Abstract: The present invention relates to the novel use of certain piperidinyl-indole derivatives in the treatment of patients suffering from renal diseases or disorders, and in particular for the treatment of patients suffering from C3G (C3 glomerulopathy) and IgAN (IgA nephropathy).

Abstract: The present invention relates to the novel use of certain piperidinyl-indole derivatives in the treatment of patients suffering from renal diseases or disorders, and in particular for the treatment of patients suffering from C3G (C3 glomerulopathy) and IgAN (IgA nephropathy).

Abstract: A method includes obtaining position information relating to an object in a sporting event, determining, based on the position information, that a start event has occurred, wherein the start event indicates a start of play of the sporting event, and generating, according to a result of the determination, an instruction to start storing position information relating to the object.

Abstract: A method that simulates a response of a target person to one or more simulation inputs comprises: contacting a body of a first test subject with a force-sensing probe; measuring a first force applied by the probe to the body of the first test subject; obtaining a first relative movement comprising a first movement of the probe relative to the body of the first test subject; determining one or more model parameters associated with the body of the first test subject based on the measured first force and the first relative movement; incorporating the one or more model parameters into a target model of at least a portion of a body of a target person; obtaining a simulation input for application to the target model; and simulating a response of the target person in response to the simulation input using the target model.

Abstract: Described is a method of manufacturing carboxymethyl cellulose (CMC) fibres containing an antimicrobial, the fibres being suitable for use in the preparation of wound dressings, wherein the antimicrobial is selected from the group consisting of a biguanide, a biguanide derivative, octenidine, taurolidine, and a combination of two or more thereof, the method comprising, submerging CMC fibres comprising at least 95 wt % carboxymethylcellulose on a dry weight basis in a treatment solution for a duration adequate to provide the CMC fibres containing an antimicrobial, the treatment solution comprising the antimicrobial and at least 70 wt % of a water-miscible organic solvent selected from C1-C4 alkanols, C3-C5 ketones, and a combination of two or more thereof. Anti-microbial CMC fibres obtained by the methods and wound dressings containing such fibres are also described.

Abstract: The present invention relates to the novel use of certain piperidinyl-indole derivatives in the treatment of patients suffering from renal diseases or disorders, and in particular for the treatment of patients suffering from C3G (C3 glomerulopathy) and IgAN (IgA nephropathy).

Abstract: Described is a composition that includes: (i) a drug against tuberculosis inhibiting the cytochrome b subunit of the bc1 complex, said cytochrome b subunit being encoded by the gene qcrB, in Mycobacterium tuberculosis, or a pharmaceutically acceptable salt thereof, and (ii) a compound of Formula II, or a pharmaceutically acceptable salt thereof.

Abstract: A method that simulates a response of a target person to one or more simulation inputs comprises: contacting a body of a first test subject with a force-sensing probe; measuring a first force applied by the probe to the body of the first test subject; obtaining a first relative movement comprising a first movement of the probe relative to the body of the first test subject; determining one or more model parameters associated with the body of the first test subject based on the measured first force and the first relative movement; incorporating the one or more model parameters into a target model of at least a portion of a body of a target person; obtaining a simulation input for application to the target model; and simulating a response of the target person in response to the simulation input using the target model.

Abstract: The invention provides compositions comprising Eno1 and a muscle targeting peptide, e.g, as a fusion protein, for delivery of Eno1 to a muscle. The Eno1 may contain one or more added cysteine residues which are covalently attached to a biocompatible polymer (e.g. polyethylene glycol). Further, the invention provides a method for normalizing blood glucose in a subject with elevated blood glucose, comprising administering to the subject enolase 1 (Eno1), thereby normalizing blood glucose in the subject. The invention also provides methods of treating one or more conditions including impaired glucose tolerance, insulin resistance, pre-diabetes, and diabetes, especially type 2 diabetes in a subject, comprising administering to the subject enolase 1 (Eno1), thereby treating the condition in the subject.

Abstract: An enclosure for storage, transport, and display of pins for trading includes: a front and a back connected together by a first closure mechanism, such as a zipper; and a second closure mechanism such as a zipper located on an exterior of and connecting a clear cover to the front. The enclosure defines an enclosed interior space between the front and the back in which mounting surfaces are located for pins. The cover and an outwardly facing surface of the front define another enclosed interior space having an additional mounting surface for the mounting pins to be seen through the clear cover and showcased.

Abstract: A book enclosure for the storage, transport and display of decorative pins. The book has page (s) that open for the viewing, securing, protecting and safe transportation of decorative pins in which the page surface is comprised of a puncturable and resilient material for the piercing through and repositioning of the post (s) portion of a decorative pin(s) and defining a mounting surface for decorative pins. Between the page (s) there is a protective page to prevent decorative pins from contact and potential damage. A translucent front with a zipper allows for the display and viewing of decorative pins. A zipper closure allows for the secure closure to protect pins from falling out. The book has a removable strap for shoulder or cross-body portage or to hang for display. The back of the book has a pouch enclosure for the storage of pin backs.

Abstract: The present invention relates to the novel use of certain piperidinyl-indole derivatives in the treatment of patients suffering from renal diseases or disorders, and in particular for the treatment of patients suffering from C3G (C3 glomerulopathy) and IgAN (IgA nephropathy).

Abstract: Described is a composition that includes: (i) a drug against tuberculosis inhibiting the cytochrome b subunit of the bc1 complex, said cytochrome b subunit being encoded by the gene qcrB, in Mycobacterium tuberculosis, or a pharmaceutically acceptable salt thereof, and (ii) a compound of Formula II or a pharmaceutically acceptable salt thereof.

Abstract: A book enclosure for the storage, transport and display of decorative pins. The book has page (s) that open for the viewing, securing, protecting and safe transportation of decorative pins in which the page surface is comprised of a puncturable and resilient material for the piercing through and repositioning of the post (s) portion of a decorative pin(s) and defining a mounting surface for decorative pins. Between the page (s) there is a protective page to prevent decorative pins from contact and potential damage. A translucent front with a zipper allows for the display and viewing of decorative pins. A zipper closure allows for the secure closure to protect pins from falling out. The book has a removable strap for shoulder or cross-body portage or to hang for display. The back of the book has a pouch enclosure for the storage of pin backs.

Abstract: A book enclosure for the storage, transport and display of decorative pins. The book has page (s) that open for the viewing, securing, protecting and safe transportation of decorative pins in which the page surface is comprised of a puncturable and resilient material for the piercing through and repositioning of the post (s) portion of a decorative pin(s) and defining a mounting surface for decorative pins. Between the page (s) there is a protective page to prevent decorative pins from contact and potential damage. A translucent front with a zipper allows for the display and viewing of decorative pins. A zipper closure allows for the secure closure to protect pins from falling out. The book has a removable strap for shoulder or cross-body portage or to hang for display. The back of the book has a pouch enclosure for the storage of pin backs.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for providing a gestural interface in vehicle. In one aspect, movement data corresponding to a gesture of a driver of a vehicle is received from a radar receiver arranged to detect movement at the interior of the vehicle. The gesture is determined to be a particular gesture from among a first predetermined set of gestures for selecting an operating mode of a computing device. In response, a computing device is caused to enter an operating mode corresponding to the particular mode selection gesture, and a determination is made whether a subsequent movement of the driver represents a gesture from a second predetermined set of gestures that is different from the first predetermined set of gestures.

Abstract: The invention relates to antibodies which treat diseases in which human IL-8, Gro-alpha, Gro-beta, Gro-gamma, GCP-2, and/or ENA-78 are implicated.