Patents by Inventor Alexander Gall

Alexander Gall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SULFORHODAMINE PHOSPHORAMIDITE DYES
    Publication number: 20240067824
    Abstract: Automated oligonucleotide synthesis-compatible sulforhodamine dye phosphoramidite compounds and labeled polynucleotides incorporating these dyes are provided.
    Type: Application
    Filed: May 7, 2019
    Publication date: February 29, 2024
    Inventors: Kevin P. LUND, Dmitri SERGUEEV, Maher N. QABAR, Alexander GALL
  • Nucleic acid decontamination methods
    Patent number: 11819584
    Abstract: Methods and cleaning compositions for reduction of nucleic acid contamination on surfaces, in air, and in solutions using modified pectin are provided.
    Type: Grant
    Filed: August 16, 2019
    Date of Patent: November 21, 2023
    Assignee: Cepheid
    Inventors: Alex I. Kutyavin, Kevin P. Lund, Oliver Z. Nanassy, Alexander A. Gall, William Brabant
  • Fluorescent dyes
    Patent number: 11807643
    Abstract: Automated oligonucleotide synthesis-compatible fluorescent dye phosphoramidite compounds, solid supports, and labeled polynucleotides incorporating the compounds are provided. The compounds allow universal incorporation of the fluorescent label into any position of the polynucleotide.
    Type: Grant
    Filed: July 13, 2021
    Date of Patent: November 7, 2023
    Assignee: Cepheid
    Inventors: Kevin P. Lund, Dmitri Sergueev, Alexander Gall
  • Integrated purification and measurement of DNA methylation and co-measurement of mutations and/or MRNA expression levels in an automated reaction cartridge
    Patent number: 11603555
    Abstract: In various embodiments methods of determining methylation of DNA are provided.
    Type: Grant
    Filed: June 14, 2016
    Date of Patent: March 14, 2023
    Assignee: CEPHEID
    Inventors: Edwin W. Lai, Andrew Kohlway, Reuel Vanatta, Russell Higuchi, Alexander Gall, Kriszten Kocmond
  • THERMOSTABLE POLYMERASE INHIBITOR COMPOSITIONS AND METHODS
    Publication number: 20220389427
    Abstract: The present disclosure relates to aptamers for temperature-dependent reversible inhibition of thermostable polymerase activity in order to improve sensitivity and specificity of various reactions and assays involving hot start polynucleotide synthesis. Methods for use of the aptamers and related compositions and kits are also provided.
    Type: Application
    Filed: March 4, 2022
    Publication date: December 8, 2022
    Applicant: Cepheid
    Inventors: Sergey G. Lokhov, Alexander A. Gall, Vera Baraznenok, Ekaterina V. Viazovkina, Irina Shishkina, David H. Persing
  • INTEGRATED PURIFICATION AND MEASUREMENT OF DNA METHYLATION AND CO-MEASUREMENT OF MUTATIONS AND/OR MRNA EXPRESSION LEVELS IN AN AUTOMATED REACTION CARTRIDGE
    Publication number: 20220226809
    Abstract: Methods of determining methylation of DNA are provided.
    Type: Application
    Filed: January 27, 2022
    Publication date: July 21, 2022
    Applicant: Cepheid
    Inventors: Edwin Wei-Lung Lai, Andrew Kohlway, Reuel Van Atta, Russell Higuchi, Alexander A. Gall, Kriszten Kocmond
  • Thermostable polymerase inhibitor compositions and methods
    Patent number: 11299739
    Abstract: The present disclosure relates to aptamers for temperature-dependent reversible inhibition of thermostable polymerase activity in order to improve sensitivity and specificity of various reactions and assays involving hot start polynucleotide synthesis. Methods for use of the aptamers and related compositions and kits are also provided.
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: April 12, 2022
    Assignee: CEPHEID
    Inventors: Sergey G. Lokhov, Alexander A. Gall, Vera Baraznenok, Ekaterina V. Viazovkina, Irina Shishkina, David H. Persing
  • Integrated purification and measurement of DNA methylation and co-measurement of mutations and/or mRNA expression levels in an automated reaction cartridge
    Patent number: 11260387
    Abstract: Methods of determining methylation of DNA are provided.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: March 1, 2022
    Assignee: CEPHEID
    Inventors: Edwin Wei-Lung Lai, Andrew Kohlway, Reuel Van Atta, Russell Higuchi, Alexander A. Gall, Kriszten Kocmond
  • NONIONIC POLYETHER SURFACTANTS
    Publication number: 20220017480
    Abstract: Non-ionic polyether surfactants with improved resistance to hydrolysis are provided.
    Type: Application
    Filed: July 13, 2021
    Publication date: January 20, 2022
    Applicant: Cepheid
    Inventors: Alexander A. Gall, Ivan Baraznenok
  • FLUORESCENT DYES
    Publication number: 20220017531
    Abstract: Automated oligonucleotide synthesis-compatible fluorescent dye phosphoramidite compounds, solid supports, and labeled polynucleotides incorporating the compounds are provided. The compounds allow universal incorporation of the fluorescent label into any position of the polynucleotide.
    Type: Application
    Filed: July 13, 2021
    Publication date: January 20, 2022
    Applicant: Cepheid
    Inventors: Kevin P. Lund, Dmitri Sergueev, Alexander Gall
  • METHODS AND COMPOSITIONS FOR NUCLEIC ACID ISOLATION
    Publication number: 20210324372
    Abstract: Methods and compositions for isolation of nucleic acids from biological samples are provided.
    Type: Application
    Filed: August 16, 2019
    Publication date: October 21, 2021
    Applicant: Cepheid
    Inventors: Vera BARAZNENOK, Alex I. KUTYAVIN, Oliver Z. NANASSY, Dmitri SERGUEEV, Alexander A. GALL
  • NUCLEIC ACID ISOLATION AND RELATED METHODS
    Publication number: 20210238583
    Abstract: Solid supports modified with pectins derivatives are provided. The solid supports are useful in nucleic acid isolation, separation, and detection methods.
    Type: Application
    Filed: August 16, 2019
    Publication date: August 5, 2021
    Applicant: Cepheid
    Inventors: Alex I. KUTYAVIN, Oliver Z. NANASSY, Dmitri SERGUEEV, Alexander A. GALL
  • NUCLEIC ACID DECONTAMINATION METHODS
    Publication number: 20210162085
    Abstract: Methods and cleaning compositions for reduction of nucleic acid contamination on surfaces, in air, and in solutions using modified pectin are provided.
    Type: Application
    Filed: August 16, 2019
    Publication date: June 3, 2021
    Applicant: Cepheid
    Inventors: Alex I. KUTYAVIN, Kevin P. LUND, Oliver Z. NANASSY, Alexander A. GALL, William BRABANT
  • THERMOSTABLE POLYMERASE INHIBITOR COMPOSITIONS AND METHODS
    Publication number: 20190316132
    Abstract: The present disclosure relates to aptamers for temperature-dependent reversible inhibition of thermostable polymerase activity in order to improve sensitivity and specificity of various reactions and assays involving hot start polynucleotide synthesis. Methods for use of the aptamers and related compositions and kits are also provided.
    Type: Application
    Filed: June 6, 2017
    Publication date: October 17, 2019
    Inventors: Sergey G. Lokhov, Alexander A. Gall, Vera Baraznenok, Ekaterina V. Viazovkina, Irina Shishkina, David H. Persing
  • INTEGRATED PURIFICATION AND MEASUREMENT OF DNA METHYLATION AND CO-MEASUREMENT OF MUTATIONS AND/OR MRNA EXPRESSION LEVELS IN AN AUTOMATED REACTION CARTRIDGE
    Publication number: 20180214864
    Abstract: Methods of determining methylation of DNA are provided.
    Type: Application
    Filed: December 12, 2017
    Publication date: August 2, 2018
    Inventors: EDWIN WEI-LUNG LAI, ANDREW KOHLWAY, REUEL VAN ATTA, RUSSELL HIGUCHI, ALEXANDER A. GALL, KRISZTEN KOCMOND
  • INTEGRATED PURIFICATION AND MEASUREMENT OF DNA METHYLATION AND CO-MEASUREMENT OF MUTATIONS AND/OR MRNA EXPRESSION LEVELS IN AN AUTOMATED REACTION CARTRIDGE
    Publication number: 20170137871
    Abstract: In various embodiments methods of determining methylation of DNA are provided.
    Type: Application
    Filed: June 14, 2016
    Publication date: May 18, 2017
    Inventors: EDWIN W. LAI, ANDREW KOHLWAY, REUEL VANATTA, RUSSELL HIGUCHI, ALEXANDER GALL, KRISZTEN KOCMOND
  • Modified thymine polynucleotide oligomers and methods
    Patent number: 9598455
    Abstract: Disclosed are modified thymine bases that provide enhanced base-pairing affinity for adenine or 2,6-diaminopurine bases in polynucleotide hybridization complexes. Also disclosed are polynucleotide oligomers, polynucleotide hybridization complexes that comprise such modified thymine bases. Also disclosed are various methods of use. For example, in some embodiments, modified polynucleotide oligomers disclosed herein can be used as primers and probes for nucleic acid amplification and/or detection.
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: March 21, 2017
    Assignee: Cepheid
    Inventors: Alexander A. Gall, Sergey G. Lokhov, Mikhail A. Podyminogin, Ekaterina V. Viazovkina, Kevin Patrick Lund
  • Modified cytosine polynucleotide oligomers and methods
    Patent number: 9598456
    Abstract: Disclosed are modified cytosine bases that provide enhanced base-pairing affinity for guanine bases in polynucleotide hybridization complexes. Also disclosed are polynucleotide oligomers, polynucleotide hybridization complexes that comprise such modified cytosine bases. Also disclosed are various methods of use. For example, in some embodiments, modified polynucleotide oligomers disclosed herein can be used as primers and probes for nucleic acid amplification and/or detection.
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: March 21, 2017
    Assignee: Cepheid
    Inventors: Alexander A. Gall, Sergey G. Lokhov, Mikhail A. Podyminogin, Ekaterina V. Viazovkina, Kevin Patrick Lund
  • MODIFIED CYTOSINE POLYNUCLEOTIDE OLIGOMERS AND METHODS
    Publication number: 20150275283
    Abstract: Disclosed are modified cytosine bases that provide enhanced base-pairing affinity for guanine bases in polynucleotide hybridization complexes. Also disclosed are polynucleotide oligomers, polynucleotide hybridization complexes that comprise such modified cytosine bases. Also disclosed are various methods of use. For example, in some embodiments, modified polynucleotide oligomers disclosed herein can be used as primers and probes for nucleic acid amplification and/or detection.
    Type: Application
    Filed: March 30, 2015
    Publication date: October 1, 2015
    Inventors: Alexander A. GALL, Sergey G. Lokhov, Mikhail A. Podyminogin, Ekaterina V. Viazovkina, Kevin Patrick Lund
  • MODIFIED THYMINE POLYNUCLEOTIDE OLIGOMERS AND METHODS
    Publication number: 20150275278
    Abstract: Disclosed are modified thymine bases that provide enhanced base-pairing affinity for adenine or 2,6-diaminopurine bases in polynucleotide hybridization complexes. Also disclosed are polynucleotide oligomers, polynucleotide hybridization complexes that comprise such modified thymine bases. Also disclosed are various methods of use. For example, in some embodiments, modified polynucleotide oligomers disclosed herein can be used as primers and probes for nucleic acid amplification and/or detection.
    Type: Application
    Filed: March 30, 2015
    Publication date: October 1, 2015
    Inventors: Alexander A. GALL, Sergey G. LOKHOV, Mikhail A. PODYMINOGIN, Ekaterina V. VIAZOVKINA, Kevin Patrick LUND