Patents by Inventor Alexander Goryaynov
Alexander Goryaynov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11932906Abstract: Apparatus and techniques for electrokinetic loading of samples of interest into sub-micron-scale reaction chambers are described. Embodiments include an integrated device and related apparatus for analyzing samples in parallel. The integrated device may include at least one reaction chamber formed through a surface of the integrated device and configured to receive a sample of interest, such as a molecule of nucleic acid. The integrated device may further include electrodes patterned adjacent to the reaction chamber that produce one or more electric fields that assist loading the sample into the reaction chamber. The apparatus may further include a sample reservoir having a fluid seal with the surface of the integrated device and configured to hold a suspension containing the samples.Type: GrantFiled: June 17, 2021Date of Patent: March 19, 2024Assignee: Quantum-Si IncorporatedInventors: Guojun Chen, Jeremy Lackey, Alexander Goryaynov, Gerard Schmid, Ali Kabiri, Jonathan M. Rothberg, Todd Rearick, Jonathan C. Schultz, Farshid Ghasemi, Keith G. Fife
-
Publication number: 20230175062Abstract: Provided herein are compositions, devices, systems and methods for single molecule sensing. Further provided are devices for nucleic acid sequencing. The compositions, devices, systems and methods described herein provide improved retrieval of biomolecule-based information.Type: ApplicationFiled: December 7, 2022Publication date: June 8, 2023Inventors: Jeremy LACKEY, Andres FERNANDEZ, David DODD, Alexander GORYAYNOV
-
Publication number: 20210310066Abstract: Apparatus and techniques for electrokinetic loading of samples of interest into sub-micron-scale reaction chambers are described. Embodiments include an integrated device and related apparatus for analyzing samples in parallel. The integrated device may include at least one reaction chamber formed through a surface of the integrated device and configured to receive a sample of interest, such as a molecule of nucleic acid. The integrated device may further include electrodes patterned adjacent to the reaction chamber that produce one or more electric fields that assist loading the sample into the reaction chamber. The apparatus may further include a sample reservoir having a fluid seal with the surface of the integrated device and configured to hold a suspension containing the samples.Type: ApplicationFiled: June 17, 2021Publication date: October 7, 2021Applicant: Quantum-Si IncorporatedInventors: Guojun Chen, Jeremy Lackey, Alexander Goryaynov, Gerard Schmid, Ali Kabiri, Jonathan M. Rothberg, Todd Rearick, Jonathan C. Schultz, Farshid Ghasemi, Keith G. Fife
-
Patent number: 11072827Abstract: Apparatus and techniques for electrokinetic loading of samples of interest into sub-micron-scale reaction chambers are described. Embodiments include an integrated device and related apparatus for analyzing samples in parallel. The integrated device may include at least one reaction chamber formed through a surface of the integrated device and configured to receive a sample of interest, such as a molecule of nucleic acid. The integrated device may further include electrodes patterned adjacent to the reaction chamber that produce one or more electric fields that assist loading the sample into the reaction chamber. The apparatus may further include a sample reservoir having a fluid seal with the surface of the integrated device and configured to hold a suspension containing the samples.Type: GrantFiled: January 4, 2019Date of Patent: July 27, 2021Assignee: Quantum-Si IncorporatedInventors: Guojun Chen, Jeremy Lackey, Alexander Goryaynov, Gerard Schmid, Ali Kabiri, Jonathan M. Rothberg, Todd Rearick, Jonathan C. Schultz, Farshid Ghasemi, Keith G. Fife
-
Publication number: 20210218218Abstract: Systems and methods are described for producing an amplitude-modulated laser pulse train. The laser pulse train can be used to cause fluorescence in materials at which the pulse trains are directed. The parameters of the laser pulse train are selected to increase fluorescence relative to a constant-amplitude laser pulse train. The amplitude-modulated laser pulse trains produced using the teachings of this invention can be used to enable detection of specific molecules in applications such as gene or protein sequencing.Type: ApplicationFiled: January 13, 2021Publication date: July 15, 2021Applicant: Quantum-Si IncorporatedInventors: Michael Bellos, Alexander Goryaynov, Benjamin Cipriany, Xinghua Shi, Faisal R. Ahmad
-
Patent number: 10731209Abstract: Methods of loading a molecule of interest into a sample well are provided. In some aspects, methods of loading a molecule of interest into a sample well involve loading a molecule of interest into a sample well in the presence of a crowding agent and/or a condensing agent. In some aspects, methods of loading a sequencing template into a sample well are provided.Type: GrantFiled: December 19, 2017Date of Patent: August 4, 2020Assignee: Quantum-Si IncorporatedInventors: James A. Ball, Jeremy Lackey, Brian Reed, Alexander Goryaynov, Jonathan M. Rothberg, Thomas Christian
-
Publication number: 20200219590Abstract: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.Type: ApplicationFiled: November 15, 2019Publication date: July 9, 2020Applicant: Quantum-Si IncorporatedInventors: Brian Reed, Jeremy Lackey, Thomas Christian, Roger Nani, David Dodd, Kathren Croce, Alexander Goryaynov, Jonathan M. Rothberg
-
Publication number: 20200209253Abstract: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.Type: ApplicationFiled: December 10, 2019Publication date: July 2, 2020Applicant: Quantum-Si IncorporatedInventors: Brian Reed, Jeremy Lackey, Thomas Christian, Roger Nani, David Dodd, Kathren Croce, Alexander Goryaynov, Jonathan M. Rothberg
-
Publication number: 20200209249Abstract: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.Type: ApplicationFiled: December 10, 2019Publication date: July 2, 2020Applicant: Quantum-Si IncorporatedInventors: Brian Reed, Jeremy Lackey, Thomas Christian, Roger Nani, David Dodd, Kathren Croce, Alexander Goryaynov, Jonathan M. Rothberg
-
Publication number: 20200209254Abstract: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.Type: ApplicationFiled: December 10, 2019Publication date: July 2, 2020Applicant: Quantum-Si IncorporatedInventors: Brian Reed, Jeremy Lackey, Thomas Christian, Roger Nani, David Dodd, Kathren Croce, Alexander Goryaynov, Jonathan M. Rothberg
-
Publication number: 20200209256Abstract: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.Type: ApplicationFiled: December 10, 2019Publication date: July 2, 2020Applicant: Quantum-Si IncorporatedInventors: Brian Reed, Jeremy Lackey, Thomas Christian, Roger Nani, David Dodd, Kathren Croce, Alexander Goryaynov, Jonathan M. Rothberg
-
Publication number: 20200209257Abstract: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.Type: ApplicationFiled: December 10, 2019Publication date: July 2, 2020Applicant: Quantum-Si IncorporatedInventors: Brian Reed, Jeremy Lackey, Thomas Christian, Roger Nani, David Dodd, Kathren Croce, Alexander Goryaynov, Jonathan M. Rothberg
-
Publication number: 20200209255Abstract: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.Type: ApplicationFiled: December 10, 2019Publication date: July 2, 2020Applicant: Quantum-Si IncorporatedInventors: Brian Reed, Jeremy Lackey, Thomas Christian, Roger Nani, David Dodd, Kathren Croce, Alexander Goryaynov, Jonathan M. Rothberg
-
Publication number: 20180223353Abstract: Methods of loading a molecule of interest into a sample well are provided. In some aspects, methods of loading a molecule of interest into a sample well involve loading a molecule of interest into a sample well in the presence of a crowding agent and/or a condensing agent. In some aspects, methods of loading a sequencing template into a sample well are provided.Type: ApplicationFiled: December 19, 2017Publication date: August 9, 2018Applicant: Quantum-Si IncorporatedInventors: James A. Ball, Jeremy Lackey, Brian Reed, Alexander Goryaynov, Jonathan M. Rothberg