Abstract: A gut bioreactor includes a fold region and a flow region. The fold regions include members that cooperate to form crypts. The members may have protuberances extending from a surface of the members into the crypts. The gut bioreactors may include multimaterial fibers that are configured to detect aspects of the crypts or may mechanically move portions of the gut bioreactor.

Abstract: In some examples, a microstructured fiber comprises a cladding material surrounding at least one core material, wherein the at least one core material comprises an array of discrete devices contacted in parallel. A method of producing a microstructured fiber may include 3D-printing a fiber preform, thermally drawing the fiber preform into a fiber that preserves the cross-sectional geometry of the fiber preform, and axially patterning the fiber into a microstructured fiber comprising an array of discrete devices contacted in parallel. In some embodiments, microstructured fibers may be integrated into a sensory textile that includes at least one of an electrooptic portion, a sonar portion, a magnetic gradiometer portion, and a piezogenerating portion. In some embodiments, microstructured fibers may be formed into an in-fiber integrated quantum device circuit or an in-fiber ion trap.

Abstract: A platform for testing cell response to biochemical agents. The TrophoWell™ includes a well which contains a gel, and a plurality of capillaries that open into it. Cells and various biochemical agents such as drugs and growth factors are flown through those capillaries. The platform allows for the evaluation of cell response by imaging. The platform is a cost effective testing platform and can be used in the fields for drug discovery and personalized medicine.

Abstract: Technologies for fibers with nanotechnology is disclosed. In the illustrative embodiment, a preform is 3D printed with one or more sacrificial cores and one or more hollow channels. The preform is drawn into a fiber, and one or more metal core(s) is inserted into the hollow channel during the fiber draw. The fiber is then heated, breaking up the sacrificial cores into balls through capillary action. The fiber can be etched, exposing the balls made up of the sacrificial cores. The balls can be selectively etched, exposing the metal core(s) of the fiber. Additional embodiments are disclosed.

Abstract: In some examples, a microstructured fiber comprises a cladding material surrounding at least one core material, wherein the at least one core material comprises an array of discrete devices contacted in parallel. A method of producing a microstructured fiber may include 3D-printing a fiber preform, thermally drawing the fiber preform into a fiber that preserves the cross-sectional geometry of the fiber preform, and axially patterning the fiber into a microstructured fiber comprising an array of discrete devices contacted in parallel. In some embodiments, microstructured fibers may be integrated into a sensory textile that includes at least one of an electrooptic portion, a sonar portion, a magnetic gradiometer portion, and a piezogenerating portion. In some embodiments, microstructured fibers may be formed into an in-fiber integrated quantum device circuit or an in-fiber ion trap.

Abstract: A gut bioreactor includes a fold region and a flow region. The fold regions include members that cooperate to form crypts. The members may have protuberances extending from a surface of the members into the crypts. The gut bioreactors may include multimaterial fibers that are configured to detect aspects of the crypts or may mechanically move portions of the gut bioreactor.

Abstract: A method of producing bioengineered tissue includes coating a microstructured fiber with a bioink containing a plurality of living cells. The microstructured fiber is embedded with microfluidic channels defining periodic outlet apertures, a plurality of ultrasonic transducers, at least one chemical sensor, and at least one temperature sensor. The method further includes applying the coated fiber to an anatomic model of an organ. The microfluidic channels and outlet apertures of the fiber are configured to function as an artificial blood-vessel system to the bioengineered tissue, thereby supplying building material for the proliferation of the plurality of living cells, and allowing the bioengineered tissue to mature into functional tissue.

Abstract: A platform for testing cell response to biochemical agents. The TrophoWell™ includes a well which contains a gel, and a plurality of capillaries that open into it. Cells and various biochemical agents such as drugs and growth factors are flown through those capillaries. The platform allows for the evaluation of cell response by imaging. The platform is a cost effective testing platform and can be used in the fields for drug discovery and personalized medicine.

Abstract: A fiber is provided that has been thermally drawn from a fiber preform, having a longitudinal-axis length and including at least one core that has a longitudinal core axis parallel to the longitudinal axis and internally disposed to at least one outer fiber cladding material layer along the fiber length. The fiber is fed through a localized heating site having a heating site temperature, T, that is above a melting temperature of the fiber core, with a feed speed, ?f, that melts a portion of the fiber core at the heating site, causing molten droplets to pinch off of fiber core material, one droplet at a time, with a time period of molten droplet formation set by the fiber feed speed, ?f. The fiber is fed through the localized heating site to move the molten droplets out of the heating site and solidify the molten droplets into solid in-fiber particles.

Abstract: There is provided a sensor fiber including an electrically insulating material having a fiber length. At least one transduction element is disposed along at least a portion of the fiber length and is arranged for exposure to an intake species. A photoconducting element is in optical communication with the transduction element. At least one pair of electrically conducting electrodes are in electrical connection with the photoconducting element. The pair of electrodes extend the fiber length.

Abstract: According to some aspects, an additive fabrication device for forming solid objects within a build region is provided, the device comprising a laser source, an aspheric lens configured to receive light emitted by the laser source and to produce a light beam having a circular cross section at at least one position inside the build region, and at least one mirror configured to be actuated to reflect the light beam toward a selected position within the build region.

Abstract: Herein is provided a fiber that includes a cladding material disposed along a longitudinal-axis fiber length and a plurality of discrete and disconnected high-stress domains that are disposed as a sequence along a longitudinal line parallel to the longitudinal fiber axis in at least a portion of the fiber length. Each high stress domain has an internal pressure of at least 0.1 GPa and comprises a material that is interior to and different than the fiber cladding material.

Abstract: According to some aspects, an additive fabrication device for forming solid objects within a build region is provided, the device comprising a laser source, an aspheric lens configured to receive light emitted by the laser source and to produce a light beam having a circular cross section at at least one position inside the build region, and at least one mirror configured to be actuated to reflect the light beam toward a selected position within the build region.

Abstract: A fiber is provided that has been thermally drawn from a fiber preform, having a longitudinal-axis length and including at least one core that has a longitudinal core axis parallel to the longitudinal axis and internally disposed to at least one outer fiber cladding material layer along the fiber length. The fiber is fed through a localized heating site having a heating site temperature, T, that is above a melting temperature of the fiber core, with a feed speed, ?f, that melts a portion of the fiber core at the heating site, causing molten droplets to pinch off of fiber core material, one droplet at a time, with a time period of molten droplet formation set by the fiber feed speed, ?f. The fiber is fed through the localized heating site to move the molten droplets out of the heating site and solidify the molten droplets into solid in-fiber particles.

Abstract: Herein is provided a fiber that includes a cladding material disposed along a longitudinal-axis fiber length and a plurality of discrete and disconnected high-stress domains that are disposed as a sequence along a longitudinal line parallel to the longitudinal fiber axis in at least a portion of the fiber length. Each high stress domain has an internal pressure of at least 0.1 GPa and comprises a material that is interior to and different than the fiber cladding material.

Abstract: There is provided a sensor fiber including an electrically insulating material having a fiber length. At least one transduction element is disposed along at least a portion of the fiber length and is arranged for exposure to an intake species. A photoconducting element is in optical communication with the transduction element. At least one pair of electrically conducting electrodes are in electrical connection with the photoconducting element. The pair of electrodes extend the fiber length.