Abstract: Techniques for classifying cancers using fragmentomic features are described. An example method includes identifying data indicative of circulating tumor DNA (ctDNA) from a sample derived from a subject. The example method further includes identifying fragmentomic features based on the data. Input data, including the fragmentomic features, is input into a model configured to generate at least one probability that a tumor is within at least one category. The example method further includes generating a report based on the at least one probability that the tumor is within the at least one category.

Abstract: Techniques for calculating a tumor fraction of a subject are described. In an example method, sequence read data of a sample obtained from a subject is identified. The sequence read data indicates sequences of DNA fragments. The example method further includes determining endpoint positions of the DNA fragments with respect to a reference genome; determining input features; and calculating a tumor fraction of the subject. The endpoint positions of the DNA fragments can be determined based on the sequence read data. The input features are based on the endpoint positions of the DNA fragments with respect to the reference genome and can be determined by using a classifier. The tumor fraction can be calculated based on the input features.

Abstract: Techniques for identifying a non-cancer condition of a subject are described. In an example method, sequence read data of a sample obtained from the subject is identified. The sequence read data is indicative of endpoint positions of nucleic acid molecules in the sample. The example method further comprises determining endpoint positions of the nucleic acid molecules, generating input features based on the endpoint positions of the nucleic acid molecules, and classifying, using a classifier, the non-cancer condition of the subject based on the input features.

Abstract: Techniques for identifying a condition, such as a tumor classification, of a subject are described. In an example method, sequence read data of a sample obtained from the subject is identified. The sequence read data is indicative of endpoint positions of nucleic acid molecules in the sample. The example method further comprises determining endpoint positions of the nucleic acid molecules, generating input features based on the endpoint positions of the nucleic acid molecules, and classifying, using a classifier, the condition of the subject based on the input features.

Abstract: Techniques for identifying a cancer type of a subject are described. An example method includes identifying sequence read data indicating sequences of DNA fragments of a sample obtained from a subject. Based on the sequence read data, endpoint positions of the DNA fragments with respect to a reference genome are identified. Further, input features are determined based on the endpoint positions of the DNA fragments with respect to the reference genome. The example method further includes predicting, using a classifier and based on the input features, a primary type of cancer of the subject.

Abstract: Techniques for identifying a copy number state of a subject are described. An example method includes identifying sequence read data indicating sequences of DNA fragments of a sample obtained from the subject. Based on the sequence read data, fragmentomic features of the DNA fragments with respect to a reference genome are determined. Further, the example method includes determining input features based on the fragmentomic features and determining, using a classifier and based on the input features, the copy number state of the subject.

Abstract: Techniques for identifying a condition subtype of a subject are described. An example method includes identifying sequence read data indicating sequences of DNA fragments of a sample obtained from a subject with cancer; and determining, based on the sequence read data, endpoint positions of the DNA fragments with respect to a reference genome. Input features are determined based on the endpoint positions of the DNA fragments with respect to the reference genome. Using a classifier, and based on the input features, a subtype of the cancer of the subject is determined.

Abstract: Disclosed herein are methods and systems for determining an origin of viral sequence reads detected in a sample (e.g., a liquid biopsy sample) from an individual. The sample may contain cfDNA fragments of varying fragment lengths. Embodiments of the present disclosure can receive sequence read data associated with the sample, which may be a liquid biopsy sample. The sequence read data can be used to determine if one or more viral sequence reads are detected in the sample. If the viral sequence reads are detected, the system can determine one or more fragmentomic features based on the sequence read data. The system can then generate an output indicative of the origin of the viral sequence reads by inputting the fragmentomic features into a statistical model including, for example, a trained machine-learning model. Based on the output, the system can then determine whether the viral sequence reads originate from a tumor.

Abstract: A drill pipe, particularly for a drill string, having an outer and an inner pipe (3), a female connector (4) with an internal thread at one end of the drill pipe (1), and a male connector (5) with an external thread at the end opposite from the female connector (4), wherein the inner pipe (3) is arranged substantially concentrically in the outer pipe (2) and the drill pipe (1) has a center region (8) with an internal diameter. The outer pipe (2) has an inwardly thickened wall portion at an end region (7) on the male connector side, having a smaller internal diameter than the internal diameter of the center region (8), and the internal diameter of the outer pipe (2) remains substantially the same at an end region (6) on the female connector side in relation to the internal diameter of the center region (8).

Abstract: A drill pipe (1), particularly for a drill string, has at least one electrical conductor (4, 7, 8, 9) and an inner pipe (2) which is arranged inside the drill pipe (1). The drill pipe (1) and the inner pipe (2) are spaced at a distance to one another in sections, wherein the drill pipe (1) and inner pipe (2) bound a hollow space (3). At least one electrical conductor (4, 7, 8, 9) is arranged on one outer side of the inner pipe.

Abstract: A device for connecting at least one electrical data and/or supply line to electrical sockets of a wired drill pipe is disclosed. One inventive aspect of the device comprises: a collet blocking plug axially insertable into and removable from a receiver end of the drill pipe and at least one collet. The collet is configured to be interlocked with the drill pipe in a locking position and be released from the drill pipe in a release position. The collet is axially displaceable from the collet blocking plug between the locking position and the release position. The collet blocking plug is axially insertable into and removable from a receiver end of the drill pipe.

Abstract: A drill pipe, particularly for a drill string, having an outer and an inner pipe (3), a female connector (4) with an internal thread at one end of the drill pipe (1), and a male connector (5) with an external thread at the end opposite from the female connector (4), wherein the inner pipe (3) is arranged substantially concentrically in the outer pipe (2) and the drill pipe (1) has a center region (8) with an internal diameter. The outer pipe (2) has an inwardly thickened wall portion at an end region (7) on the male connector side, having a smaller internal diameter than the internal diameter of the center region (8), and the internal diameter of the outer pipe (2) remains substantially the same at an end region (6) on the female connector side in relation to the internal diameter of the center region (8).

Abstract: A drill pipe (1), particularly for a drill string, has at least one electrical conductor (4, 7, 8, 9) and an inner pipe (2) which is arranged inside the drill pipe (1). The drill pipe (1) and the inner pipe (2) are spaced at a distance to one another in sections, wherein the drill pipe (1) and inner pipe (2) bound a hollow space (3). At least one electrical conductor (4, 7, 8, 9) is arranged on one outer side of the inner pipe.

Abstract: A device for connecting at least one electrical data and/or supply line to electrical sockets of a wired drill pipe is disclosed. One inventive aspect of the device comprises: a collet blocking plug axially insertable into and removable from a receiver end of the drill pipe and at least one collet. The collet is configured to be interlocked with the drill pipe in a locking position and be released from the drill pipe in a release position. The collet is axially displaceable from the collet blocking plug between the locking position and the release position. The collet blocking plug is axially insertable into and removable from a receiver end of the drill pipe.