Patents by Inventor Alexander Glazer

Alexander Glazer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200354780
    Abstract: A method of forming a polymer matrix array includes applying an aqueous solution into wells of a well array. The aqueous solution includes polymer precursors. The method further includes applying an immiscible fluid over the well array to isolate the aqueous solution within the wells of the well array and polymerizing the polymer precursors isolated in the wells of the well array to form the polymer matrix array. An apparatus includes a sensor array, a well array corresponding to the sensor array, and an array of polymer matrices disposed in the well array.
    Type: Application
    Filed: July 24, 2020
    Publication date: November 12, 2020
    Inventors: David LIGHT, Wolfgang HINZ, Ronald CICERO, Christina INMAN, Paul KENNEY, Alexander MASTROIANNI, Roman ROZHKOV, Yufang WANG, Jeremy GRAY, Marc GLAZER, Dmitriy GREMYACHINSKIY
  • Publication number: 20200346212
    Abstract: A method of modifying a microfabricated chip made of a hydrophobic material is provided. The microfabricated chip has a top surface including a plurality of microwells each having a bottom and a side wall, and interstitial space between the microwells. First, the ed chip is surface treated to render the surface of the bottom and side wall of the microwells and the interstitial space hydrophilic. Then, the surface of the interstitial space is treated to render it hydrophobic. A microfabricated chip having hydrophilic microwells and hydrophobic interstitial space is also provided.
    Type: Application
    Filed: May 1, 2020
    Publication date: November 5, 2020
    Inventors: Alexander Hallock, Marc Glazer
  • Patent number: 10809225
    Abstract: A sensor component includes a sensor including a sensor surface and a reaction site in cooperation with the sensor and exposing the sensor surface. The reaction site including a reaction site surface. A surface agent is bound to the reaction site surface or the sensor surface. The surface agent includes a surface active functional group reactive with Bronsted base or Lewis acid functionality on the reaction site surface or the sensor surface and including distal functionality that does not have a donor electron pair.
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: October 20, 2020
    Assignee: Life Technologies Corporation
    Inventors: Ronald L. Cicero, Marc Glazer, Yufang Wang, Christina E. Inman, Jeremy Gray, Joseph Koscinski, James A. Ball, Phil Waggoner, Alexander Mastroianni
  • Patent number: 10738353
    Abstract: A method of forming a polymer matrix array includes applying an aqueous solution into wells of a well array. The aqueous solution includes polymer precursors. The method further includes applying an immiscible fluid over the well array to isolate the aqueous solution within the wells of the well array and polymerizing the polymer precursors isolated in the wells of the well array to form the polymer matrix array. An apparatus includes a sensor array, a well array corresponding to the sensor array, and an array of polymer matrices disposed in the well array.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: August 11, 2020
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: David Light, Wolfgang Hinz, Ronald Cicero, Christina Inman, Paul Kenney, Alexander Mastroianni, Roman Rozhkov, Yufang Wang, Jeremy Gray, Marc Glazer, Dmitriy Gremyachinskiy
  • Patent number: 10724086
    Abstract: A sensor apparatus includes a substrate, a semiconductor device disposed over the substrate, the semiconductor device having a surface electrode structure, and a saccharide coating formed over the surface electrode structure. The saccharide coating can be removed prior to use. The semiconductor device can further include a well and optionally a bead disposed in the well.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: July 28, 2020
    Assignee: Life Technologies Corporation
    Inventors: Phil Waggoner, James A. Ball, Wolfgang Hinz, Michael L. Minto, Scott Parker, David M. Cox, Alexander Mastroianni, Jeremy Gray, Marc Glazer, Kimberly Gorrell
  • Publication number: 20200216893
    Abstract: A sensor apparatus includes a substrate, a semiconductor device disposed over the substrate, the semiconductor device having a surface electrode structure, and a saccharide coating formed over the surface electrode structure. The saccharide coating can be removed prior to use. The semiconductor device can further include a well and optionally a bead disposed in the well.
    Type: Application
    Filed: March 20, 2020
    Publication date: July 9, 2020
    Inventors: Phil Waggoner, James A. Ball, Wolfgang Hinz, Michael L. Minto, Scott Parker, David M. Cox, Alexander Mastroianni, Jeremy Gray, Marc Glazer, Kimberly Gorrell
  • Patent number: 10619201
    Abstract: A sensor apparatus includes a substrate, a semiconductor device disposed over the substrate, the semiconductor device having a surface electrode structure, and a saccharide coating formed over the surface electrode structure. The saccharide coating can be removed prior to use. The semiconductor device can further include a well and optionally a bead disposed in the well.
    Type: Grant
    Filed: November 6, 2018
    Date of Patent: April 14, 2020
    Assignee: Life Technologies Corporation
    Inventors: Phil Waggoner, James A. Ball, Wolfgang Hinz, Michael L. Minto, Scott Parker, David M. Cox, Alexander Mastroianni, Jeremy Gray, Marc Glazer, Kimberly Gorrell
  • Publication number: 20190228007
    Abstract: An interactive vehicle information map system is disclosed in which, in various embodiments, geographical, geospatial, vehicle, and other types of data, geodata, objects, features, and/or metadata are efficiently presented to a user on an interactive map interface. In an embodiment, the user may search vehicle-related data via the interactive map by providing search criteria including, for example, information regarding a geographic area, a time period, a vehicle, a vehicle owner, and/or a license plate number, among other items. The map system may provide search results including a list of vehicles that match the search criteria, vehicle information, and/or points on the interactive map that indicate license-plate recognition read locations, among other information. In an embodiment, the user may view detailed information associated with particular vehicles including, for example, captured images, vehicle-owner data, event history, and the like. Further, the user may export data and/or create search alerts.
    Type: Application
    Filed: March 29, 2019
    Publication date: July 25, 2019
    Inventors: Mitchell Beard, Michael Glazer, Robin Lim, Sina Iman, Mark Basoa, Tristan Huber, Paul Ryan, Youssef Moussaoui, Bonnie McLindon, Nick White, Alexander Vasilyev, Mark Lundquist
  • Patent number: 7015000
    Abstract: Fluorescent labels having at least one donor and at least one acceptor fluorophore bonded to a polymeric backbone in energy transfer relationship, as well as methods for their use, are provided. Of particular interest are the subject labels wherein the polymeric backbone is a nucleic acid and the donor fluorophore is bonded to the 5? terminus of said nucleic acid. Such labels find use as primers in applications involving nucleic acid chain extension, such as sequencing, PCR and the like.
    Type: Grant
    Filed: November 4, 2002
    Date of Patent: March 21, 2006
    Assignee: The Regents of the University of California
    Inventors: Richard Mathies, Alexander Glazer, Jingyue Ju
  • Publication number: 20060024743
    Abstract: Fluorescent labels having at least one donor and at least one acceptor fluorophore bonded to a polymeric backbone in energy transfer relationship, as well as methods for their use, are provided. Of particular interest are the subject labels wherein the polymeric backbone is a nucleic acid and the donor fluorophore is bonded to the 5? terminus of said nucleic acid. Such labels find use as primers in applications involving nucleic acid chain extension, such as sequencing, PCR and the like.
    Type: Application
    Filed: September 29, 2005
    Publication date: February 2, 2006
    Applicant: The Regents of the University of California
    Inventors: Richard Mathies, Alexander Glazer, Jingyue Ju
  • Publication number: 20030143594
    Abstract: Fluorescent labels having at least one donor and at least one acceptor fluorophore bonded to a polymeric backbone in energy transfer relationship, as well as methods for their use, are provided. Of particular interest are the subject labels wherein the polymeric backbone is a nucleic acid and the donor fluorophore is bonded to the 5′ terminus of said nucleic acid. Such labels find use as primers in applications involving nucleic acid chain extension, such as sequencing, PCR and the like.
    Type: Application
    Filed: November 4, 2002
    Publication date: July 31, 2003
    Applicant: The Regents of the University of California
    Inventors: Richard Mathies, Alexander Glazer, Jingyue Ju
  • Patent number: 6544744
    Abstract: Fluorescent labels having at least one donor and at least one acceptor fluorophore bonded to a polymeric backbone in energy transfer relationship, as well as methods for their use, are provided. Of particular interest are the subject labels wherein the polymeric backbone is a nucleic acid and the donor fluorophore is bonded to the 5′ terminus of said nucleic acid. Such labels find use as primers in applications involving nucleic acid chain extension, such as sequencing, PCR and the like.
    Type: Grant
    Filed: January 20, 2000
    Date of Patent: April 8, 2003
    Assignee: The Regents of the University of California
    Inventors: Richard Mathies, Alexander Glazer, Jingyue Ju
  • Patent number: 6177247
    Abstract: Compositions are provided comprising sets of fluorescent labeled oligonucleotides carrying pairs of donor and acceptor dye molecules, designed for efficient excitation of the donors at a single wavelength and emission from the acceptor in each of the pairs at different wavelengths. The different molecules having different donor-acceptor pairs can be modified to have substantially the same mobility and enhanced emission intensities under separation conditions, by varying the distance between the donor and acceptor in a given pair. Particularly, the fluorescent compositions find use as labels in analyzing double stranded and single stranded nucleic acid fragments using capillary electrophoresis.
    Type: Grant
    Filed: November 30, 1998
    Date of Patent: January 23, 2001
    Assignee: The Regents of the University of California
    Inventors: Richard Mathies, Alexander Glazer, Jingyue Ju
  • Patent number: 6028190
    Abstract: Fluorescent labels having at least one donor and at least one acceptor fluorophore bonded to a polymeric backbone in energy transfer relationship, as well as methods for their use, are provided. Of particular interest are the subject labels wherein the polymeric backbone is a nucleic acid and the donor fluorophore is bonded to the 5' terminus of said nucleic acid. Such labels find use as primers in applications involving nucleic acid chain extension, such as sequencing, PCR and the like.
    Type: Grant
    Filed: May 8, 1996
    Date of Patent: February 22, 2000
    Assignee: The Regents of the University of California
    Inventors: Richard Mathies, Alexander Glazer, Jingyue Ju
  • Patent number: 5869255
    Abstract: Compositions are provided comprising sets of fluorescent labeled oligonucleotides carrying pairs of donor and acceptor dye molecules, designed for efficient excitation of the donors at a single wavelength and emission from the acceptor in each of the pairs at different wavelengths. The different molecules having different donor-acceptor pairs can be modified to have substantially the same mobility and enhanced emission intensities under separation conditions, by varying the distance between the donor and acceptor in a given pair. Particularly, the fluorescent compositions find use as labels in analyzing double stranded and single stranded nucleic acid fragments using capillary electrophoresis.
    Type: Grant
    Filed: January 30, 1997
    Date of Patent: February 9, 1999
    Assignee: The Regents of the University of California
    Inventors: Richard Mathies, Alexander Glazer, Jingyue Ju
  • Patent number: 5707804
    Abstract: Compositions are provided for making oligonucleotides carrying pairs of donor and acceptor dye molecules, designed for efficient excitation of the donor at a single wavelength and emission from the acceptor in each of the pairs at different wavelengths. The different molecules having different donor-acceptor pairs can be modified to have substantially the same mobility under separation conditions, by varying the distance between the donor and acceptor in a given pair, and to have enhanced emission intensities from the acceptor. Particularly, the fluorescent compositions find use as labels in sequencing nucleic acids.
    Type: Grant
    Filed: March 27, 1995
    Date of Patent: January 13, 1998
    Assignee: The Regents of the University of California
    Inventors: Richard Mathies, Alexander Glazer, Jingyue Ju
  • Patent number: 5688648
    Abstract: Compositions are provided comprising sets of fluorescent labels carrying pairs of donor and acceptor dye molecules, designed for efficient excitation of the donors at a single wavelength and emission from the acceptor in each of the pairs at different wavelengths. The different molecules having different donor-acceptor pairs can be modified to have substantially the same mobility under separation conditions, by varying the distance between the donor and acceptor in a given pair. Particularly, the fluorescent compositions find use as labels in sequencing nucleic acids.
    Type: Grant
    Filed: December 19, 1995
    Date of Patent: November 18, 1997
    Assignee: The Regents of the University of California
    Inventors: Richard A. Mathies, Alexander Glazer, Jingyue Ju
  • Patent number: 5654419
    Abstract: Compositions are provided comprising sets of fluorescent labels carrying pairs of donor and acceptor dye molecules, designed for efficient excitation of the donors at a single wavelength and emission from the acceptor in each of the pairs at different wavelengths. The different molecules having different donor-acceptor pairs can be modified to have substantially the same mobility under separation conditions, by varying the distance between the donor and acceptor in a given pair. Particularly, the fluorescent compositions find use as labels in sequencing nucleic acids.
    Type: Grant
    Filed: February 1, 1994
    Date of Patent: August 5, 1997
    Assignee: The Regents of the University of California
    Inventors: Richard A. Mathies, Alexander Glazer, Jingyue Ju