids IAP fragments, and antibodies which specifically bind IAP polypeptides.
    Type: Application
    Filed: October 9, 2001
    Publication date: August 29, 2002
    Inventors: Robert G. Korneluk, Alexander E. Mackenzie, Peter Liston, Stephen Baird, Benjamin K. Tsang, Christine Pratt
  • Modulation of IAPs for the diagnosis and antisense treatment of proliferative disease
    Patent number: 6300492
    Abstract: Disclosed are diagnostic and prognostic kits for the detection and treatment of proliferative diseases such as ovarian cancer, breast cancer, and lymphoma. Also disclosed are cancer therapeutics utilizing IAP antisense nucleic acids IAP fragments, and antibodies which specifically bind IAP polypeptides.
    Type: Grant
    Filed: July 14, 2000
    Date of Patent: October 9, 2001
    Assignee: Aegera Therapeutics Inc.
    Inventors: Robert G. Korneluk, Alexander E. Mackenzie, Peter Liston, Stephen Baird, Benjamin K. Tsang, Christine Pratt