Abstract: Cellulose-based scaffolds having fibrous structures, which include a decellularized macroalgae tissue from which cellular materials and nucleic acids are removed; implants including such cellulose-based scaffolds; and a decellularization process for the preparation thereof. The macroalgae tissue may be a green macroalgae tissue, a red macroalgae tissue, or a brown macroalgae tissue. The green macroalgae tissue may be a Cladophora sp. tissue; and the red macroalgae tissue may be a Bangia sp. tissue.

Abstract: A device and method are disclosed for regulated storage capacitor charging to high voltage. The device comprises an AC source configured to output an AC voltage, a voltage multiplier that constitutes a charging unit and a control unit. The control unit is configured to constantly sense the voltage on the storage capacitor and upon detecting that a predefined maximum charging voltage has been reached to react in at least one of the following ways: stop charging the storage capacitor, and closing an output switch so as to discharge of the storage capacitor through some load. The capacitance of each capacitor in the charging unit is substantially smaller than that of the storage capacitor so as achieve accurate maximum charging voltage as well as limited charging current.

Abstract: Methods and devices obtain cellular-component, e.g., proteins, RNA, DNA, metabolites, and combinations of these, from a solid tissue in-vivo using electroporation, and subsequently profile such tissue either inside or outside the subject's body. A method for determining if a solid tissue of a subject includes a benign or malignant tumor, or if a space occupying lesion (SOL) within the solid tissue is malignant or benign, includes placing at least one electroporation-electrode within the solid tissue, or within the SOL or in proximity thereto; applying pulsed electric field (PEF) via the at least one electroporation-electrode to thereby induce permeabilization of cells of the solid tissue or the SOL, and consequently release of at least one cellular-component therefrom to an extracellular matrix between and surrounding the cells; extracting the at least one cellular-component from the extracellular matrix.

Abstract: The present invention provides novel devices, systems and methods for cultivating macroalgae in a waterbody, more particularly in the sea/offshore.

Abstract: A method for improving a cell biomass includes de-ashing the cell biomass by applying pulsed electric field (PEF)- or constant electric field (CEF)-treatment to the cell biomass in a solvent, optionally under pressure higher than the ambient pressure, to thereby extract an ash fraction from the cell biomass into the solvent.

Abstract: A device and method are disclosed for regulated storage capacitor charging to high voltage. The device comprises an AC source configured to output an AC voltage, a voltage multiplier that constitutes a charging unit and a control unit. The control unit is configured to constantly sense the voltage on the storage capacitor and upon detecting that a predefined maximum charging voltage has been reached to react in at least one of the following ways: stop charging the storage capacitor, and closing an output switch so as to discharge of the storage capacitor through some load. The capacitance of each capacitor in the charging unit is substantially smaller than that of the storage capacitor so as achieve accurate maximum charging voltage as well as limited charging current.

Abstract: A method is for the extraction of a phytochemical, e.g., peptide or protein, or a chemical element from a macroalgae, by applying pulsed electric field (PEF)- or continuous electric field (CEF)-treatment to the macroalgae in a solvent, under pressure higher than the ambient pressure. A device and system carry out this method.

Abstract: A system and method for controlling microbial growth on and in medical devices and implants, especially biofilm infections, involves using pulsed electric fields (PEF). To eradicate at least a portion of a biofilm on a medical implant, for example, 1500 volts can be applied through an electrode system, with pulse duration of 50 ?s and pulse delivery frequency of 2 Hz. In the clinical setting, systemic microbial therapy can be combined with PEF to achieve a synergistic effect leading to improved eradication of infections.

Abstract: Systems and methods for controlling a tissue of a subject using applied pulsed electric fields. The system includes an electrode assembly configured to engage a skin tissue of a subject to deliver a series of electric field pulses to the skin tissue and a user input configured to receive an operational instruction for the series of electric field pulses. The system also includes at least one processor configured to access the operational instruction received by the user input and, using the operational instruction, create an electric field profile to be generated by the electrode assembly about the skin tissue of the subject to control a fibroblast characteristic while preserving a vascular perfusion in at least a portion of the skin tissue. The processor is also caused to control the electrode assembly using the electric field profile to deliver the series of electric field pulses to control the fibroblast characteristic.

Abstract: Systems and methods for controlling a tissue of a subject using applied pulsed electric fields. The system for controlling a therapy provided to a tissue of a subject using applied pulsed electric fields. The system includes an electrode assembly configured to engage a skin tissue of a subject to deliver a series of electric field pulses to the skin tissue and a user input configured to receive an operational instruction for the series of electric field pulses. The operational instruction defines at least one of a pulse duration, a pulse frequency, a pulse number, and a pulse amplitude. The system also includes at least one processor configured to access the operational instruction received by the user input and, using the operational instruction, create an electric field profile to be generated by the electrode assembly about the skin tissue of the subject to control a fibroblast characteristic while preserving a vascular perfusion in at least a portion of the skin tissue.

Abstract: A method is for the extraction of a phytochemical, e.g., peptide or protein, or a chemical element from a macroalgae, by applying pulsed electric field (PEF)- or continuous electric field (CEF)-treatment to the macroalgae in a solvent, under pressure higher than the ambient pressure. A device and system carry out this method.

Abstract: A system and method are provided for stimulating hair growth of a user. The system includes a stimulating unit in communication with a control unit. The stimulating unit includes at least one electrode to be placed on a region of the user, a pulser configured to send electronic pulses to the electrode, and a power supply which supplies power to the pulser. Operation of the system includes the steps of placing the at least one electrode on a region of the user, relaying a plurality of pulses to the electrode, terminating the pulses when a predetermined number of pulses have been delivered, and removing the electrode from the region of the user.