Patents by Inventor Alexander Green

Alexander Green has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12116623
    Abstract: Methods for detecting the presence of a pathogen infection are described. In particular, this document provides a method of detecting target nucleic acids, such as pathogen-specific RNA, in a biological sample obtained from a subject, where the method comprises using one or more toehold switch sensors and an isothermal amplification step to detect the target nucleic acid. Methods specific for detecting and identify the presence of a virus such as Zika virus are also provided.
    Type: Grant
    Filed: June 24, 2022
    Date of Patent: October 15, 2024
    Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY, PRESIDENT AND FELLOWS OF HARVARD COLLEGE, MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Alexander Green, Dana Braff, Melissa Takahashi, Keith Pardee, James J. Collins, Guillaume Lambert, Thomas Ferrante
  • Patent number: 12037322
    Abstract: The present invention relates to certain substituted AHR agonist compounds, to pharmaceutical compositions comprising the compounds and to methods of using the compounds to treat immune-mediated diseases.
    Type: Grant
    Filed: September 13, 2022
    Date of Patent: July 16, 2024
    Assignee: ELI LILLY AND COMPANY
    Inventors: Cheryl Ann Carson, Christian Alexander Clarke, Douglas Linn Gernert, Steven James Green, William Glen Holloway, David Gene Barrett
  • Patent number: 12040058
    Abstract: A graphical user interface for displaying an electronic medical record associated with a patient is provided. The graphical user interface may include an area configured to display patient information, which may include at least a name of the patient. The graphical user interface may also include an indicator displayed in association with the name of the patient. The indicator may include information specifying that the patient is potentially eligible for one or more trials, the patient is participating in one or more trials, or the patient has completed one or more trials.
    Type: Grant
    Filed: January 17, 2020
    Date of Patent: July 16, 2024
    Assignee: Flatiron Health, Inc.
    Inventors: Addison Shelley, Achin Batra, Alexander Padmos, Angel Leung, Dominic Green, Frank Zexi Chen, Harvey James Hamrick, Jr., Janet Donegan, Jessie Tseng, Lauren Sutton, Nathan Chan, Rahul Bafna, David Light
  • Publication number: 20240200069
    Abstract: Provided herein are synthetic nucleic acid molecules and methods of using such synthetic nucleic acid molecules for strong repression of target gene expression. In particular, provided herein are methods for altering expression of a protein in a cell, where the method comprises introducing into a cell a protein coding sequence operably linked to a near-threshold translational repressor having first and second trigger recognition sequences that are fully or partially complementary to a repressing trigger RNA; and introducing into a cell the repressing trigger RNA.
    Type: Application
    Filed: January 3, 2024
    Publication date: June 20, 2024
    Inventors: Alexander Green, Yu Zhou
  • Publication number: 20240167678
    Abstract: A burner configured to produce a flame in a combustion zone is provided where the burner includes a combustion air conduit that provides combustion air to the combustion zone, a targeted gas conduit surrounded by the combustion air conduit, the targeted gas provides a targeted gas, such as a NOx reducing medium, to the combustion zone and a fuel gas conduit surrounded by the targeted gas conduit, the fuel gas conduit provides fuel gas to the combustion zone, wherein a portion of the fuel gas is mixed with a portion of the targeted gas prior to mixing with the combustion air in the combustion zone.
    Type: Application
    Filed: September 27, 2023
    Publication date: May 23, 2024
    Inventors: Dusty Ray Richmond, Kurt E. Kraus, Zhili Qin, James W. Harris, Velmurugan Venkatachalam, Alexander Green
  • Patent number: 11952637
    Abstract: Provided herein are methods and compositions for rapid, highly sensitive detection of SARS-CoV-2 in biological samples. In particular, provided herein is a rapid, low-cost method for detecting SARS-CoV-2 that provides reliable, visible test results and does not require PCR reagents, elaborate biosafety precautions, or sophisticated laboratory equipment.
    Type: Grant
    Filed: June 11, 2021
    Date of Patent: April 9, 2024
    Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY, THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
    Inventors: Alexander Green, Keith Pardee, Margot Karlikow, Kaiyue Wu, Masoud Norouzi
  • Publication number: 20240094229
    Abstract: Provided herein are highly modular and sensitive biosensors for small molecule detection using CRISPR/C as enzymes having collateral single-stranded nucleic acid cleavage activity. Also provided herein are uses of the biosensors in detection platforms for convenient, low-cost assessment of safety and purity of consumable samples, environmental samples, and agricultural products.
    Type: Application
    Filed: September 8, 2023
    Publication date: March 21, 2024
    Inventors: Alexander Green, Soma Chaudhary, Kirstie Swingle
  • Publication number: 20240052400
    Abstract: Methods and compositions for detecting the presence of a pathogen are described. In particular, this document provides a method of detecting a pathogen-associated nucleic acid in a biological sample of a subject, where the method comprises using one or more unimolecular aptamer-based sensors comprising an aptamer-fluorophore complex and an amplification step to detect the pathogen-associated nucleic acid. Methods specific for detecting the presence of malaria and other mosquito-borne virus infections are also provided.
    Type: Application
    Filed: August 21, 2023
    Publication date: February 15, 2024
    Inventors: Alexander Green, Duo Ma, Anli Tang
  • Patent number: 11898144
    Abstract: Provided herein are synthetic nucleic acid molecules and methods of using such synthetic nucleic acid molecules for strong repression of target gene expression. In particular, provided herein are methods for altering expression of a protein in a cell, where the method comprises introducing into a cell a protein coding sequence operably linked to a near-threshold translational repressor having first and second trigger recognition sequences that are fully or partially complementary to a repressing trigger RNA; and introducing into a cell the repressing trigger RNA.
    Type: Grant
    Filed: January 22, 2021
    Date of Patent: February 13, 2024
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Alexander Green, Yu Zhou
  • Publication number: 20240043853
    Abstract: Provided herein are highly sensitive compositions and methods for detection of at least one specific nucleic acid molecule in a sample. The presence of a specific nucleic acid provides a positive indicator of a pathogenic agent, contaminant, non-canonical bases, and/or wild-type or mutated genes in a sample or a cell. Applications for which the compositions and methods are particularly well suited include point-of-care disease diagnosis or cellular RNA imaging.
    Type: Application
    Filed: May 3, 2023
    Publication date: February 8, 2024
    Inventors: Alexander Green, Fan Hong
  • Publication number: 20240018608
    Abstract: Provided herein are synthetic nucleic acid molecules known as loop-mediated riboregulators that have single-nucleotide polymorphism (SNP) sensitivity and ultralow OFF state signal levels. Loop-mediated riboregulators can activate or repress gene expression in response to trigger RNAs bearing completely arbitrary sequences. Also provided herein are methods of using such synthetic nucleic acid molecules for detecting the presence or absence of a particular target RNA in, for example, a biological sample.
    Type: Application
    Filed: September 11, 2023
    Publication date: January 18, 2024
    Inventors: Alexander Green, Duo Ma
  • Patent number: 11851339
    Abstract: The present invention is directed to a method of preparing a synthetic crystalline material, designated as JMZ-12, with a framework built up by the disorder AEI and CHA structures, substantially free of framework phosphorous and prepared preferably in the absence of halides such as fluoride ions. Such method comprises the step of heating a reaction mixture under crystallization conditions for a sufficient period to form a disordered zeolite having both CHA and AEI topologies, wherein the reaction mixture comprises at least one source of aluminum, at least one source of silicon, a source of alkaline or alkaline-earth cations, and a structure directing agent containing at least one source of quaternary ammonium cations and at least one source of alkyl-substituted piperidinium cations in a molar ratio of 0.20 to about 1.4. The resulting zeolites are useful as catalysts, particularly when used in combination with exchanged transition metal(s) and, optionally, rare earth metal(s).
    Type: Grant
    Filed: February 28, 2022
    Date of Patent: December 26, 2023
    Inventors: Kaneshalingam Arulraj, Guy R. Chandler, Jillian Collier, Raquel Garcia, Alexander Green, Nicholas Mcnamara, Paul Phillips, Maria Pia Ruggeri, Alessandro Turrina
  • Publication number: 20230366040
    Abstract: Provided herein are methods and compositions for rapid, highly sensitive detection of a target nucleic acid in a sample, which may be indicative of the presence of a pathogen, disease condition, or disease predisposition. In particular, provided herein is a low-cost, portable method for detecting target nucleic acid sequences that rapidly provides reliable, visible test results and does not require elaborate biosafety precautions or sophisticated laboratory equipment.
    Type: Application
    Filed: August 26, 2021
    Publication date: November 16, 2023
    Inventors: Alexander GREEN, Kaiyue WU
  • Publication number: 20230347326
    Abstract: A method of treating exhaust gas from a lean burn internal combustion engine is disclosed. The method comprises: introducing ammonia or an ammonia precursor into the exhaust gas upstream of an Fe-SCR catalyst, the Fe-SCR catalyst comprising iron and a zeolite; and contacting the exhaust gas with the Fe-SCR catalyst; wherein the amount of ammonia or ammonia precursor introduced into the exhaust gas upstream of the Fe-SCR catalyst is controlled to provide an ammonia-to-NOx molar ratio (ANR) in the exhaust gas contacting the Fe-SCR catalyst of from greater than 2 to 6.
    Type: Application
    Filed: April 17, 2023
    Publication date: November 2, 2023
    Inventors: Daniel AVIS, Rafal BARAN, Gavin BROWN, Alexander GREEN, Neil GREENHAM, Matthew HARRIS, Oliver HEMMING, Carmelo IACONO, Caitlin JENKINS, Alanna MURPHY, Paul PHILLIPS
  • Patent number: 11802318
    Abstract: Provided herein are synthetic nucleic acid molecules known as loop-mediated riboregulators that have single-nucleotide polymorphism (SNP) sensitivity and ultralow OFF state signal levels. Loop-mediated riboregulators can activate or repress gene expression in response to trigger RNAs bearing completely arbitrary sequences. Also provided herein are methods of using such synthetic nucleic acid molecules for detecting the presence or absence of a particular target RNA in, for example, a biological sample.
    Type: Grant
    Filed: August 4, 2017
    Date of Patent: October 31, 2023
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Alexander Green, Duo Ma
  • Patent number: 11788156
    Abstract: The invention provides novel and versatile classes of riboregulators, including inter alia activating and repressing riboregulators, switches, and trigger and sink RNA, and methods of their use for detecting RNAs in a sample such as a well and in modulating protein synthesis and expression.
    Type: Grant
    Filed: September 16, 2021
    Date of Patent: October 17, 2023
    Assignees: President and Fellows of Harvard College, Trustees of Boston University
    Inventors: Alexander A. Green, Peng Yin, James J. Collins, Jongmin Kim
  • Patent number: 11788125
    Abstract: Provided herein are imaging probes and systems and methods employing such imaging probes for real-time, label-free, multiplexed imaging of RNAs in living cells. More particularly, aptamer-based sensors (“aptasensors”) and molecular fuses comprising multiple aptasensors are genetically encoded imaging probes comprising RNA-target binding sequence and an intramolecular reconfiguration sequence. The probe is configured such that binding of a RNA target by the RNA-target binding sequence triggers the intramolecular reconfiguration sequence to reconfigure such that an optically detectable output is generated by the probe.
    Type: Grant
    Filed: May 19, 2021
    Date of Patent: October 17, 2023
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventor: Alexander Green
  • Publication number: 20230323487
    Abstract: Provided herein are methods and compositions for rapid, highly sensitive detection of SARS-CoV-2, the causative agent of the COVID-19 pandemic or other target nucleic acids. The methods are low-cost and can be implemented in a portable format that does not require elaborate biosafety precautions or sophisticated laboratory equipment.
    Type: Application
    Filed: August 26, 2021
    Publication date: October 12, 2023
    Inventors: Alexander GREEN, Zhaoqing YAN, Anli TANG
  • Publication number: 20230313283
    Abstract: The technology described herein is directed to methods, kits, and compositions for detecting a target nucleic acid, such as a viral RNA.
    Type: Application
    Filed: February 28, 2023
    Publication date: October 5, 2023
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Alexander GREEN, Zhaoqing YAN, James ROBSON, Padric Michael GARDEN, Milad Babaei AMAMEH
  • Patent number: 11773430
    Abstract: Methods and compositions for detecting the presence of a pathogen are described. In particular, this document provides a method of detecting a pathogen-associated nucleic acid in a biological sample of a subject, where the method comprises using one or more unimolecular aptamer-based sensors comprising an aptamer-fluorophore complex and an amplification step to detect the pathogen-associated nucleic acid. Methods specific for detecting the presence of malaria and other mosquito-borne virus infections are also provided.
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: October 3, 2023
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Alexander Green, Duo Ma, Anli Tang